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Related papers: Score-Based Generative Models for Molecule Generat…

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Unsupervised deep learning has recently demonstrated the promise of producing high-quality samples. While it has tremendous potential to promote the image colorization task, the performance is limited owing to the high-dimension of data…

Computer Vision and Pattern Recognition · Computer Science 2022-08-19 Jin Li , Wanyun Li , Zichen Xu , Yuhao Wang , Qiegen Liu

Generative modeling has drawn much attention in creative and scientific data generation tasks. Score-based Diffusion Models, a type of generative model that iteratively learns to denoise data, have shown state-of-the-art results on tasks…

Robotics · Computer Science 2024-05-21 Tyler Presser , Agnimitra Dasgupta , Daniel Erwin , Assad Oberai

Efficiently retrieving an enormous chemical library to design targeted molecules is crucial for accelerating drug discovery, organic chemistry, and optoelectronic materials. Despite the emergence of generative models to produce novel…

Computational Engineering, Finance, and Science · Computer Science 2024-09-13 Zijun Chen , Yu Wang , Liuzhenghao Lv , Hao Li , Zongying Lin , Li Yuan , Yonghong Tian

We present a novel approach to reconstruct gas and dark matter projected density maps of galaxy clusters using score-based generative modeling. Our diffusion model takes in mock SZ and X-ray images as conditional inputs, and generates…

Cosmology and Nongalactic Astrophysics · Physics 2025-07-16 Alan Hsu , Matthew Ho , Joyce Lin , Carleen Markey , Michelle Ntampaka , Hy Trac , Barnabás Póczos

While working within the spatial domain can pose problems associated with ill-conditioned scores caused by power-law decay, recent advances in diffusion-based generative models have shown that transitioning to the wavelet domain offers a…

Artificial Intelligence · Computer Science 2024-11-15 Xiongye Xiao , Shixuan Li , Luzhe Huang , Gengshuo Liu , Trung-Kien Nguyen , Yi Huang , Di Chang , Mykel J. Kochenderfer , Paul Bogdan

Score-based generative models (SGMs) are a powerful class of generative models that exhibit remarkable empirical performance. Score-based generative modelling (SGM) consists of a ``noising'' stage, whereby a diffusion is used to gradually…

Machine Learning · Computer Science 2022-11-23 Valentin De Bortoli , Emile Mathieu , Michael Hutchinson , James Thornton , Yee Whye Teh , Arnaud Doucet

Diffusion models have recently emerged as a powerful framework for generative modeling. They consist of a forward process that perturbs input data with Gaussian white noise and a reverse process that learns a score function to generate…

Deep generative models have recently been applied to molecule design. If the molecules are encoded in linear SMILES strings, modeling becomes convenient. However, models relying on string representations tend to generate invalid samples and…

Machine Learning · Computer Science 2020-10-20 Bo Pang , Tian Han , Ying Nian Wu

Score-based generative models (SGMs) have demonstrated remarkable synthesis quality. SGMs rely on a diffusion process that gradually perturbs the data towards a tractable distribution, while the generative model learns to denoise. The…

Machine Learning · Statistics 2022-03-28 Tim Dockhorn , Arash Vahdat , Karsten Kreis

Most existing generative models are limited to learning a single probability distribution from the training data and cannot generalize to novel distributions for unseen data. An architecture that can generate samples from both trained…

Machine Learning · Computer Science 2024-10-16 Xinyu Liao , Aoyang Qin , Jacob Seidman , Junqi Wang , Wei Wang , Paris Perdikaris

Score-based generative models (SGMs) are generative models that are in the spotlight these days. Time-series frequently occurs in our daily life, e.g., stock data, climate data, and so on. Especially, time-series forecasting and…

Machine Learning · Computer Science 2023-01-23 Haksoo Lim , Minjung Kim , Sewon Park , Noseong Park

Score-based generative models and diffusion probabilistic models have been successful at generating high-quality samples in continuous domains such as images and audio. However, due to their Langevin-inspired sampling mechanisms, their…

Sound · Computer Science 2021-11-29 Gautam Mittal , Jesse Engel , Curtis Hawthorne , Ian Simon

Score-based generative models (SGMs) are a popular family of deep generative models that achieve leading image generation quality. Early studies extend SGMs to tackle class-conditional generation by coupling an unconditional SGM with the…

Computer Vision and Pattern Recognition · Computer Science 2024-02-08 Paul Kuo-Ming Huang , Si-An Chen , Hsuan-Tien Lin

Score-based generative models (SGMs) have proven to be powerful tools for designing new proteins. Designing proteins that bind a pre-specified target is highly relevant to a range of medical and industrial applications. Despite the flurry…

Biomolecules · Quantitative Biology 2024-09-30 John D Boom , Matthew Greenig , Pietro Sormanni , Pietro Liò

The incorporation of generative models as regularisers within variational formulations for inverse problems has proven effective across numerous image reconstruction tasks. However, the resulting optimisation problem is often non-convex and…

Machine Learning · Computer Science 2024-08-14 Pascal Fernsel , Željko Kereta , Alexander Denker

A specific challenge with deep learning approaches for molecule generation is generating both syntactically valid and chemically plausible molecular string representations. To address this, we propose a novel generative latent-variable…

Biomolecules · Quantitative Biology 2024-07-22 Ulrich A. Mbou Sob , Qiulin Li , Miguel Arbesú , Oliver Bent , Andries P. Smit , Arnu Pretorius

Score-based generative modelling (SGM) has proven to be a very effective method for modelling densities on finite-dimensional spaces. In this work we propose to extend this methodology to learn generative models over functional spaces. To…

Generative models are a promising tool to produce cosmological simulations but face significant challenges in scalability, physical consistency, and adherence to domain symmetries, limiting their utility as alternatives to $N$-body…

Cosmology and Nongalactic Astrophysics · Physics 2025-08-26 Diana-Alexandra Onutu , Yue Zhao , Joaquin Vanschoren , Vlado Menkovski

Diffusion models generate samples by denoising along the score of a perturbed target distribution. In practice, one trains a neural diffusion model, which is computationally expensive. Recent work suggests that score matching implicitly…

Machine Learning · Statistics 2026-05-15 Zhenyu Yao , Daniel Paulin

Score-based Generative Models (SGMs) have demonstrated exceptional synthesis outcomes across various tasks. However, the current design landscape of the forward diffusion process remains largely untapped and often relies on physical…

Machine Learning · Computer Science 2023-10-13 Kushagra Pandey , Stephan Mandt