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Question answering is a natural language understanding task that involves reasoning over both explicit context, and unstated relevant domain knowledge. Despite the high cost of training, large language models (LLMs) -- the backbone of most…

Computation and Language · Computer Science 2025-04-24 Laura Cabello , Carmen Martin-Turrero , Uchenna Akujuobi , Anders Søgaard , Carlos Bobed

Recent advancements in Large Language Models (LLMs) have demonstrated significant promise in clinical diagnosis. However, current models struggle to emulate the iterative, diagnostic hypothesis-driven reasoning of real clinical scenarios.…

Computation and Language · Computer Science 2026-01-06 Qipeng Wang , Rui Sheng , Yafei Li , Huamin Qu , Yushi Sun , Min Zhu

Biomedical knowledge is fragmented across siloed databases -- Reactome for pathways, STRING for protein interactions, ClinicalTrials.gov for study registries, DrugBank for drug vocabularies, DGIdb for drug-gene interactions, SIDER for side…

Databases · Computer Science 2026-03-19 Madhulatha Mandarapu , Sandeep Kunkunuru

Ontologies and knowledge graphs (KGs) are general-purpose computable representations of some domain, such as human anatomy, and are frequently a crucial part of modern information systems. Most of these structures change over time,…

This comprehensive review aims to provide an overview of the current state of Healthcare Knowledge Graphs (HKGs), including their construction, utilization models, and applications across various healthcare and biomedical research domains.…

LLMs are bound to transform healthcare with advanced decision support and flexible chat assistants. However, LLMs are prone to generate inaccurate medical content. To ground LLMs in high-quality medical knowledge, LLMs have been equipped…

Computation and Language · Computer Science 2025-06-10 Qinyue Zheng , Salman Abdullah , Sam Rawal , Cyril Zakka , Sophie Ostmeier , Maximilian Purk , Eduardo Reis , Eric J. Topol , Jure Leskovec , Michael Moor

Research knowledge graphs (RKGs) have emerged as essential technology for organizing scientific knowledge, but their success depends heavily on the quality of their underlying content. Knowledge curation is a critical task to ensure the…

Digital Libraries · Computer Science 2026-03-03 Lena John , Sören Auer , Oliver Karras

Information extraction and data mining in biochemical literature is a daunting task that demands resource-intensive computation and appropriate means to scale knowledge ingestion. Being able to leverage this immense source of technical…

Biomedical knowledge graphs are increasingly large, dynamic, and multimodal, driven by rapid advances in biotechnology such as high-throughput sequencing. Machine learning models can infer previously unobserved biomedical relationships and…

Machine Learning · Computer Science 2026-05-12 Yousef A. Radwan , Yao Li , Qing Qing , Ziqi Xu , Qixin Zhang , Yongcheng Jing , Renqiang Luo , Xikun Zhang

Standardising the representation of biomedical knowledge among all researchers is an insurmountable task, hindering the effectiveness of many computational methods. To facilitate harmonisation and interoperability despite this fundamental…

Schema matching is a critical task in data integration, particularly in the medical domain where disparate Electronic Health Record (EHR) systems must be aligned to standard models like OMOP CDM. While Large Language Models (LLMs) have…

Artificial Intelligence · Computer Science 2025-12-02 Mingyu Jeon , Jaeyoung Suh , Suwan Cho

The storage and manipulation of digital images and the analysis of the information held in those images are essential requirements for next-generation medical information systems. The medical community has been exploring collaborative…

Databases · Computer Science 2007-05-23 D Rogulin , F Estrella , T Hauer , R McClatchey , T Solomonides

The Artificial Intelligence Ontology (AIO) is a systematization of artificial intelligence (AI) concepts, methodologies, and their interrelations. Developed via manual curation, with the additional assistance of large language models…

Knowledge in materials science is widely dispersed across extensive scientific literature, posing significant challenges to the efficient discovery and integration of new materials. Traditional methods, often reliant on costly and…

Computation and Language · Computer Science 2025-05-16 Yanpeng Ye , Jie Ren , Shaozhou Wang , Yuwei Wan , Imran Razzak , Bram Hoex , Haofen Wang , Tong Xie , Wenjie Zhang

Question Answering (QA) is a natural language processing task that aims at obtaining relevant answers to user questions. While some progress has been made in this area, biomedical questions are still a challenge to most QA approaches, due…

Information Retrieval · Computer Science 2020-12-23 Andre Lamurias , Diana Sousa , Francisco M. Couto

The ability to understand and generate similes is an imperative step to realize human-level AI. However, there is still a considerable gap between machine intelligence and human cognition in similes, since deep models based on statistical…

Computation and Language · Computer Science 2022-12-13 Qianyu He , Xintao Wang , Jiaqing Liang , Yanghua Xiao

Clinicians are increasingly looking towards machine learning to gain insights about patient evolutions. We propose a novel approach named Multi-Modal UMLS Graph Learning (MMUGL) for learning meaningful representations of medical concepts…

Machine Learning · Computer Science 2024-02-07 Manuel Burger , Gunnar Rätsch , Rita Kuznetsova

Knowledge Graphs (KG) constitute a flexible representation of complex relationships between entities particularly useful for biomedical data. These KG, however, are very sparse with many missing edges (facts) and the visualisation of the…

Artificial Intelligence · Computer Science 2016-12-08 Armando Vieira

The continuous growth of scientific literature brings innovations and, at the same time, raises new challenges. One of them is related to the fact that its analysis has become difficult due to the high volume of published papers for which…

Computation and Language · Computer Science 2020-11-06 Danilo Dessì , Francesco Osborne , Diego Reforgiato Recupero , Davide Buscaldi , Enrico Motta