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Soft-tissue deformation remains a major limitation in image-guided neurosurgery, where intra-operative anatomy can deviate substantially from pre-operative imaging due to brain shift, compromising navigation accuracy and surgical safety.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Eashrat Jahan Muniya , Gernot Kronreif , Ander Biguri , Wolfgang Birkfellner , Sepideh Hatamikia

Accurate anatomical labeling and analysis of the pulmonary structure and its surrounding anatomy from thoracic CT is getting increasingly important for understanding the etilogy of abnormalities or supporting targetted therapy and early…

Image and Video Processing · Electrical Eng. & Systems 2025-05-09 Minghui Zhang , Chenyu Li , Fangfang Xie , Yaoyu Liu , Hanxiao Zhang , Junyang Wu , Chunxi Zhang , Jie Yang , Jiayuan Sun , Guang-Zhong Yang , Yun Gu

We introduce HyperMorph, a framework that facilitates efficient hyperparameter tuning in learning-based deformable image registration. Classical registration algorithms perform an iterative pair-wise optimization to compute a deformation…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Andrew Hoopes , Malte Hoffmann , Douglas N. Greve , Bruce Fischl , John Guttag , Adrian V. Dalca

In medical imaging, most of the image registration methods implicitly assume a one-to-one correspondence between the source and target images (i.e., diffeomorphism). However, this is not necessarily the case when dealing with pathological…

Image and Video Processing · Electrical Eng. & Systems 2022-02-03 Matthis Maillard , Anton François , Joan Glaunès , Isabelle Bloch , Pietro Gori

We present a new unsupervised learning algorithm, "FAIM", for 3D medical image registration. With a different architecture than the popular "U-net", the network takes a pair of full image volumes and predicts the displacement fields needed…

Computer Vision and Pattern Recognition · Computer Science 2019-07-02 Dongyang Kuang , Tanya Schmah

Diffeomorphic deformable image registration ensures smooth invertible transformations across inspiratory and expiratory chest CT scans. Yet, in practice, deep learning-based diffeomorphic methods struggle to capture large deformations…

Image and Video Processing · Electrical Eng. & Systems 2024-11-13 Muhammad F. A. Chaudhary , Stephanie M. Aguilera , Arie Nakhmani , Joseph M. Reinhardt , Surya P. Bhatt , Sandeep Bodduluri

In recent years, learning-based image registration methods have gradually moved away from direct supervision with target warps to instead use self-supervision, with excellent results in several registration benchmarks. These approaches…

Computer Vision and Pattern Recognition · Computer Science 2022-05-17 Sean I. Young , Yaël Balbastre , Adrian V. Dalca , William M. Wells , Juan Eugenio Iglesias , Bruce Fischl

Image registration is a fundamental technique in the analysis of longitudinal and multi-phase CT images within clinical practice. However, most existing methods are tailored for single-organ applications, limiting their generalizability to…

This work proposes NePhi, a generalizable neural deformation model which results in approximately diffeomorphic transformations. In contrast to the predominant voxel-based transformation fields used in learning-based registration…

Computer Vision and Pattern Recognition · Computer Science 2024-09-30 Lin Tian , Hastings Greer , Raúl San José Estépar , Roni Sengupta , Marc Niethammer

Image registration is a fundamental medical image analysis task. Ideally, registration should focus on aligning semantically corresponding voxels, i.e., the same anatomical locations. However, existing methods often optimize similarity…

Computer Vision and Pattern Recognition · Computer Science 2024-02-27 Lin Tian , Zi Li , Fengze Liu , Xiaoyu Bai , Jia Ge , Le Lu , Marc Niethammer , Xianghua Ye , Ke Yan , Daikai Jin

Deformable image registration (DIR) is essential for many image-guided therapies. Recently, deep learning approaches have gained substantial popularity and success in DIR. Most deep learning approaches use the so-called mono-stream…

Image and Video Processing · Electrical Eng. & Systems 2020-12-08 Zhe Xu , Jie Luo , Jiangpeng Yan , Xiu Li , Jagadeesan Jayender

We present WSSAMNet, a weakly supervised method for medical image registration. Ours is a two step method, with the first step being the computation of segmentation masks of the fixed and moving volumes. These masks are then used to attend…

Image and Video Processing · Electrical Eng. & Systems 2022-03-15 Sahar Almahfouz Nasser , Nikhil Cherian Kurian , Saqib Shamsi , Mohit Meena , Amit Sethi

Diffeomorphic image registration, offering smooth transformation and topology preservation, is required in many medical image analysis tasks.Traditional methods impose certain modeling constraints on the space of admissible transformations…

Computer Vision and Pattern Recognition · Computer Science 2022-11-03 Kun Han , Shanlin sun , Xiangyi Yan , Chenyu You , Hao Tang , Junayed Naushad , Haoyu Ma , Deying Kong , Xiaohui Xie

Surgical navigation based on multimodal image registration has played a significant role in providing intraoperative guidance to surgeons by showing the relative position of the target area to critical anatomical structures during surgery.…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Jiazheng Wang , Zeyu Liu , Min Liu , Xiang Chen , Xinyao Yu , Yaonan Wang , Hang Zhang

Deformable registration of two-dimensional/three-dimensional (2D/3D) images of abdominal organs is a complicated task because the abdominal organs deform significantly and their contours are not detected in two-dimensional X-ray images. We…

Image and Video Processing · Electrical Eng. & Systems 2022-12-13 Ryuto Miura , Megumi Nakao , Mitsuhiro Nakamura , Tetsuya Matsuda

This paper presents a novel predictive model, MetaMorph, for metamorphic registration of images with appearance changes (i.e., caused by brain tumors). In contrast to previous learning-based registration methods that have little or no…

Computer Vision and Pattern Recognition · Computer Science 2023-03-10 Jian Wang , Jiarui Xing , Jason Druzgal , William M. Wells , Miaomiao Zhang

Due to their extreme long-range modeling capability, vision transformer-based networks have become increasingly popular in deformable image registration. We believe, however, that the receptive field of a 5-layer convolutional U-Net is…

Image and Video Processing · Electrical Eng. & Systems 2022-08-16 Xi Jia , Joseph Bartlett , Tianyang Zhang , Wenqi Lu , Zhaowen Qiu , Jinming Duan

Deformable image registration (alignment) is highly sought after in numerous clinical applications, such as computer aided diagnosis and disease progression analysis. Deep Convolutional Neural Network (DCNN)-based image registration methods…

Image and Video Processing · Electrical Eng. & Systems 2024-05-17 Ruizhe Li , Grazziela Figueredo , Dorothee Auer , Christian Wagner , Xin Chen

Ultrasound Localization Microscopy (ULM) can map microvessels at a resolution of a few micrometers (\mu m). Transcranial ULM remains challenging in presence of aberrations caused by the skull, which lead to localization errors. Herein, we…

Image and Video Processing · Electrical Eng. & Systems 2023-09-20 Paul Xing , Jonathan Porée , Brice Rauby , Antoine Malescot , Éric Martineau , Vincent Perrot , Ravi L. Rungta , Jean Provost

Accurate registration of brain MRI scans is fundamental for cross-subject analysis in neuroscientific studies. This involves aligning both the cortical surface of the brain and the interior volume. Traditional methods treat volumetric and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-24 S. Mazdak Abulnaga , Andrew Hoopes , Malte Hoffmann , Robin Magnet , Maks Ovsjanikov , Lilla Zöllei , John Guttag , Bruce Fischl , Adrian Dalca