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Delineation of tumors and organs-at-risk permits detecting and correcting changes in the patients' anatomy throughout the treatment, making it a core step of adaptive proton therapy (APT). Although AI-based auto-contouring technologies have…

The accuracy of hadrontherapy treatment is currently limited by ion-range uncertainties. In order to fully exploit the potential of this technique, we propose the development of a novel system for online control of particle therapy, based…

Electron-tracking Compton camera, which is a complete Compton camera with tracking Compton scattering electron by a gas micro time projection chamber, is expected to open up MeV gamma-ray astronomy. The technical challenge for achieving…

Superconducting transition-edge sensors (TESs) carried by X-ray telescopes are powerful tools for the study of neutron stars and black holes. Several methods, such as optimal filtering or principal component analysis, have already been…

Purpose: To improve target coverage and reduce the dose in the surrounding organs-at-risks (OARs), we developed an image-guided treatment method based on a precomputed library of treatment plans controlled and delivered in real-time.…

Proton beam therapy can potentially offer improved treatment for cancers of the head and neck and in paediatric patients. There has been a sharp uptake of proton beam therapy in recent years as improved delivery techniques and patient…

Radiotherapy is one of the main methods in the successful treatment of cancer. The tumor is irradiated with photons or charged particles (e.g. protons), and in the case of massive charged particles, the treatment results in less unnecessary…

An advanced Compton telescope appears to be the best instrument concept for the next generation gamma-ray space observatory in the MeV range. A first prototype of advanced Compton telescope is being developed to match the constraints of a…

Compton telescopes provide a good sensitivity over a wide field of view in the difficult energy range running from a few hundred keV to several MeV. Their angular resolution is, however, poor and strongly energy dependent. We present a…

For MeV gamma-ray astronomy, we have developed an electron-tracking Compton camera (ETCC) as a MeV gamma-ray telescope capable of rejecting the radiation background and attaining the high sensitivity of near 1 mCrab in space. Our ETCC…

A high-efficiency fast neutron detector prototype based on a triple Gas Electron Multiplier (GEM) detector, which coupled with a novel multi-layered High-Density PolyEthylene (HDPE) as a neutron-to-proton converter for improving the neutron…

Objective: Proton therapy is a precision-focused cancer treatment where accurate proton beam range monitoring is critical to ensure effective dose delivery. This can be achieved by prompt gamma detection with a Compton camera like the…

Purpose: To demonstrate a proton imaging system based on well-established fast scintillator technology to achieve high performance with low cost and complexity, with the potential of a straightforward translation into clinical use. Methods:…

Intensity-modulated proton therapy (IMPT) employs proton radiation rather than conventional X-rays to treat cancerous tumors. This approach offers significant advantages by minimizing the radiation exposure of surrounding healthy tissue,…

Treatment planning systems at proton-therapy centres generally use X-ray computed tomography (CT) as primary imaging technique to infer the proton treatment doses to tumour and healthy tissues. However, proton stopping powers in the body,…

Due to the inter- and intra- variation of respiratory motion, it is highly desired to provide real-time volumetric images during the treatment delivery of lung stereotactic body radiation therapy (SBRT) for accurate and active motion…

Intensity modulated proton therapy (IMPT) is an advanced cancer treatment modality that offers significant advantages over conventional X-ray therapies, particularly in its ability to minimize radiation dose beyond the tumor target. This…

Dual-energy CT (DECT) has been widely investigated to generate more informative and more accurate images in the past decades. For example, Dual-Energy Alternating Minimization (DEAM) algorithm achieves sub-percentage uncertainty in…

We have developed a compact Compton gamma-ray imager with a large field of view and a low channel-count that is capable of quickly localizing gamma-ray sources in the few hundred keV - several MeV range. The two detector planes (scatter and…

Low-dose positron emission tomography (PET) image reconstruction methods have potential to significantly improve PET as an imaging modality. Deep learning provides a promising means of incorporating prior information into the image…