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Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique in biomedical research that uses the fluorophore decay rate to provide additional contrast in fluorescence microscopy. However, at present, the calculation, analysis,…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Varun Mannam , Yide Zhang , Xiaotong Yuan , Cara Ravasio , Scott S. Howard

Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Paloma Casteleiro Costa , Parnian Ghapandar Kashani , Xuhui Liu , Alexander Chen , Ary Portes , Julien Bec , Laura Marcu , Aydogan Ozcan

A critical factor in adopting machine learning for time-sensitive financial tasks is computational speed, including model training and inference. This paper demonstrates that a broad class of such problems, especially those previously…

Computational Finance · Quantitative Finance 2025-05-27 Liexin Cheng , Xue Cheng , Shuaiqiang Liu

The Extreme Learning Machine (ELM) technique is a machine learning approach for constructing feed-forward neural networks with a single hidden layer and their models. The ELM model can be constructed while being trained by concurrently…

Optimization and Control · Mathematics 2024-01-30 Muideen Adegoke , Lateef O. Jolaoso , Mardiyyah Oduwole

We introduce a rapid and precise analytical approach for analyzing cerebral blood flow (CBF) using Diffuse Correlation Spectroscopy (DCS) with the application of the Extreme Learning Machine (ELM). Our evaluation of ELM and existing…

Machine Learning · Computer Science 2024-02-02 Xi Chen , Zhenya Zang , Xingda Li

Extreme Learning Machines (ELM) provide a fast alternative to traditional gradient-based learning in neural networks, offering rapid training and robust generalization capabilities. Its theoretical basis shows its universal approximation…

Machine Learning · Computer Science 2024-06-27 Ergun Biçici

Fluorescence lifetime imaging microscopy (FLIM) systems are limited by their slow processing speed, low signal-to-noise ratio (SNR), and expensive and challenging hardware setups. In this work, we demonstrate applying a denoising…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Varun Mannam , Yide Zhang , Xiaotong Yuan , Takashi Hato , Pierre C. Dagher , Evan L. Nichols , Cody J. Smith , Kenneth W. Dunn , Scott Howard

The optical domain is a promising field for physical implementation of neural networks, due to the speed and parallelism of optics. Extreme Learning Machines (ELMs) are feed-forward neural networks in which only output weights are trained,…

Emerging Technologies · Computer Science 2021-09-01 Alessandro Lupo , Lorenz Butschek , Serge Massar

Increasing resolution and coverage of astrophysical and climate data necessitates increasingly sophisticated models, often pushing the limits of computational feasibility. While emulation methods can reduce calculation costs, the neural…

Earth and Planetary Astrophysics · Physics 2025-06-25 Tara P. A. Tahseen , Luís F. Simões , Kai Hou Yip , Nikolaos Nikolaou , João M. Mendonça , Ingo P. Waldmann

Photonic neural networks offer a promising alternative to traditional electronic systems for machine learning accelerators due to their low latency and energy efficiency. However, the challenge of implementing the backpropagation algorithm…

Machine learning technologies have found fertile ground in optics due to its promising features based on speed and parallelism. Feed-forward neural networks are one of the most widely used machine learning algorithms due to their simplicity…

Emerging Technologies · Computer Science 2023-10-25 Stefano Biasi , Riccardo Franchi , Lorenzo Cerini , Lorenzo Pavesi

Extreme learning machine (ELM) as a neural network algorithm has shown its good performance, such as fast speed, simple structure etc, but also, weak robustness is an unavoidable defect in original ELM for blended data. We present a new…

Machine Learning · Computer Science 2014-09-24 Bo Han , Bo He , Rui Nian , Mengmeng Ma , Shujing Zhang , Minghui Li , Amaury Lendasse

Extreme learning machine (ELM) is an extremely fast learning method and has a powerful performance for pattern recognition tasks proven by enormous researches and engineers. However, its good generalization ability is built on large numbers…

Machine Learning · Computer Science 2015-02-05 Wentao Zhu , Jun Miao , Laiyun Qing

Extreme learning machine (ELM), proposed by Huang et al., has been shown a promising learning algorithm for single-hidden layer feedforward neural networks (SLFNs). Nevertheless, because of the random choice of input weights and biases, the…

Neural and Evolutionary Computing · Computer Science 2014-09-16 Yuguang Wang , Feilong Cao , Yubo Yuan

We demonstrate an electro-optic wide-field method to enable fluorescence lifetime microscopy (FLIM) with high throughput and single-molecule sensitivity. Resonantly driven Pockels cells are used to efficiently gate images at 39 MHz,…

Optics · Physics 2021-09-23 Adam J. Bowman , Mark A. Kasevich

We report the development and detailed calibration of a multiphoton fluorescence lifetime imaging system (FLIM) using a streak camera. The present system is versatile with high spatial (0.2 micron) and temporal (50 psec) resolution and…

Quantitative Methods · Quantitative Biology 2009-11-10 R. V. Krishnan , H. Saitoh , H. Terada , V. E. Centonze , B. Herman

The Extreme Learning Machine (ELM) is a growing statistical technique widely applied to regression problems. In essence, ELMs are single-layer neural networks where the hidden layer weights are randomly sampled from a specific distribution,…

Machine Learning · Statistics 2025-07-31 Daniela De Canditiis , Fabiano Veglianti

This paper reported a bespoke adder-based deep learning network for time-domain fluorescence lifetime imaging (FLIM). By leveraging the l1-norm extraction method, we propose a 1-D Fluorescence Lifetime AdderNet (FLAN) without…

Signal Processing · Electrical Eng. & Systems 2022-09-13 Zhenya Zang , Dong Xiao , Quan Wang , Ziao Jiao , Chen Yu , David Day-Uei Li

Extreme Learning Machine (ELM) is an efficient and effective least-square-based learning algorithm for classification, regression problems based on single hidden layer feed-forward neural network (SLFN). It has been shown in the literature…

Machine Learning · Computer Science 2020-11-05 Ramesh Ragala , Bharadwaja kumar

The inverse-free extreme learning machine (ELM) algorithm proposed in [4] was based on an inverse-free algorithm to compute the regularized pseudo-inverse, which was deduced from an inverse-free recursive algorithm to update the inverse of…

Machine Learning · Computer Science 2019-11-13 Hufei Zhu , Chenghao Wei
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