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Predicting the release performance of a drug delivery device is an important challenge in pharmaceutics and biomedical science. In this paper, we consider a multi-layer diffusion model of drug release from a composite spherical microcapsule…

Medical Physics · Physics 2019-01-25 Elliot J. Carr , Giuseppe Pontrelli

We estimate the distribution of random parameters in a distributed parameter model with unbounded input and output for the transdermal transport of ethanol in humans. The model takes the form of a diffusion equation with the input being the…

Optimization and Control · Mathematics 2018-08-14 Melike Sirlanci , Susan E. Luczak , Catharine E. Fairbairn , Dahyeon Kang , Ruoxi Pan , Xin Yu , I. G. Rosen

Consider a particle diffusing in a confined volume which is divided into two equal regions. In one region the diffusion coefficient is twice the value of the diffusion coefficient in the other region. Will the particle spend equal…

Dynamical Systems · Mathematics 2015-06-04 P. F. Tupper , Xin Yang

We present a mechanistic model of drug release from a multiple emulsion into an external surrounding fluid. We consider a single multi-layer droplet where the drug kinetics are described by a pure diffusive process through different liquid…

Soft Condensed Matter · Physics 2020-09-02 G. Pontrelli , E. J. Carr , A. Tiribocchi , S. Succi

We present a general mechanistic model of mass diffusion for a composite sphere placed in a large ambient medium. The multi-layer problem is described by a system of diffusion equations coupled via interlayer boundary conditions such as…

Medical Physics · Physics 2018-01-17 Elliot J. Carr , Giuseppe Pontrelli

In this paper, we investigate the use of a mass lumped fully explicit time stepping scheme for the discretisation of the wave equation with underlying material parameters that vary at arbitrarily fine scales. We combine the leapfrog scheme…

Numerical Analysis · Mathematics 2021-09-08 Sjoerd Geevers , Roland Maier

External matching networks are crucial and necessary for operating capacitively coupled plasmas in order to maximize the absorbed power. Experiments show that external circuits in general heavily interact with the plasma in a nonlinear way.…

Plasma Physics · Physics 2018-11-15 Frederik Schmidt , Thomas Mussenbrock , Jan Trieschmann

In this paper, we derive an effective model for transport processes in periodically perforated elastic media, taking into account, e.g., cyclic elastic deformations as they occur in lung tissue due to respiratory movement. The underlying…

Analysis of PDEs · Mathematics 2022-06-15 Jonas Knoch , Markus Gahn , Maria Neuss-Radu , Nicolas Neuß

This paper focuses on multiscale dynamics occurring in steam supply systems. The dynamics of interest are originally described by a distributed-parameter model for fast steam flows over a pipe network coupled with a lumped-parameter model…

Dynamical Systems · Mathematics 2023-05-15 Hikaru Hoshino , Yoshihiko Susuki , Takashi Hikihara

We consider a linear diffusion equation on $\Omega:=\mathbb{R}^2\setminus\bar{\Omega_\mathcal{O}}$, where $\Omega_\mathcal{O}$ is a bounded domain. The time-dependent flux on the boundary $\Gamma:=\partial\Omega_\mathcal{O}$ is prescribed.…

Analysis of PDEs · Mathematics 2014-10-14 Joep H. M. Evers , Sander C. Hille , Adrian Muntean

Several natural and industrial processes involve the extraction or retention of a solute by a fluid invading a network of channels. Examples include aquifer contamination, chemical filtration, and coffee extraction. We propose a continuum…

We study a cellular automaton model, which allows diffusion of energy (or equivalently any other physical quantities such as mass of a particular compound) at every lattice site after each timestep. Unit amount of energy is randomly added…

Condensed Matter · Physics 2009-10-22 T. C. Chan , H. F. Chau , K. S. Cheng

A consolidated mathematical formulation of the spherically symmetric mass-transfer problem is presented, with the quasi-stationary approximating equations derived from a perturbation point of view for the leading-order effect. For the…

Mathematical Physics · Physics 2012-09-24 James Q. Feng

We study mass fluxes in aggregation models where mass transfer to large scales by aggregation occurs alongside desorption or fragmentation. Two models are considered. (1) A system of diffusing, aggregating particles with influx and outflux…

Statistical Mechanics · Physics 2009-11-13 Colm Connaughton , R. Rajesh , Oleg Zaboronski

We present a multiscale approach to model diffusion in a crowded environment and its effect on the reaction rates. Diffusion in biological systems is often modeled by a discrete space jump process in order to capture the inherent noise of…

Subcellular Processes · Quantitative Biology 2016-03-18 Lina Meinecke

We consider the classical problem of particle diffusion in $d$-dimensional radially-symmetric systems with absorbing boundaries. A key quantity to characterise such diffusive transport is the evolution of the proportion of particles…

Computational Physics · Physics 2022-09-07 Elliot J. Carr

Diffusive molecular dynamics is a novel model for materials with atomistic resolution that can reach diffusive time scales. The main ideas of diffusive molecular dynamics are to first minimize an approximate variational Gaussian free energy…

Numerical Analysis · Mathematics 2015-06-09 Gideon Simpson , Mitchell Luskin , David J. Srolovitz

We propose a mathematical model for computing drug release from multi-layer capsules. The diffusion problem in such heterogeneous layer-by-layer composite medium is described by a system of coupled partial differential equations, which we…

Medical Physics · Physics 2017-08-04 Badr Kaoui , Marco Lauricella , Giuseppe Pontrelli

A spatio-temporal evolution of chemicals appearing in a reversible enzyme reaction and modelled by a four component reaction-diffusion system with the reaction terms obtained by the law of mass action is considered. The large time behaviour…

Analysis of PDEs · Mathematics 2016-10-25 Jan Elias

The multipole expansion is a key tool in the study of light-matter interactions. All the information about the radiation of and coupling to electromagnetic fields of a given charge-density distribution is condensed into few numbers: The…

Optics · Physics 2018-05-08 R. Alaee , C. Rockstuhl , I. Fernandez-Corbaton
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