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In order to study the molecular damage induced in the form of single-strand and double-strand breaks by the ionizing radiation at the DNA level, Geant4-DNA Monte Carlo simulation code for complete transportation of primary protons and other…

Biological Physics · Physics 2018-10-10 Mojtaba Mokari , Mohammad Hassan Alamatsaz , Hossein Moeini , Reza Taleei

The stability and dynamics of a double-stranded DNA (dsDNA) is affected by the preferential occupancy of small monovalent molecular ions. Small metal and molecular ions such as sodium and alkyl ammonium have crucial biological functions in…

Soft Condensed Matter · Physics 2015-08-25 Soumadwip Ghosh , Mayank Kumar Dixit , Rajarshi Chakrabarti

We study the nonlinear dynamics of a deformed Deoxyribonucleic acid (DNA) molecular chain which is governed by a perturbed sine-Gordon equation coupled with a linear wave equation representing the lattice deformation. The DNA chain…

Pattern Formation and Solitons · Physics 2009-11-13 V. Vasumathi , M. Daniel

Structural and functional information encoded in DNA combined with unique properties of nanomaterials could be of use for the construction of novel biocomputational circuits and intelligent biomedical nanodevices. However, at present their…

Materials Science · Physics 2013-07-16 Jun Zhang , Cuong Cao , Xinlong Xu , Chihao Liow , Shuzhou Li , Ping-Heng Tan , Qihua Xiong

We study the electronic properties of DNA by way of a tight-binding model applied to four particular DNA sequences. The charge transfer properties are presented in terms of localisation lengths, crudely speaking the length over which…

Genomics · Quantitative Biology 2007-05-23 Daphne Klotsa , Rudolf A. Roemer , Matthew S. Turner

Hand-sized Deoxyribonucleic acid (DNA) sequencing machines are of growing importance in several life sciences fields as their small footprints enable a broader range of use cases than their larger, stationary counterparts. However, as…

Hardware Architecture · Computer Science 2025-10-13 Abel Beyene , Zhongpan Wu , Yunus Dawji , Karim Hammad , Ebrahim Ghafar-Zadeh , Sebastian Magierowski

Quantization is commonly used in Deep Neural Networks (DNNs) to reduce the storage and computational complexity by decreasing the arithmetical precision of activations and weights, a.k.a. tensors. Efficient hardware architectures employ…

Machine Learning · Computer Science 2023-11-23 Bahareh Khabbazan , Marc Riera , Antonio González

The diversity and heterogeneity of biomarkers has made the development of general methods for single-step quantification of analytes difficult. For individual biomarkers, electrochemical methods that detect a conformational change in an…

The approach for the description of the DNA conformational transformations on the mesoscopic scales in the frame of the double helix is presented. Due to consideration of the joint motions of DNA structural elements along the conformational…

Biomolecules · Quantitative Biology 2009-09-29 S. N. Volkov

When the DNA double helix is subjected to external forces it can stretch elastically to elongations reaching 100% of its natural length. These distortions, imposed at the mesoscopic or macroscopic scales, have a dramatic effect on…

Materials Science · Physics 2009-11-13 Ryan Barnett , Paul Maragakis , Ari Turner , Maria Fyta , Efthimios Kaxiras

Understanding the three-dimensional (3D) structure and stability of DNA is fundamental for its biological function and the design of novel drugs. In this study, we introduce an improved coarse-grained (CG) model, incorporating a more…

Soft Condensed Matter · Physics 2025-01-22 Xunxun Wang , Ya-Zhou Shi

The lack of molecular-level understanding for the electronic excitation response of DNA to charged particle radiation, such as high-energy protons, remains a fundamental scientific bottleneck in advancing proton and other ion beam cancer…

Soft Condensed Matter · Physics 2023-03-17 Christopher Shepard , Dillon Yost , Yosuke Kanai

We describe a strategy for constructing codes for DNA-based information storage by serial composition of weighted finite-state transducers. The resulting state machines can integrate correction of substitution errors; synchronization by…

Information Theory · Computer Science 2016-11-18 Ian Holmes

The passage of DNA through a nanopore can be effectively decomposed into two distinct phases, docking and actual translocation. In experiments each phase is characterized by a distinct current signature which allows the discrimination of…

Cytosine methylation has been found to play a crucial role in various biological processes, including a number of human diseases. The detection of this small modification remains challenging. In this work, we computationally explore the…

Biological Physics · Physics 2017-02-21 Jianqing Qi , Niranjan Govind , M. P. Anantram

$Objective:$ Information on the metabolism of tissues in both healthy and diseased states plays a significant role in the detection and understanding of tumors, neurodegenerative diseases, diabetes, and other metabolic disorders.…

Medical Physics · Physics 2023-10-27 Komlan Payne , Yunkun Zhao , Aditya Ashok Bhosale , Xiaoliang Zhang

Deterministic control of excitonic properties is key to advancing nanoscale optoelectronic and quantum technologies and to understanding diverse physical, optical, chemical, and biological phenomena. At the molecular scale, these properties…

The intrinsic double helix conformation of the DNA strands is known to be the key ingredient of control of the electric current through the DNA by the perpendicular (gate) electric field. We show theoretically that Bloch oscillations in the…

Materials Science · Physics 2009-10-25 A. V. Malyshev , V. A. Malyshev , F. Dominguez-Adame

In recent years, significant progress in understanding the properties of supercoiled DNA has been obtained due to nanotechniques that made stretching and twisting of single molecules possible. Quantitative interpretation of such experiments…

Biomolecules · Quantitative Biology 2015-06-05 Alexey K. Mazur

The way nuclear motion affects electronic responses has become a very hot topic in materials science. Coherent acoustic phonons can dynamically modify optical, magnetic and mechanical properties at ultrasonic frequencies, with promising…

Mesoscale and Nanoscale Physics · Physics 2018-08-29 Edoardo Baldini , Tania Palmieri , Adriel Dominguez , Pascal Ruello , Angel Rubio , Majed Chergui