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A transversal study of the pitch variability of parkinsonian voices in read speech is presented. 30 patients suffering from Parkinson's disease (PD) and 32 healthy speakers were recorded while reading a text without voiceless phonemes. The…

Audio and Speech Processing · Electrical Eng. & Systems 2024-02-12 Pablo Rodriguez-Perez , Ruben Fraile , Miguel Garcia-Escrig , Nicolas Saenz-Lechon , Juana M. Gutierrez-Arriola , Victor Osma-Ruiz

Early detection of Parkinson's disease (PD) is important which can enable early initiation of therapeutic interventions and management strategies. However, methods for early detection still remain an unmet clinical need in PD. In this…

Applications · Statistics 2018-10-04 R Prashanth , Sumantra Dutta Roy

This paper reviews related work and state-of-the-art publications for recognizing motor symptoms of Parkinson's Disease (PD). It presents research efforts that were undertaken to inform on how well traditional machine learning algorithms…

Artificial Intelligence · Computer Science 2013-12-16 Claas Ahlrichs , Michael Lawo

Up to 90 % of patients with Parkinson's disease (PD) suffer from hypokinetic dysarthria (HD). In this work, we analysed the power of conventional speech features quantifying imprecise articulation, dysprosody, speech dysfluency and speech…

Parkinson's disease (PD) is a neurodegenerative disorder characterized by increased response times leading to a variety of biomechanical symptoms such as tremors, stooping and gait instability. Although the deterioration in biomechanical…

Quantitative Methods · Quantitative Biology 2017-07-27 Vrutangkumar Shah , Sachin Goyal , Harish Palanthandalam-Madapusi

Speech impairments in Parkinson's disease (PD) provide significant early indicators for diagnosis. While models for speech-based PD detection have shown strong performance, their interpretability remains underexplored. This study…

Sound · Computer Science 2024-11-14 Eleonora Mancini , Francesco Paissan , Paolo Torroni , Mirco Ravanelli , Cem Subakan

Parkinson's disease (PD) is a common neurodegenerative disorder that severely diminishes patients' quality of life. Its global prevalence has increased markedly in recent decades. Current diagnostic workflows are complex and heavily reliant…

Computer Vision and Pattern Recognition · Computer Science 2026-03-12 Shuai Shao , Yan Wang , Shu Jiang , Shiyuan Zhao , Di Yang , Jiangtao Wang , Yutong Bai , Jianguo Zhang

In this study, we explored the use of spectrograms to represent handwriting signals for assessing neurodegenerative diseases, including 42 healthy controls (CTL), 35 subjects with Parkinson's Disease (PD), 21 with Alzheimer's Disease (AD),…

Machine Learning · Computer Science 2025-02-12 Sarah Laouedj , Yuzhe Wang , Jesus Villalba , Thomas Thebaud , Laureano Moro-Velazquez , Najim Dehak

Objective: We present the PaHaW Parkinson's disease handwriting database, consisting of handwriting samples from Parkinson's disease (PD) patients and healthy controls. Our goal is to show that kinematic features and pressure features in…

Computer Vision and Pattern Recognition · Computer Science 2024-11-06 Peter Drotár , Jiří Mekyska , Irena Rektorová , Lucia Masarová , Zdeněk Smékal , Marcos Faundez-Zanuy

The stage and severity of Parkinson's disease (PD) is an important factor to consider for taking effective therapeutic decisions. Although the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) provides an…

Applications · Statistics 2018-05-30 R. Prashanth , Sumantra Dutta Roy

Parkinson's disease (PD) is a debilitating neurological disorder that necessitates precise and early diagnosis for effective patient care. This study aims to develop a diagnostic model capable of achieving both high accuracy and minimizing…

Machine Learning · Computer Science 2024-01-30 Seyedeh Zahra Seyedi Hosseininian , Ahmadreza Tajari , Mohsen Ghalehnoie , Alireza Alfi

The rapid emergence of highly adaptable and reusable artificial intelligence (AI) models is set to revolutionize the medical field, particularly in the diagnosis and management of Parkinson's disease (PD). Currently, there are no effective…

Machine Learning · Computer Science 2025-02-18 Aite Zhao , Yongcan Liu , Xinglin Yu , Xinyue Xing

We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants…

Parkinson's Disease (PD) is a progressive neurodegenerative movement disorder that affects more that 6 million people worldwide. Motor dysfunction gradually increases as the disease progress. It is usually mild in the early stages of the…

Computers and Society · Computer Science 2015-11-12 Ioannis Pachoulakis , Nikolaos Papadopoulos , Cleanthe Spanaki

Parkinson's disease (PD) severity diagnosis is crucial for early detecting potential patients and adopting tailored interventions. Diagnosing PD based on facial expression is grounded in PD patients' "masked face" symptom and gains growing…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Yintao Zhou , Wei Huang , Zhengyu Li , Jing Huang , Meng Pang

Limited accessibility to neurological care leads to underdiagnosed Parkinson's Disease (PD), preventing early intervention. Existing AI-based PD detection methods primarily focus on unimodal analysis of motor or speech tasks, overlooking…

Computer Vision and Pattern Recognition · Computer Science 2025-04-29 Md Saiful Islam , Tariq Adnan , Jan Freyberg , Sangwu Lee , Abdelrahman Abdelkader , Meghan Pawlik , Cathe Schwartz , Karen Jaffe , Ruth B. Schneider , E Ray Dorsey , Ehsan Hoque

Parkinsons disease (PD) diagnosis is challenging due to subtle early clinical signs. F-DOPA PET is commonly used for early PD diagnosis. We explore the potential of machine-learning (ML) based EEG features extracted from single-channel EEG…

Neurons and Cognition · Quantitative Biology 2023-08-08 Lior Molcho , Neta B. Maimon , Neomi Hezi , Talya Zeimer , Nathan Intrator , Tanya Gurevich

Parkinson's disease (PD) is a neurodegenerative disorder, manifesting with motor and non-motor symptoms. Depressive symptoms are prevalent in PD, affecting up to 45% of patients. They are often underdiagnosed due to overlapping motor…

Parkinson's disease (PD), a severe and progressive neurological illness, affects millions of individuals worldwide. For effective treatment and management of PD, an accurate and early diagnosis is crucial. This study presents a deep…

Signal Processing · Electrical Eng. & Systems 2023-08-16 Niloufar Delfan , Mohammadreza Shahsavari , Sadiq Hussain , Robertas Damaševičius , U. Rajendra Acharya

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder where motor dysfunction gradually increases as the disease progress. In addition to administering dopaminergic PD-specific drugs, attending neurologists strongly…

Computers and Society · Computer Science 2015-11-10 Ioannis Pachoulakis , Nikolaos Papadopoulos , Cleanthe Spanaki
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