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The grid cells (GCs) of the medial entorhinal cortex (MEC) and place cells (PCs) of the hippocampus are key elements of the brain network for the metric representation of space. Currently, any of the existing theoretical models can explain…
The proposed analysis of the currently available experimental results concerning the neural cell activity in the brain area known as hippocampus suggests a particular mechanism of spatial information and memory processing. Below it is…
Neural computation is associated with the emergence, reconfiguration and dissolution of cell assemblies in the context of varying oscillatory states. Here, we describe the complex spatio-temporal dynamics of cell assemblies through temporal…
Learning and interpreting the structure of the environment is an innate feature of biological systems, and is integral to guiding flexible behaviours for evolutionary viability. The concept of a cognitive map has emerged as one of the…
During sleep, the hippocampus recapitulates neuronal patterns corresponding to behavioral trajectories during previous experiences. This hippocampal replay supports the formation of long-term memories. Yet, whether replay originates within…
The acoustic cues used by humans and other animals to localise sounds are subtle, and change during and after development. This means that we need to constantly relearn or recalibrate the auditory spatial map throughout our lifetimes. This…
Hippocampal cognitive map---a neuronal representation of the spatial environment---is broadly discussed in the computational neuroscience literature for decades. More recent studies point out that hippocampus plays a major role in producing…
The hippocampus is an essential brain region for spatial memory and learning. Recently, a theoretical model of the hippocampus based on temporal difference (TD) learning has been published. Inspired by the successor representation (SR)…
The hippocampus is often attributed to episodic memory formation and storage in the mammalian brain; in particular, Alme et al. showed that hippocampal area CA3 forms statistically independent representations across a large number of…
Learning and memory relies on synapses changing their strengths in response to neural activity. However there is a substantial gap between the timescales of neural electrical dynamics (1-100 ms) and organism behaviour during learning…
Alzheimer's disease (AD) is a complex neurodegenerative condition that manifests at multiple levels and involves a spectrum of abnormalities ranging from the cellular to cognitive. Here, we investigate the impact of AD-related tau-pathology…
New cells are generated throughout life and integrate into the hippocampus via the process of adult neurogenesis. Epileptogenic brain injury induces many structural changes in the hippocampus, including the death of interneurons and altered…
Sequential firing of hippocampal place cells is often attributed to sequential sensory drive along a trajectory, and has also been attributed to planning and other cognitive functions. Here, we propose a mechanistic and parsimonious…
The human brain possesses the extraordinary capability to contextualize the information it receives from our environment. The entorhinal-hippocampal plays a critical role in this function, as it is deeply engaged in memory processing and…
Biological neural networks exist in physical space where distance influences communication delays: a fundamental coupling between space and time absent in most artificial neural networks. While recent work has separately explored spatial…
In the mammalian brain, newly acquired memories depend on the hippocampus for maintenance and recall, but over time the neocortex takes over these functions, rendering memories hippocampus-independent. The process responsible for this…
Synchronization in neural system plays an important role in many brain functions. Synchronization in the gamma frequency band (30Hz-100Hz) is involved in a variety of cognitive phenomena; abnormalities of the gamma synchronization are found…
Topological data analyses are rapidly turning into key tools for quantifying large volumes of neurobiological data, e.g., for organizing the spiking outputs of large neuronal ensembles and thus gaining insights into the information produced…
The hippocampus has been associated with both spatial cognition and episodic memory formation, but integrating these functions into a unified framework remains challenging. Here, we demonstrate that forming discrete memories of visual…
A coupled map is suggested to investigate various spatial or temporal designs in biology: Several cells (or tissues) in an organ are considered as connected to each other in terms of some molecular diffusions or electrical potential…