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Purpose: Various dose calculation algorithms are available for radiation therapy for cancer patients. However, these algorithms are faced with the tradeoff between efficiency and accuracy. The fast algorithms are generally less accurate,…

Medical Physics · Physics 2020-07-01 Yixun Xing , Dan Nguyen , Weiguo Lu , Ming Yang , Steve Jiang

The primary goal of reinforcement learning is to develop decision-making policies that prioritize optimal performance without considering risk or safety. In contrast, safe reinforcement learning aims to mitigate or avoid unsafe states. This…

Machine Learning · Computer Science 2024-09-13 Zahra Shahrooei , Ali Baheri

Offline reinforcement learning enables agents to leverage large pre-collected datasets of environment transitions to learn control policies, circumventing the need for potentially expensive or unsafe online data collection. Significant…

Machine Learning · Computer Science 2022-03-17 Cong Lu , Philip J. Ball , Jack Parker-Holder , Michael A. Osborne , Stephen J. Roberts

In order perform a large variety of tasks and to achieve human-level performance in complex real-world environments, Artificial Intelligence (AI) Agents must be able to learn from their past experiences and gain both knowledge and an…

Machine Learning · Computer Science 2019-05-13 Andrei Claudiu Roibu

In this paper we present an online wide-area oscillation damping control (WAC) design for uncertain models of power systems using ideas from reinforcement learning. We assume that the exact small-signal model of the power system at the…

Systems and Control · Computer Science 2018-10-02 Amirhassan Fallah Dizche , Aranya Chakrabortty , Alexandra Duel-Hallen

A growing body of evidence suggests that neural networks employed in deep reinforcement learning (RL) gradually lose their plasticity, the ability to learn from new data; however, the analysis and mitigation of this phenomenon is hampered…

Machine Learning · Computer Science 2023-10-05 Evgenii Nikishin , Junhyuk Oh , Georg Ostrovski , Clare Lyle , Razvan Pascanu , Will Dabney , André Barreto

Pharmacological challenge imaging has mapped, but rarely quantified, the sensitivity of a biological system to a given drug. We describe a novel method called rapid quantitative pharmacodynamic imaging. This method combines…

Quantitative Methods · Quantitative Biology 2014-05-28 Kevin J. Black , Jonathan M. Koller , Brad D. Miller

Deep Learning algorithms, such as those used in Reinforcement Learning, often require large quantities of data to train effectively. In most cases, the availability of data is not a significant issue. However, for some contexts, such as in…

Quantum Physics · Physics 2024-09-02 Daniel Kent , Clement O'Rourke , Jake Southall , Kirsty Duncan , Adrian Bedford

Reinforcement learning (RL) struggles to scale to large, combinatorial action spaces common in many real-world problems. This paper introduces a novel framework for training discrete diffusion models as highly effective policies in these…

Machine Learning · Computer Science 2026-05-21 Haitong Ma , Ofir Nabati , Aviv Rosenberg , Bo Dai , Oran Lang , Craig Boutilier , Na Li , Shie Mannor , Lior Shani , Guy Tenneholtz

Deep reinforcement learning algorithms that learn policies by trial-and-error must learn from limited amounts of data collected by actively interacting with the environment. While many prior works have shown that proper regularization…

Machine Learning · Computer Science 2023-04-21 Qiyang Li , Aviral Kumar , Ilya Kostrikov , Sergey Levine

In a Phase II dose-finding study with a placebo control, a new drug with several dose levels is compared with a placebo to test for the effectiveness of the new drug. The main focus of such studies often lies in the characterization of the…

Methodology · Statistics 2020-07-14 Saswati Saha , Werner Brannath

Deep reinforcement learning (DRL) requires the collection of interventional data, which is sometimes expensive and even unethical in the real world, such as in the autonomous driving and the medical field. Offline reinforcement learning…

Machine Learning · Computer Science 2023-06-12 Wenxuan Zhu , Chao Yu , Qiang Zhang

Order picking is a pivotal operation in warehouses that directly impacts overall efficiency and profitability. This study addresses the dynamic order picking problem, a significant concern in modern warehouse management, where real-time…

Optimization and Control · Mathematics 2025-04-08 Sasan Mahmoudinazlou , Abhay Sobhanan , Hadi Charkhgard , Ali Eshragh , George Dunn

Recent advances in deep learning frameworks have established valuable tools for analyzing the long-timescale behavior of complex systems such as proteins. Especially the inclusion of physical constraints, e.g. time-reversibility, was a…

Quantitative Methods · Quantitative Biology 2021-12-22 Andreas Mardt , Frank Noé

In clinical treatment, identifying potential adverse reactions of drugs can help assist doctors in making medication decisions. In response to the problems in previous studies that features are high-dimensional and sparse, independent…

Quantitative Methods · Quantitative Biology 2024-07-30 Yufeng Li , Wenchao Zhao , Bo Dang , Xu Yan , Weimin Wang , Min Gao , Mingxuan Xiao

Empirical design in reinforcement learning is no small task. Running good experiments requires attention to detail and at times significant computational resources. While compute resources available per dollar have continued to grow…

Machine Learning · Computer Science 2024-10-30 Andrew Patterson , Samuel Neumann , Martha White , Adam White

Despite the efficacy on a variety of computer vision tasks, deep neural networks (DNNs) are vulnerable to adversarial attacks, limiting their applications in security-critical systems. Recent works have shown the possibility of generating…

Computer Vision and Pattern Recognition · Computer Science 2018-12-21 Ziang Yan , Yiwen Guo , Changshui Zhang

Drug combination therapy is a well-established strategy for disease treatment with better effectiveness and less safety degradation. However, identifying novel drug combinations through wet-lab experiments is resource intensive due to the…

Machine Learning · Computer Science 2023-01-18 Zhihang Hu , Qinze Yu , Yucheng Guo , Taifeng Wang , Irwin King , Xin Gao , Le Song , Yu Li

Adversarial data can lead to malfunction of deep learning applications. It is essential to develop deep learning models that are robust to adversarial data while accurate on standard, clean data. In this study, we proposed a novel…

Image and Video Processing · Electrical Eng. & Systems 2024-02-15 Degan Hao , Dooman Arefan , Margarita Zuley , Wendie Berg , Shandong Wu

Robust Reinforcement Learning aims to find the optimal policy with some extent of robustness to environmental dynamics. Existing learning algorithms usually enable the robustness through disturbing the current state or simulating…

Machine Learning · Computer Science 2020-06-02 Linfang Hou , Liang Pang , Xin Hong , Yanyan Lan , Zhiming Ma , Dawei Yin
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