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Motivated by the growing availability of personal genomics services, we study an information-theoretic privacy problem that arises when sharing genomic data: a user wants to share his or her genome sequence while keeping the genotypes at…

Information Theory · Computer Science 2021-10-18 Fangwei Ye , Hyunghoon Cho , Salim El Rouayheb

Genome sequencing technology has advanced at a rapid pace and it is now possible to generate highly-detailed genotypes inexpensively. The collection and analysis of such data has the potential to support various applications, including…

Cryptography and Security · Computer Science 2015-06-18 Muhammad Naveed , Erman Ayday , Ellen W. Clayton , Jacques Fellay , Carl A. Gunter , Jean-Pierre Hubaux , Bradley A. Malin , XiaoFeng Wang

We propose a novel mechanism for answering sets of count- ing queries under differential privacy. Given a workload of counting queries, the mechanism automatically selects a different set of "strategy" queries to answer privately, using…

Databases · Computer Science 2012-02-20 Chao Li , Gerome Miklau

Capturing the vast amount of meaningful information encoded in the human genome is a fascinating research problem. The outcome of these researches have significant influences in a number of health related fields --- personalized medicine,…

Cryptography and Security · Computer Science 2017-03-07 Mohammad Zahidul Hasan , Md Safiur Rahman Mahdi , Noman Mohammed

In this paper, we consider the problem of responding to a count query (or any other integer-valued queries) evaluated on a dataset containing sensitive attributes. To protect the privacy of individuals in the dataset, a standard practice is…

Information Theory · Computer Science 2020-07-21 Parastoo Sadeghi , Shahab Asoodeh , Flavio du Pin Calmon

Many data applications involve counting queries, where a client specifies a feasible range of variables and a database returns the corresponding item counts. A program that produces the counts of different queries often risks leaking…

Databases · Computer Science 2025-09-10 Jun Gao , Jie Ding

Concern about how to aggregate sensitive user data without compromising individual privacy is a major barrier to greater availability of data. The model of differential privacy has emerged as an accepted model to release sensitive…

Databases · Computer Science 2017-10-03 Graham Cormode , Tejas Kulkarni , Divesh Srivastava

Motivation: Researchers need a rich trove of genomic datasets that they can leverage to gain a better understanding of the genetic basis of the human genome and identify associations between phenotypes and specific parts of DNA. However,…

Cryptography and Security · Computer Science 2021-06-10 Nour Almadhoun Alserr , Gulce Kale , Onur Mutlu , Oznur Tastan , Erman Ayday

Recent advances in DNA sequencing technologies have put ubiquitous availability of fully sequenced human genomes within reach. It is no longer hard to imagine the day when everyone will have the means to obtain and store one's own DNA…

Cryptography and Security · Computer Science 2015-03-19 Pierre Baldi , Roberta Baronio , Emiliano De Cristofaro , Paolo Gasti , Gene Tsudik

Differential privacy is a mathematical notion of data privacy that has fast become the de facto standard in privacy-preserving data analysis. Recently a lot of work has focused on differential privacy in the quantum setting. Continuing on…

Quantum Physics · Physics 2026-04-14 Arghya Mukherjee , Hassan Jameel Asghar , Gavin K. Brennen

Existing studies on differential privacy mainly consider aggregation on data sets where each entry corresponds to a particular participant to be protected. In many situations, a user may pose a relational algebra query on a sensitive…

Databases · Computer Science 2013-04-18 Shixi Chen , Shuigeng Zhou

Privacy is of the utmost importance in genomic matching. Therefore a number of privacy-preserving protocols have been presented using secure computation. Nevertheless, none of these protocols prevents inferences from the result. Goodrich…

Cryptography and Security · Computer Science 2014-05-02 Florian Kerschbaum , Martin Beck , Dagmar Schönfeld

Large genomic datasets are now created through numerous activities, including recreational genealogical investigations, biomedical research, and clinical care. At the same time, genomic data has become valuable for reuse beyond their…

Cryptography and Security · Computer Science 2021-12-28 Rajagopal Venkatesaramani , Zhiyu Wan , Bradley A. Malin , Yevgeniy Vorobeychik

A central problem in differentially private data analysis is how to design efficient algorithms capable of answering large numbers of counting queries on a sensitive database. Counting queries of the form "What fraction of individual…

Cryptography and Security · Computer Science 2013-10-02 Jonathan Ullman

Genomic data are becoming increasingly valuable as we develop methods to utilize the information at scale and gain a greater understanding of how genetic information relates to biological function. Advances in synthetic biology and the…

A common goal of privacy research is to release synthetic data that satisfies a formal privacy guarantee and can be used by an analyst in place of the original data. To achieve reasonable accuracy, a synthetic data set must be tuned to…

Databases · Computer Science 2015-03-20 Chao Li , Gerome Miklau

Rapid advances in human genomics are enabling researchers to gain a better understanding of the role of the genome in our health and well-being, stimulating hope for more effective and cost efficient healthcare. However, this also prompts a…

Cryptography and Security · Computer Science 2018-08-20 Alexandros Mittos , Bradley Malin , Emiliano De Cristofaro

We consider the problem of identification and authentication based on secret key generation from some user-generated source data (e.g., a biometric source). The goal is to reliably identify users pre-enrolled in a database as well as…

Information Theory · Computer Science 2015-08-07 Kittipong Kittichokechai , Giuseppe Caire

The availability of genomic data is essential to progress in biomedical research, personalized medicine, etc. However, its extreme sensitivity makes it problematic, if not outright impossible, to publish or share it. As a result, several…

Genomics · Quantitative Biology 2022-01-19 Bristena Oprisanu , Georgi Ganev , Emiliano De Cristofaro

When an individual's DNA is sequenced, sensitive medical information becomes available to the sequencing laboratory. A recently proposed way to hide an individual's genetic information is to mix in DNA samples of other individuals. We…

Information Theory · Computer Science 2024-11-05 Kayvon Mazooji , Roy Dong , Ilan Shomorony
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