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Many cortical areas increase in size considerably during postnatal development, progressively displacing neuronal cell bodies from each other. At present, little is known about how cortical growth affects the development of neuronal…

Neurons and Cognition · Quantitative Biology 2011-04-12 Wolfgang Keil , Karl-Friedrich Schmidt , Siegrid Loewel , Matthias Kaschube

Traditional neural networks, while powerful, rely on biologically implausible learning mechanisms such as global backpropagation. This paper introduces the Structurally Adaptive Predictive Inference Network (SAPIN), a novel computational…

Neural and Evolutionary Computing · Computer Science 2026-02-11 Brennen A. Hill

It is widely accepted that the hippocampal place cells' spiking activity produces a cognitive map of space. However, many details of this representation's physiological mechanism remain unknown. For example, it is believed that the place…

Neurons and Cognition · Quantitative Biology 2015-09-08 A. Babichev , D. Ji , F. Memoli , Y. Dabaghian

The entorhinal-hippocampal circuit plays a critical role in higher brain functions, especially spatial cognition. Grid cells in the medial entorhinal cortex (MEC) periodically fire with different grid spacing and orientation, which makes a…

Neurons and Cognition · Quantitative Biology 2019-10-11 Taiping Zeng , XiaoLi Li , Bailu Si

Most types of retinal neurons are spatially positioned in non-random patterns, termed retinal mosaics. Several developmental mechanisms are thought to be important in the formation of these mosaics. Most evidence to date suggests that…

Neurons and Cognition · Quantitative Biology 2012-08-07 Stephen J. Eglen , James C. T. Wong

A hallmark of human intelligence is the ability to adapt to new situations, by applying learned rules to new content (systematicity) and thereby enabling an open-ended number of inferences and actions (generativity). Here, we propose that…

Neurons and Cognition · Quantitative Biology 2021-08-10 Randall C. O'Reilly , Charan Ranganath , Jacob L. Russin

The spatial structure of the cell is highly organized at all levels: from small complexes and assemblies, to local nano- and micro-clusters, to global, micrometer scales across and between cells. We suggest that this multiscale spatial cell…

Biomolecules · Quantitative Biology 2013-08-06 Ruth Nussinov

The occurrence of a critical period of plasticity in the visual cortex has long been established, yet its function in normal development is not fully understood. Here we show that as the late phase of the critical period unfolds, different…

Neurons and Cognition · Quantitative Biology 2015-05-13 Matthias Kaschube , Michael Schnabel , Siegrid Löwel , Fred Wolf

Cognitive maps play a crucial role in facilitating flexible behaviour by representing spatial and conceptual relationships within an environment. The ability to learn and infer the underlying structure of the environment is crucial for…

Artificial Intelligence · Computer Science 2023-09-20 Daria de Tinguy , Toon Van de Maele , Tim Verbelen , Bart Dhoedt

In the mammalian brain, many neuronal ensembles are involved in representing spatial structure of the environment. In particular, there exist cells that encode the animal's location and cells that encode head direction. A number of studies…

Neurons and Cognition · Quantitative Biology 2021-08-10 Y. Dabaghian

Although normal homologous brain structures are approximately symmetrical by definition, they also have shape differences due to e.g. natural ageing. On the other hand, neurodegenerative conditions induce their own changes in this…

Neurons and Cognition · Quantitative Biology 2023-06-29 Duilio Deangeli , Emmanuel Iarussi , Juan Pablo Princich , Mariana Bendersky , Ignacio Larrabide , José Ignacio Orlando

The brain has a great capacity for computation and efficient resolution of complex problems, far surpassing modern computers. Neuromorphic engineering seeks to mimic the basic principles of the brain to develop systems capable of achieving…

Spatial systems with heterogeneities are ubiquitous in nature, from precipitation, temperature and soil gradients controlling vegetation growth to morphogen gradients controlling gene expression in embryos. Such systems, generally described…

Dynamical Systems · Mathematics 2023-05-10 Denis D. Patterson , Simon A. Levin , A. Carla Staver , Jonathan D. Touboul

Cognitive maps provide a powerful framework for understanding spatial and abstract reasoning in biological and artificial agents. While recent computational models link cognitive maps to hippocampal-entorhinal mechanisms, they often rely on…

Neurons and Cognition · Quantitative Biology 2025-10-07 E. A. Dzhivelikian , A. I. Panov

We develop of a line of work initiated by Curto and Itskov towards understanding the amount of information contained in the spike trains of hippocampal place cells via topology considerations. Previously, it was established that simply…

Neurons and Cognition · Quantitative Biology 2018-11-21 Samir Chowdhury , Bowen Dai , Facundo Mémoli

Protocol-dependent states in structural glasses can encode a disordered, yet retrievable memory. While training such materials is typically done via a global drive, such as external shear, in dense active matter the driving is instead local…

Soft Condensed Matter · Physics 2024-04-05 Elisabeth Agoritsas , Peter K. Morse

Place cells in the hippocampus are active when an animal visits a certain location (referred to as a place field) within an environment. Grid cells in the medial entorhinal cortex (MEC) respond at multiple locations, with firing fields that…

Neurons and Cognition · Quantitative Biology 2018-05-17 David M. Schwartz , O. Ozan Koyluoglu

We study the synchronisation of neurons in a realistic model under the Hodgkin-Huxley dynamics. To focus on the role of the different locations of the excitatory synapses, we use two identical neurons where the set of input signals is…

Neurons and Cognition · Quantitative Biology 2024-09-17 Alessandro Fiasconaro , Michele Migliore

A central problem to understanding intelligence is the concept of generalisation. This allows previously learnt structure to be exploited to solve tasks in novel situations differing in their particularities. We take inspiration from…

Artificial Intelligence · Computer Science 2018-10-30 James C. R. Whittington , Timothy H. Muller , Shirley Mark , Caswell Barry , Timothy E. J. Behrens

Image synthesis and image-to-image translation are two important generative learning tasks. Remarkable progress has been made by learning Generative Adversarial Networks (GANs)~\cite{goodfellow2014generative} and cycle-consistent GANs…

Computer Vision and Pattern Recognition · Computer Science 2019-01-21 Wei Sun , Tianfu Wu