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In computational pathology, automatic nuclei instance segmentation plays an essential role in whole slide image analysis. While many computerized approaches have been proposed for this task, supervised deep learning (DL) methods have shown…

Image and Video Processing · Electrical Eng. & Systems 2023-08-04 Amirreza Mahbod , Christine Polak , Katharina Feldmann , Rumsha Khan , Katharina Gelles , Georg Dorffner , Ramona Woitek , Sepideh Hatamikia , Isabella Ellinger

The clinical management of breast cancer depends on an accurate understanding of the tumor and its anatomical context to adjacent tissues and landmark structures. This context may be provided by semantic segmentation methods; however,…

Image and Video Processing · Electrical Eng. & Systems 2023-11-29 Arda Pekis , Vignesh Kannan , Evandros Kaklamanos , Anu Antony , Snehal Patel , Tyler Earnest

The automated segmentation of cancer tissue in histopathology images can help clinicians to detect, diagnose, and analyze such disease. Different from other natural images used in many convolutional networks for benchmark, histopathology…

Computer Vision and Pattern Recognition · Computer Science 2021-08-06 Juan P. Vigueras-Guillén , Joan Lasenby , Frank Seeliger

Histopathology image analysis can be considered as a Multiple instance learning (MIL) problem, where the whole slide histopathology image (WSI) is regarded as a bag of instances (i.e, patches) and the task is to predict a single class label…

Computer Vision and Pattern Recognition · Computer Science 2019-06-28 Meng Li , Lin Wu , Arnold Wiliem , Kun Zhao , Teng Zhang , Brian C. Lovell

Cell nuclei segmentation is one of the most important tasks in the analysis of biomedical images. With ever-growing sizes and amounts of three-dimensional images to be processed, there is a need for better and faster segmentation methods.…

Computer Vision and Pattern Recognition · Computer Science 2017-02-20 Julian Arz , Peter Sanders , Johannes Stegmaier , Ralf Mikut

Nuclear segmentation, classification and quantification within Haematoxylin & Eosin stained histology images enables the extraction of interpretable cell-based features that can be used in downstream explainable models in computational…

Image and Video Processing · Electrical Eng. & Systems 2022-03-02 Chunhui Lin , Liukun Zhang , Lijian Mao , Min Wu , Dong Hu

From the autonomous car driving to medical diagnosis, the requirement of the task of image segmentation is everywhere. Segmentation of an image is one of the indispensable tasks in computer vision. This task is comparatively complicated…

Computer Vision and Pattern Recognition · Computer Science 2020-06-01 Farhana Sultana , Abu Sufian , Paramartha Dutta

Segmentation of cell nuclei in microscopy images is a prevalent necessity in cell biology. Especially for three-dimensional datasets, manual segmentation is prohibitively time-consuming, motivating the need for automated methods.…

Computer Vision and Pattern Recognition · Computer Science 2020-02-10 Peter Hirsch , Dagmar Kainmueller

Segmentation of histological images is one of the most crucial tasks for many biomedical analyses including quantification of certain tissue type. However, challenges are posed by high variability and complexity of structural features in…

Computer Vision and Pattern Recognition · Computer Science 2020-07-30 Xiaohang Fu , Tong Liu , Zhaohan Xiong , Bruce H. Smaill , Martin K. Stiles , Jichao Zhao

Nucleus instance segmentation in histology images is crucial for a broad spectrum of clinical applications. Current dominant algorithms rely on regression of nuclear proxy maps. Distinguishing nucleus instances from the estimated maps…

Computer Vision and Pattern Recognition · Computer Science 2024-01-25 Zhongyi Shui , Yunlong Zhang , Kai Yao , Chenglu Zhu , Sunyi Zheng , Jingxiong Li , Honglin Li , Yuxuan Sun , Ruizhe Guo , Lin Yang

Automatic segmentation of hepatic lesions in computed tomography (CT) images is a challenging task to perform due to heterogeneous, diffusive shape of tumors and complex background. To address the problem more and more researchers rely on…

Image and Video Processing · Electrical Eng. & Systems 2019-09-18 Dina B. Efremova , Dmitry A. Konovalov , Thanongchai Siriapisith , Worapan Kusakunniran , Peter Haddawy

Pathological diagnosis is the gold standard for tumor diagnosis, and nucleus instance segmentation is a key step in digital pathology analysis and pathological diagnosis. However, the computational efficiency of the model and the treatment…

Image and Video Processing · Electrical Eng. & Systems 2025-05-09 Shengchun Xiong , Xiangru Li , Yunpeng Zhong , Wanfen Peng

A key challenge in cancer immunotherapy biomarker research is quantification of pattern changes in microscopic whole slide images of tumor biopsies. Different cell types tend to migrate into various tissue compartments and form variable…

Computer Vision and Pattern Recognition · Computer Science 2018-09-25 Amal Lahiani , Jacob Gildenblat , Irina Klaman , Nassir Navab , Eldad Klaiman

Digital pathology and microscopy image analysis are widely employed in the segmentation of digitally scanned IHC slides, primarily to identify cancer and pinpoint regions of interest (ROI) indicative of tumor presence. However, current ROI…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Akash Modi , Sumit Kumar Jha , Purnendu Mishra , Rajiv Kumar , Kiran Aatre , Gursewak Singh , Shubham Mathur

Advances in fluorescence microscopy enable acquisition of 3D image volumes with better image quality and deeper penetration into tissue. Segmentation is a required step to characterize and analyze biological structures in the images and…

Computer Vision and Pattern Recognition · Computer Science 2019-04-16 Chichen Fu , Soonam Lee , David Joon Ho , Shuo Han , Paul Salama , Kenneth W. Dunn , Edward J. Delp

Instance segmentation of biological images is essential for studying object behaviors and properties. The challenges, such as clustering, occlusion, and adhesion problems of the objects, make instance segmentation a non-trivial task.…

Computer Vision and Pattern Recognition · Computer Science 2019-11-22 Jingru Yi , Hui Tang , Pengxiang Wu , Bo Liu , Daniel J. Hoeppner , Dimitris N. Metaxas , Lianyi Han , Wei Fan

Hispathological image segmentation algorithms play a critical role in computer aided diagnosis technology. The development of weakly supervised segmentation algorithm alleviates the problem of medical image annotation that it is…

Computer Vision and Pattern Recognition · Computer Science 2022-05-19 Ziniu Qian , Kailu Li , Maode Lai , Eric I-Chao Chang , Bingzheng Wei , Yubo Fan , Yan Xu

One of the most effective ways to treat liver cancer is to perform precise liver resection surgery, the key step of which includes precise digital image segmentation of the liver and its tumor. However, traditional liver parenchymal…

Other Quantitative Biology · Quantitative Biology 2024-06-11 Danyi Huang , Ziang Liu , Yizhou Li

Object detection or localization is an incremental step in progression from coarse to fine digital image inference. It not only provides the classes of the image objects, but also provides the location of the image objects which have been…

Computer Vision and Pattern Recognition · Computer Science 2020-07-07 Abdul Mueed Hafiz , Ghulam Mohiuddin Bhat