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Estimating dependence relationships between variables is a crucial issue in many applied domains, such as medicine, social sciences and psychology. When several variables are entertained, these can be organized into a network which encodes…

Methodology · Statistics 2025-01-01 Federico Castelletti

Simultaneous recordings from many neurons hide important information and the connections characterizing the network remain generally undiscovered despite the progresses of statistical and machine learning techniques. Discerning the presence…

Applications · Statistics 2019-03-21 Pietro Verzelli , Laura Sacerdote

Gene regulatory networks play a crucial role in controlling an organism's biological processes, which is why there is significant interest in developing computational methods that are able to extract their structure from high-throughput…

Machine Learning · Statistics 2019-09-11 Ioan Gabriel Bucur , Tom Claassen , Tom Heskes

Gene regulatory networks play a crucial role in controlling an organism's biological processes, which is why there is significant interest in developing computational methods that are able to extract their structure from high-throughput…

Machine Learning · Statistics 2018-09-19 Ioan Gabriel Bucur , Tom van Bussel , Tom Claassen , Tom Heskes

Motivation: Algorithms that discover variables which are causally related to a target may inform the design of experiments. With observational gene expression data, many methods discover causal variables by measuring each variable's degree…

Quantitative Methods · Quantitative Biology 2014-07-30 Eric V. Strobl , Shyam Visweswaran

Graphical models or networks describe the statistical dependence among multiple variables and are widely used in biology (e.g., gene regulatory networks). Under appropriate assumptions, directed edges may represent causal relationships. A…

Methodology · Statistics 2023-11-29 Evan A Martin , Audrey Qiuyan Fu

Causal discovery aims to infer causal relationships among variables from observational data, typically represented by a directed acyclic graph (DAG). Most existing methods assume independent and identically distributed observations, an…

Methodology · Statistics 2026-03-27 Alex Chen , Qing Zhou

In recent biomedical scientific problems, it is a fundamental issue to integratively cluster a set of objects from multiple sources of datasets. Such problems are mostly encountered in genomics, where data is collected from various sources,…

Change detection (CD) in heterogeneous remote sensing images has been widely used for disaster monitoring and land-use management. In the past decade, the heterogeneous CD problem has significantly benefited from the development of deep…

Computer Vision and Pattern Recognition · Computer Science 2025-03-17 Weiming Li , Xueqian Wang , Gang Li , Baocheng Geng , Pramod K. Varshney

Regular vine copulas can describe a wider array of dependency patterns than the multivariate Gaussian copula or the multivariate Student's t copula. This paper presents two contributions related to model selection of regular vine copulas.…

Statistics Theory · Mathematics 2015-12-04 Lutz Gruber , Claudia Czado

In this report a systematic approach is used to determine the approximate genetic network and robust dependencies underlying differentiation. The data considered is in the form of a binary matrix and represent the expression of the nine…

Molecular Networks · Quantitative Biology 2007-05-23 Radhakrishnan Nagarajan , Jane E. Aubin , Charlotte A. Peterson

We propose a class of dynamic vine copula models. This is an extension of static vine copulas and a generalization of dynamic C-vine and D-vine copulas studied by Almeida et al (2016) and Goel and Mehra (2019). Within this class, we allow…

Methodology · Statistics 2019-11-05 Alexander Kreuzer , Claudia Czado

Copula-based models provide a great deal of flexibility in modelling multivariate distributions, allowing for the specifications of models for the marginal distributions separately from the dependence structure (copula) that links them to…

Methodology · Statistics 2021-09-09 Nicolás Kuschinski , Alejandro Jara

Discovering causal genetic variants from large genetic association studies poses many difficult challenges. Assessing which genetic markers are involved in determining trait status is a computationally demanding task, especially in the…

Genomics · Quantitative Biology 2015-04-09 Andrew L. Beam , Alison Motsinger-Reif , Jon Doyle

Gaussian graphical models provide a powerful framework to reveal the conditional dependency structure between multivariate variables. The process of uncovering the conditional dependency network is known as structure learning. Bayesian…

Methodology · Statistics 2024-07-30 Lucas Vogels , Reza Mohammadi , Marit Schoonhoven , S. Ilker Birbil

We introduce a copula mixture model to perform dependency-seeking clustering when co-occurring samples from different data sources are available. The model takes advantage of the great flexibility offered by the copulas framework to extend…

Methodology · Statistics 2012-07-03 Melanie Rey , Volker Roth

Gene covariation networks are commonly used to study biological processes. The inference of gene covariation networks from observational data can be challenging, especially considering the large number of players involved and the small…

Molecular Networks · Quantitative Biology 2019-04-17 Anatoly Yambartsev , Michael Perlin , Yevgeniy Kovchegov , Natalia Shulzhenko , Karina L. Mine , Xiaoxi Dong , Andrey Morgun

We show that the two-stage minimum description length (MDL) criterion widely used to estimate linear change-point (CP) models corresponds to the marginal likelihood of a Bayesian model with a specific class of prior distributions. This…

Methodology · Statistics 2023-06-09 David Ardia , Arnaud Dufays , Carlos Ordas Criado

Explaining artificial intelligence or machine learning models is increasingly important. To use such data-driven systems wisely we must understand how they interact with the world, including how they depend causally on data inputs. In this…

Machine Learning · Computer Science 2023-07-06 Joshua R. Loftus , Lucius E. J. Bynum , Sakina Hansen

We consider learning continuous probabilistic graphical models in the face of missing data. For non-Gaussian models, learning the parameters and structure of such models depends on our ability to perform efficient inference, and can be…

Machine Learning · Computer Science 2012-03-19 Gal Elidan
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