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Neuronal growth cones are the most sensitive amongst eukaryotic cells in responding to directional chemical cues. Although a dynamic microtubule cytoskeleton has been shown to be essential for growth cone turning, the precise nature of…

Subcellular Processes · Quantitative Biology 2019-05-16 Saurabh Mahajan , Chaitanya A. Athale

Actin growth is a fundamental biophysical process and it is, at the same time, a prototypical example of diffusion-mediated surface growth. We formulate a coupled chemo-mechanical, one-dimensional growth model encompassing both material…

Soft Condensed Matter · Physics 2020-01-03 Rohan Abeyaratne , Eric Puntel , Giuseppe Tomassetti

Microtubules (MTs) are dynamic protein filaments essential for intracellular organization and transport, particularly in long-lived cells such as neurons. The plus and minus ends of neuronal MTs switch between growth and shrinking phases,…

Biological Physics · Physics 2025-07-11 Anna C. Nelson , Scott A. McKinley , Melissa M. Rolls , Maria-Veronica Ciocanel

We develop a backstepping control design for a class of continuum systems of linear hyperbolic PDEs, described by a coupled system of an ensemble of rightward transporting PDEs and a (finite) system of $m$ leftward transporting PDEs. The…

Optimization and Control · Mathematics 2024-10-30 Jukka-Pekka Humaloja , Nikolaos Bekiaris-Liberis

We extend a recently proposed model (Chaudhuri et al., EPL 87, 20003 (2009)) aiming to describe the formation of fascicles of axons during neural development. The growing axons are represented as paths of interacting directed random walkers…

Biological Physics · Physics 2015-03-13 Debasish Chaudhuri , Peter Borowski , Martin Zapotocky

Transient spine enlargement (3-5 min timescale) is an important event associated with the structural plasticity of dendritic spines. Many of the molecular mechanisms associated with transient spine enlargement have been identified…

Subcellular Processes · Quantitative Biology 2023-07-19 Padmini Rangamani , Michael G. Levy , Shahid M. Khan , George Oster

Local anaxonic neurons with graded potential release are important ingredients of nervous systems, present in the olfactory bulb system of mammalians, in the human visual system, as well as in arthropods and nematodes. We develop a neuronal…

Neurons and Cognition · Quantitative Biology 2021-04-14 M. Rahimi-Majd , M. A. Seifi , L. de Arcangelis , M. N. Najafi

It is well known that for ordinary one-dimensional (1D) disordered systems, the Anderson localization length $\xi$ diverges as $\lambda^m$ in the long wavelength limit ($\lambda\rightarrow \infty$ ) with a universal exponent $m=2$,…

Disordered Systems and Neural Networks · Physics 2019-04-22 A. Fang , Z. Q. Zhang , Steven G. Louie , C. T. Chan

This paper addresses boundary prescribed-time stabilization of a one-dimensional heat equation with spatially and temporally varying coefficients. In contrast to asymptotic or exponential stabilization, prescribed-time stabilization ensures…

Optimization and Control · Mathematics 2026-02-27 Kaijing Lyu , Umberto Biccari , Jun-Min Wang

Neural networks have been applied to control problems, typically by combining data, differential equation residuals, and objective costs in the training loss or by incorporating auxiliary architectural components. Instead, we propose a…

Optimization and Control · Mathematics 2026-04-10 Oliver G. S. Lundqvist , Fabricio Oliveira

Spiking Neural Networks are powerful computational modelling tools that have attracted much interest because of the bioinspired modelling of synaptic interactions between neurons. Most of the research employing spiking neurons has been…

Neural and Evolutionary Computing · Computer Science 2019-03-05 Huanneng Qiu , Matthew Garratt , David Howard , Sreenatha Anavatti

We present designs for exponential stabilization of an ODE-heat PDE-ODE coupled system where the control actuation only acts in one ODE. The combination of PDE backstepping and ODE backstepping is employed in a state-feedback control law…

Optimization and Control · Mathematics 2019-03-26 Ji Wang , Miroslav Krstic

This paper develops a control and estimation design for the one-phase Stefan problem. The Stefan problem represents a liquid-solid phase transition as time evolution of a temperature profile in a liquid-solid material and its moving…

Optimization and Control · Mathematics 2017-03-20 Shumon Koga , Mamadou Diagne , Miroslav Krstic

We consider a free boundary problem for a system of PDEs, modeling the growth of a biological tissue. A morphogen, controlling volume growth, is produced by specific cells and then diffused and absorbed throughout the domain. The geometric…

Analysis of PDEs · Mathematics 2017-11-22 Alberto Bressan , Marta Lewicka

This paper presents a safe stabilization of the Stefan PDE model with a moving boundary governed by a high-order dynamics. We consider a parabolic PDE with a time-varying domain governed by a second-order response with respect to the…

Optimization and Control · Mathematics 2025-10-09 Shumon Koga , Miroslav Krstic

This paper investigates the mean square exponential stabilization problem for a class of coupled PDE-ODE systems with Markov jump parameters. The considered system consists of multiple coupled hyperbolic PDEs and a finite-dimensional ODE,…

Optimization and Control · Mathematics 2025-08-06 Kaijing Lyu , Umberto Biccari , Junmin Wang

This paper deals with the exponential stability of systems made of a hyperbolic PDE coupled with an ODE with different time scales, the dynamics of the PDE being much faster than that of the ODE. Such a difference of time scales is modeled…

Analysis of PDEs · Mathematics 2024-03-12 Gonzalo Arias , Swann Marx , Guilherme Mazanti

This paper discusses the stability of an equilibrium point of an ordinary differential equation (ODE) arising from a feed-forward position control for a musculoskeletal system. The studied system has a link, a joint and two muscles with…

Dynamical Systems · Mathematics 2019-04-30 Takahiro Kosugi , Hitoshi Kino , Masaaki Goto , Yuki Matsutani

In this paper we propose two nonlinear models for the control of anthracnose disease. The first is an ordinary differential equation (ODE) model which represents the within-host evolution of the disease. The second includes spatial…

Optimization and Control · Mathematics 2014-06-17 David Fotsa , Elvis Houpa , David Békollé , Christopher Thron , Michel Ndoumbé

We consider the problem of output feedback regulationfor a linear first-order hyperbolic system with collocatedinput and output in presence of a general class of disturbancesand noise. The proposed control law is designed through…

Analysis of PDEs · Mathematics 2017-10-20 Pierre-Olivier Lamare , Jean Auriol , Florent Di Meglio , Ulf Jakob F. Aarsnes
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