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Automated molecular structure elucidation remains challenging, as existing approaches often depend on pre-compiled databases or restrict themselves to single spectroscopic modalities. Here we introduce SpectraLLM, a large language model…

Quantitative Methods · Quantitative Biology 2026-05-12 Yunyue Su , Jiahui Chen , Zao Jiang , Zhenyi Zhong , Liang Wang , Qiang Liu , Zhaoxiang Zhang

Improving the detailed understanding of the underlying properties and functions of biomolecules has recently attracted growing interest, enabled by the possibility of real-space imaging of single, intact macromolecules using Scanning…

Mesoscale and Nanoscale Physics · Physics 2026-03-10 Tim J. Seifert , Dhaneesh Kumar , Markus Etzkorn , Stephan Rauschenbach , Klaus Kern , Kelvin Anggara , Uta Schlickum

Molecular fluorescence microscopy is a leading approach to super-resolution and nanoscale imaging in life and material sciences. However, super-resolution fluorescence microscopy is often bottlenecked by system-specific calibrations and…

We propose a simple yet effective model for Single Image Super-Resolution (SISR), by combining the merits of Residual Learning and Convolutional Sparse Coding (RL-CSC). Our model is inspired by the Learned Iterative Shrinkage-Threshold…

Computer Vision and Pattern Recognition · Computer Science 2019-01-01 Menglei Zhang , Zhou Liu , Lei Yu

Super-resolution microscopy is providing unprecedented insights into biology by resolving details much below the diffraction limit. State-of-the-art Single Molecule Localization Microscopy (SMLM) techniques for super-resolution are…

Quantitative Methods · Quantitative Biology 2016-12-13 Krishna Agarwal , Radek Macháň

Weakly supervised object localization(WSOL) remains an open problem given the deficiency of finding object extent information using a classification network. Although prior works struggled to localize objects through various spatial…

Computer Vision and Pattern Recognition · Computer Science 2021-03-31 Xingjia Pan , Yingguo Gao , Zhiwen Lin , Fan Tang , Weiming Dong , Haolei Yuan , Feiyue Huang , Changsheng Xu

Single image super-resolution (SISR) aims to obtain a high-resolution output from one low-resolution image. Currently, deep learning-based SISR approaches have been widely discussed in medical image processing, because of their potential to…

Image and Video Processing · Electrical Eng. & Systems 2021-05-25 Jin Zhu , Chuan Tan , Junwei Yang , Guang Yang , Pietro Lio'

Single-beam super-resolution microscopy, also known as superlinear microscopy, exploits the nonlinear response of fluorescent probes in confocal microscopy. The technique requires no complex purpose-built system, light field modulation, or…

Spectroscopic techniques are essential tools for determining the structure of molecules. Different spectroscopic techniques, such as Nuclear magnetic resonance (NMR), Infrared spectroscopy, and Mass Spectrometry, provide insight into the…

Chemical Physics · Physics 2024-10-30 Marvin Alberts , Oliver Schilter , Federico Zipoli , Nina Hartrampf , Teodoro Laino

Motivation: Structural heterogeneity in single-particle cryo-electron microscopy (cryo-EM) data represents a major challenge for high-resolution structure determination. Unsupervised classification may serve as the first step in the…

Data Analysis, Statistics and Probability · Physics 2017-11-01 Jiayi Wu , Yong-Bei Ma , Charles Congdon , Bevin Brett , Shuobing Chen , Qi Ouyang , Youdong Mao

Human physiology and pathology arise from the coordinated interactions of diverse single cells. However, analyzing single cells has been limited by the low sensitivity and throughput of analytical methods. DNA sequencing has recently made…

Quantitative Methods · Quantitative Biology 2020-06-23 Nikolai Slavov

Radiological images such as computed tomography (CT) and X-rays render anatomy with intrinsic structures. Being able to reliably locate the same anatomical structure across varying images is a fundamental task in medical image analysis. In…

Computer Vision and Pattern Recognition · Computer Science 2023-10-24 Ke Yan , Jinzheng Cai , Dakai Jin , Shun Miao , Dazhou Guo , Adam P. Harrison , Youbao Tang , Jing Xiao , Jingjing Lu , Le Lu

Magnetic Resonance Imaging (MRI) is a leading diagnostic modality for a wide range of exams, where multiple contrast images are often acquired for characterizing different tissues. However, acquiring high-resolution MRI typically extends…

Image and Video Processing · Electrical Eng. & Systems 2024-08-07 Shaoming Zheng , Yinsong Wang , Siyi Du , Chen Qin

The deep convolutional neural networks have achieved significant improvements in accuracy and speed for single image super-resolution. However, as the depth of network grows, the information flow is weakened and the training becomes harder…

Computer Vision and Pattern Recognition · Computer Science 2018-02-27 Yanting Hu , Xinbo Gao , Jie Li , Yuanfei Huang , Hanzi Wang

Single-beam scanning microscopy (SBSM) is one of the most robust strategies for commercial optical systems. Although structured illumination combined with Fourier-domain spatial spectrum fusion can enhance SBSM resolution beyond the…

Optics · Physics 2025-07-15 Yongtao Liu , Tianxiao Wu , Xiao Zhou , Fan Wang

Scanning tunnelling microscopy (STM) is a powerful technique for imaging surfaces with atomic resolution, providing insight into physical and chemical processes at the level of single atoms and molecules. A regular task of STM image…

Super-resolution microscopy has catalyzed valuable insights into the sub-cellular, mechanistic details of many different biological processes across a wide range of cell types. Fluorescence polarization spectroscopy tools have also enabled…

Biological Physics · Physics 2023-01-25 Jack W Shepherd , Alex L Payne-Dwyer , Ji-Eun Lee , Aisha Syeda , Mark C Leake

Microstructure of materials is often characterized through image analysis to understand processing-structure-properties linkages. We propose a largely automated framework that integrates unsupervised and supervised learning methods to…

Applications · Statistics 2025-09-05 Kungang Zhang , Wei Chen , Wing K. Liu , L. Catherine Brinson , Daniel W. Apley

A non-linear system governed by multi-spatial and multi-temporal physics scales cannot be fully understood with a single diagnostic, as each provides only a partial view, leading to information loss. Combining multiple diagnostics may also…

Image Phase Alignment Super-Sampling (ImPASS) is a computational imaging algorithm for converting a sequence of displaced low-resolution images into a single high-resolution image. The method consists of a unique combination of Phase…

Optics · Physics 2025-09-01 James N. Caron