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We propose a new experimentally corroborated paradigm in which the functionality of the brain's logic-gates depends on the history of their activity, e.g. an OR-gate that turns into a XOR-gate over time. Our results are based on an…

Neurons and Cognition · Quantitative Biology 2015-06-15 Roni Vardi , Shoshana Guberman , Amir Goldental , Ido Kanter

Classical autoassociative memory models have been central to understanding emergent computations in recurrent neural circuits across diverse biological contexts. However, they typically neglect neuromodulatory agents that are known to…

Neurons and Cognition · Quantitative Biology 2025-12-17 Daiki Goto , Hector Manuel Lopez Rios , Monika Scholz , Suriyanarayanan Vaikuntanathan

Metaheuristic and self-organizing criticality (SOC) could contribute to robust computation under perturbed environments. Implementing a logic gate in a computing system in a critical state is one of the intriguing ways to study the role of…

Artificial Intelligence · Computer Science 2021-12-16 Yukio-Pegio Gunji , Yoshihiko Ohzawa , Terutaka Tanaka

Neuroprosthesis, as one type of precision medicine device, is aiming for manipulating neuronal signals of the brain in a closed-loop fashion, together with receiving stimulus from the environment and controlling some part of our brain/body.…

Neurons and Cognition · Quantitative Biology 2020-01-14 Zhaofei Yu , Jian K. Liu , Shanshan Jia , Yichen Zhang , Yajing Zheng , Yonghong Tian , Tiejun Huang

We advocate here the use of computational logic for systems biology, as a \emph{unified and safe} framework well suited for both modeling the dynamic behaviour of biological systems, expressing properties of them, and verifying these…

Quantitative Methods · Quantitative Biology 2020-10-07 Elisabetta de Maria , Joelle Despeyroux , Amy Felty , Pietro Liò , Carlos Olarte , Abdorrahim Bahrami

The Integrated Information is a quantitative measure from information theory how tightly all parts of a system are interconnected in terms of information exchange. In this study we show that astrocyte, playing an important role in…

Neurons and Cognition · Quantitative Biology 2019-01-30 Oleg Kanakov , Susanna Gordleeva , Anastasia Ermolaeva , Sarika Jalan , Alexey Zaikin

Despite remarkable capabilities, artificial neural networks exhibit limited flexible, generalizable intelligence. This limitation stems from their fundamental divergence from biological cognition that overlooks both neural regions'…

Artificial Intelligence · Computer Science 2025-11-05 Boheng Liu , Ziyu Li , Qing Li , Xia Wu

Neuromorphic computing has emerged as a promising avenue towards building the next generation of intelligent computing systems. It has been proposed that memristive devices, which exhibit history-dependent conductivity modulation, could…

In the rapidly advancing field of neuromorphic computing, integrating biologically-inspired models like the Leaky Integrate-and-Fire Astrocyte (LIFA) into spiking neural networks (SNNs) enhances system robustness and performance. This paper…

Neural and Evolutionary Computing · Computer Science 2025-03-03 Aybars Yunusoglu , Dexter Le , Murat Isik , I. Can Dikmen , Teoman Karadag

Recent years have witnessed an increasing interest in neuron-glia communication. This interest stems from the realization that glia participates in cognitive functions and information processing and is involved in many brain disorders and…

Neurons and Cognition · Quantitative Biology 2009-12-17 Maurizio De Pitta` , Mati Goldberg , Vladislav Volman , Hugues Berry , Eshel Ben-Jacob

Mounting evidence in recent years suggests that astrocytes, a sub-type of glial cells, not only serve metabolic and structural support for neurons and synapses but also play critical roles in regulation of proper functioning of the nervous…

Neurons and Cognition · Quantitative Biology 2022-05-18 Tugba Palabas , Andre Longtin , Dibakar Ghosh , Muhammet Uzuntarla

While spike timing has been shown to carry detailed stimulus information at the sensory periphery, its possible role in network computation is less clear. Most models of computation by neural networks are based on population firing rates.…

Neurons and Cognition · Quantitative Biology 2015-07-17 Michael A. Schwemmer , Adrienne L. Fairhall , Sophie Denéve , Eric T. Shea-Brown

During the last years, a well studied biological substrate, namely Physarum polycephalum, has been proven efficient on finding appropriate and efficient solutions in hard to solve complex mathematical problems. The plasmodium of P.…

Spikes are the currency in central nervous systems for information transmission and processing. They are also believed to play an essential role in low-power consumption of the biological systems, whose efficiency attracts increasing…

Neural and Evolutionary Computing · Computer Science 2020-05-05 Qiang Yu , Shenglan Li , Huajin Tang , Longbiao Wang , Jianwu Dang , Kay Chen Tan

We report an experimental evaluation of the "input-output surface" for a biochemical AND gate. The obtained data are modeled within the rate-equation approach, with the aim to map out the gate function and cast it in the language of logic…

Molecular Networks · Quantitative Biology 2010-10-12 V. Privman , G. Strack , D. Solenov , M. Pita , E. Katz

Brain functions require both segregated processing of information in specialized circuits, as well as integration across circuits to perform high-level information processing. One possible way to implement these seemingly opposing demands…

We present an approach for constructing dynamic models for the simulation of gene regulatory networks from simple computational elements. Each element is called a ``gene gate'' and defines an input/output-relationship corresponding to the…

Molecular Networks · Quantitative Biology 2007-10-09 R. Blossey , L. Cardelli , A. Phillips

Understanding how the dynamics of neural networks is shaped by the computations they perform is a fundamental question in neuroscience. Recently, the framework of efficient coding proposed a theory of how spiking neural networks can compute…

Neurons and Cognition · Quantitative Biology 2022-10-25 Veronika Koren , Stefano Panzeri

Exploiting the effects of quantum interference we put forward an idea of designing three primary logic gates, OR, AND and NOT, using a benzene molecule. Under a specific molecule-lead interface geometry, anti-resonant states appear which…

Mesoscale and Nanoscale Physics · Physics 2018-09-19 Moumita Patra , Santanu K. Maiti

One of the most interesting and still growing scientific fields is neuromorphic engineering, which is focused on studying and designing hardware and software with the purpose of mimicking the basic principles of biological nervous systems.…

Neural and Evolutionary Computing · Computer Science 2022-10-06 Alvaro Ayuso-Martinez , Daniel Casanueva-Morato , Juan P. Dominguez-Morales , Angel Jimenez-Fernandez , Gabriel Jimenez-Moreno