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Parkinson disease is a very common neurodegenerative disorder. Patients usually undergo destruction of substantia nigra to develop typical symptoms such as resting tremor, hypokinesia, and rigidity. However, the exact mechanism of Parkinson…

Other Quantitative Biology · Quantitative Biology 2014-03-14 Wan-Chung Hu

Parkinson's Disease (PD) is a chronic and progressive neurological disorder that results in rigidity, tremors and postural instability. There is no definite medical test to diagnose PD and diagnosis is mostly a clinical exercise. Although…

Image and Video Processing · Electrical Eng. & Systems 2021-07-28 Shanmukh Alle , U. Deva Priyakumar

Parkinson's disease (PD) is projected to increase substantially due to population aging, making early diagnosis increasingly important, as timely detection may delay progression and reduce long-term complications. Retinal microvasculature…

In recent years, sensors from smart consumer devices have shown great diagnostic potential in movement disorders. In this context, data modalities such as electronic questionnaires, hand movement and voice captures have successfully…

Machine Learning · Computer Science 2022-05-13 Catharina Marie van Alen , Alexander Brenner , Tobias Warnecke , Julian Varghese

Background: Parkinson's disease (PD) is a prevalent long-term neurodegenerative disease. Though the diagnostic criteria of PD are relatively well defined, the current medical imaging diagnostic procedures are expertise-demanding, and thus…

Quantitative Methods · Quantitative Biology 2019-02-27 Jiahang Xu , Fangyang Jiao , Yechong Huang , Xinzhe Luo , Qian Xu , Ling Li , Xueling Liu , Chuantao Zuo , Ping Wu , Xiahai Zhuang

Parkinson's disease (PD) affects over ten million people worldwide. Although temporal interference (TI) and deep brain stimulation (DBS) are promising therapies, inter-individual variability limits empirical treatment selection, increasing…

Neurons and Cognition · Quantitative Biology 2026-04-01 Siyuan Du , Siyi Li , Shuwei Bai , Ang Li , Haolin Li , Mingqing Xiao , Yang Pan , Dongsheng Li , Weidi Xie , Yanfeng Wang , Ya Zhang , Chencheng Zhang , Jiangchao Yao

Bradykinesia, characterized by involuntary slowing or decrement of movement, is a fundamental symptom of Parkinson's Disease (PD) and is vital for its clinical diagnosis. Despite various methodologies explored to quantify bradykinesia,…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Youngseo Cho , In Hee Kwak , Dohyeon Kim , Jinhee Na , Hanjoo Sung , Jeongjae Lee , Young Eun Kim , Hyeo-il Ma

Freezing-of-gait a mysterious symptom of Parkinsons disease and defined as a sudden loss of ability to move forward. Common treatments of freezing episodes are currently of moderate efficacy and can likely be improved through a reliable…

Signal Processing · Electrical Eng. & Systems 2020-09-29 Ying Wang , Floris Beuving , Jorik Nonnekes , Mike X Cohen , Xi Long , Ronald M Aarts , Richard Van Wezel

Parkinson's disease (PD) is a non-curable disease that commonly found among elders that greatly reduce their quality of life. PD primarily affects the gait pattern and slowly changes the walking gait from the normality to disability. The…

Machine Learning · Computer Science 2021-02-02 Musthaq Ahamed , P. D. S. H. Gunawardane , Nimali T. Medagedara

Parkinson's disease is a neurodegenerative disorder characterized by the presence of different motor impairments. Information from speech, handwriting, and gait signals have been considered to evaluate the neurological state of the…

Audio and Speech Processing · Electrical Eng. & Systems 2020-06-14 J. C. Vasquez-Correa , T. Bocklet , J. R. Orozco-Arroyave , E. Nöth

Parkinson's Disease PD is a progressive neurodegenerative disorder that affects motor and cognitive functions with early diagnosis being critical for effective clinical intervention Electroencephalography EEG offers a noninvasive and…

Eye movements can reveal early signs of neurodegeneration, including those associated with Parkinson's Disease (PD). This work investigates the utility of a set of gaze-based features for the automatic screening of PD from different visual…

Neurons and Cognition · Quantitative Biology 2025-09-03 Maria F. Alcala-Durand , J. Camilo Puerta-Acevedo , Julián D. Arias-Londoño , Juan I. Godino-Llorente

Parkinson's Disease (PD) medication management presents unique challenges due to heterogeneous disease progression and treatment response. Neurologists must balance symptom control with optimal dopaminergic dosing based on functional…

Machine Learning · Computer Science 2025-08-15 Ricardo Diaz-Rincon , Muxuan Liang , Adolfo Ramirez-Zamora , Benjamin Shickel

Identification of risk factors associated with falls in people with Parkinson's Disease (PD) is important due to their high risk of falling. In this study, various ways of utilizing the Unified Parkinson's Disease Rating Scale (UPDRS) were…

Applications · Statistics 2019-10-04 Sarini Abdullah , Nicole White , James McGree , Kerrie Mengersen , Graham Kerr

Parkinson's disease (PD) is a neurological disorder requiring early and accurate diagnosis for effective management. Machine learning (ML) has emerged as a powerful tool to enhance PD classification and diagnostic accuracy, particularly by…

Parkinsons disease (PD) is considered one of the most frequent neurological diseases in the world. There is a need to study the early and efficient biomarkers of Parkinsons, such as changes in structural disorders like DNA and chromatin,…

Recent works in pathological speech analysis have increasingly relied on powerful self-supervised speech representations, leading to promising results. However, the complex, black-box nature of these embeddings and the limited research on…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 David Gimeno-Gómez , Catarina Botelho , Anna Pompili , Alberto Abad , Carlos-D. Martínez-Hinarejos

Music has been shown to enhance motor control in patients with Parkinson's disease (PD). Notably, musical rhythm is perceived as an external auditory cue that helps PD patients to better control movements. The rationale of such effects is…

Neurons and Cognition · Quantitative Biology 2018-12-19 Lauriane Véron-Delor , Serge Pinto , Alexandre Eusebio , Jean-Luc Velay , Jérémy Danna

Background and objectives: Dynamic handwriting analysis, due to its non-invasive and readily accessible nature, has recently emerged as a vital adjunctive method for the early diagnosis of Parkinson's disease. In this study, we design a…

Artificial Intelligence · Computer Science 2023-11-21 Xuechao Wang , Junqing Huang , Sven Nomm , Marianna Chatzakou , Kadri Medijainen , Aaro Toomela , Michael Ruzhansky

Detecting Parkinson's Disease in its early stages using EEG data presents a significant challenge. This paper introduces a novel approach, representing EEG data as a 15-variate series of bandpower and peak frequency values/coefficients. The…

Neurons and Cognition · Quantitative Biology 2023-12-11 Amarpal Sahota , Amber Roguski , Matthew W. Jones , Michal Rolinski , Alan Whone , Raul Santos-Rodriguez , Zahraa S. Abdallah