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The direct Gaussian copula model with discrete marginal distributions is an appealing data-analytic tool but poses difficult computational challenges due to its intractable likelihood. A number of approximations/surrogates for the…

Methodology · Statistics 2021-03-08 John Hughes

We present a coherent Bayesian framework for selection of the most likely model from the five genetic models (genotypic, additive, dominant, co-dominant, and recessive) commonly used in genetic association studies. The approach uses a…

Methodology · Statistics 2015-04-22 Harold Bae , Thomas Perls , Martin Steinberg , Paola Sebastiani

The dynamic characteristics of multiphase industrial processes present significant challenges in the field of industrial big data modeling. Traditional soft sensing models frequently neglect the process dynamics and have difficulty in…

Machine Learning · Computer Science 2024-07-09 Yimeng He , Le Yao , Xinmin Zhang , Xiangyin Kong , Zhihuan Song

Quantification of microbial interactions from 16S rRNA and meta-genomic sequencing data is difficult due to their sparse nature, as well as the fact that the data only provides measures of relative abundance. In this paper, we propose using…

Methodology · Statistics 2021-11-04 Rebecca A. Deek , Hongzhe Li

Constructing gene regulatory networks is a fundamental task in systems biology. We introduce a Gaussian reciprocal graphical model for inference about gene regulatory relationships by integrating mRNA gene expression and DNA level…

Methodology · Statistics 2016-07-26 Yang Ni , Yuan Ji , Peter Mueller

Motivation: Several different threads of research have been proposed for modeling and mining temporal data. On the one hand, approaches such as dynamic Bayesian networks (DBNs) provide a formal probabilistic basis to model relationships…

Machine Learning · Computer Science 2009-04-15 Debprakash Patnaik , Srivatsan Laxman , Naren Ramakrishnan

This paper presents a Bayesian approach to learning the connectivity structure of a group of neurons from data on configuration frequencies. A major objective of the research is to provide statistical tools for detecting changes in firing…

Machine Learning · Computer Science 2013-02-18 Kathryn Blackmond Laskey , Laura Martignon

Current causal discovery approaches require restrictive model assumptions in the absence of interventional data to ensure structure identifiability. These assumptions often do not hold in real-world applications leading to a loss of…

Machine Learning · Statistics 2025-06-25 Anish Dhir , Ruby Sedgwick , Avinash Kori , Ben Glocker , Mark van der Wilk

Regression analysis is one of the most popularly used statistical technique which only measures the direct effect of independent variables on dependent variable. Path analysis looks for both direct and indirect effects of independent…

Methodology · Statistics 2024-06-26 Alam Ali , Ashok Kumar Pathak , Mohd Arshad , Ayyub Sheikhi

Diffusion probabilistic models (DPMs) have become a popular approach to conditional generation, due to their promising results and support for cross-modal synthesis. A key desideratum in conditional synthesis is to achieve high…

Computer Vision and Pattern Recognition · Computer Science 2023-02-17 Ye Zhu , Yu Wu , Kyle Olszewski , Jian Ren , Sergey Tulyakov , Yan Yan

We present the Deep Copula Classifier (DCC), a class-conditional generative model that separates marginal estimation from dependence modeling using neural copula densities. DCC is interpretable, Bayes-consistent, and achieves excess-risk…

Machine Learning · Statistics 2025-10-28 Agnideep Aich , Ashit Baran Aich

Whereas acausal Bayesian networks represent probabilistic independence, causal Bayesian networks represent causal relationships. In this paper, we examine Bayesian methods for learning both types of networks. Bayesian methods for learning…

Artificial Intelligence · Computer Science 2015-05-19 David Heckerman

In this paper we propose a flexible class of multivariate nonlinear non-Gaussian state space models, based on copulas. More precisely, we assume that the observation equation and the state equation are defined by copula families that are…

Methodology · Statistics 2019-11-04 Alexander Kreuzer , Luciana Dalla Valle , Claudia Czado

Methodological development for the inference of gene regulatory networks from transcriptomic data is an active and important research area. Several approaches have been proposed to infer relationships among genes from observational…

Applications · Statistics 2013-06-28 Grégory Nuel , Andrea Rau , Florence Jaffrézic

Discrete diffusion models have recently shown significant progress in modeling complex data, such as natural languages and DNA sequences. However, unlike diffusion models for continuous data, which can generate high-quality samples in just…

Machine Learning · Computer Science 2025-03-20 Anji Liu , Oliver Broadrick , Mathias Niepert , Guy Van den Broeck

In this article we propose novel Bayesian nonparametric methods using Dirichlet Process Mixture (DPM) models for detecting pairwise dependence between random variables while accounting for uncertainty in the form of the underlying…

Methodology · Statistics 2016-04-28 Sarah Filippi , Chris C. Holmes , Luis E. Nieto-Barajas

Causal discovery methods aim to infer causal direction from observational data. Functional causal discovery approaches use structural asymmetries to identify causal directionality but rely on strong modeling assumptions and provide limited…

Methodology · Statistics 2026-05-14 Shreya Prakash , Fan Xia , Elena A. Erosheva

Learning causal relationships between pairs of complex traits from observational studies is of great interest across various scientific domains. However, most existing methods assume the absence of unmeasured confounding and restrict causal…

Methodology · Statistics 2024-07-17 Wei Li , Rui Duan , Sai Li

Constraint-based causal discovery algorithms utilize many statistical tests for conditional independence to uncover networks of causal dependencies. These approaches to causal discovery rely on an assumed correspondence between the…

Machine Learning · Computer Science 2025-04-18 Bijan Mazaheri , Jiaqi Zhang , Caroline Uhler

Identifying causal relations among multi-variate time series is one of the most important elements towards understanding the complex mechanisms underlying the dynamic system. It provides critical tools for forecasting, simulations and…

Machine Learning · Computer Science 2023-02-22 Yang Sun , Yifan Xie
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