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To increase statistical efficiency in a randomized experiment, researchers often use stratification (i.e., blocking) in the design stage. However, conventional practices of stratification fail to exploit valuable information about the…

Methodology · Statistics 2025-10-28 Zikai Li

We develop a unified theory of designs for controlled experiments that balance baseline covariates a priori (before treatment and before randomization) using the framework of minimax variance and a new method called kernel allocation. We…

Statistics Theory · Mathematics 2017-08-02 Nathan Kallus

Experimental design is crucial for inference where limitations in the data collection procedure are present due to cost or other restrictions. Optimal experimental designs determine parameters that in some appropriate sense make the data…

Machine Learning · Statistics 2016-03-11 Panagiotis Tsilifis , Roger G. Ghanem , Paris Hajali

The quantum pigeonhole effect (QPE) appears to contradict the classical pigeonhole principle by allowing three quantum particles distributed between two boxes to exhibit no pairwise coincidence. We show that this effect does not signal a…

Quantum Physics · Physics 2026-02-17 Yanlong Sun , Haiqing Wei , Jack W. Smith , Hongbin Wang

We study the question of how best to stratify units into matched pairs in online experiments, so that units within a pair receive opposite treatment. Past work by Bai, Romano, and Shaikh (2022) has demonstrated the asymptotic variance…

Methodology · Statistics 2025-05-26 Tim Morrison

The design of experiments involves a compromise between covariate balance and robustness. This paper provides a formalization of this trade-off and describes an experimental design that allows experimenters to navigate it. The design is…

Methodology · Statistics 2023-11-16 Christopher Harshaw , Fredrik Sävje , Daniel Spielman , Peng Zhang

Digital firms routinely run many online experiments on shared user populations. When product decisions are compositional, such as combinations of interface elements, flows, messages, or incentives, the number of feasible interventions grows…

Machine Learning · Statistics 2026-04-13 Xin Wen , Xi Chen , Will Wei Sun , Yichen Zhang

This article studies the benefits of using spatially randomized experimental designs which partition the experimental area into distinct, non-overlapping units with treatments assigned randomly. Such designs offer improved policy evaluation…

Statistics Theory · Mathematics 2025-11-18 Ying Yang , Chengchun Shi , Fang Yao , Shouyang Wang , Hongtu Zhu

Rerandomization enforces covariate balance across treatment groups in the design stage of experiments. Despite its intuitive appeal, its theoretical justification remains unsatisfying because its benefits of improving efficiency for…

Statistics Theory · Mathematics 2025-05-05 Xin Lu , Peng Ding

Computational models are powerful tools for understanding human cognition and behavior. They let us express our theories clearly and precisely, and offer predictions that can be subtle and often counter-intuitive. However, this same…

In this paper, we study the design and analysis of experiments conducted on a set of units over multiple time periods where the starting time of the treatment may vary by unit. The design problem involves selecting an initial treatment time…

Econometrics · Economics 2023-09-27 Ruoxuan Xiong , Susan Athey , Mohsen Bayati , Guido Imbens

Psychological interventions, especially those leveraging mobile and wireless technologies, often include multiple components that are delivered and adapted on multiple timescales (e.g., coaching sessions adapted monthly based on clinical…

This paper studies how to design two-wave experiments in the presence of spillovers for precise inference on treatment effects. We consider units connected through a single network, local dependence among individuals, and a general class of…

Econometrics · Economics 2025-11-25 Davide Viviano

Experimental design has emerged as a powerful approach for improving the sample efficiency of A/B testing, yet existing designs rely critically on correctly specified models. We study robust sequential experimental design under model…

Machine Learning · Statistics 2026-05-14 Qianglin Wen , Xiangkun Wu , Chengchun Shi , Ting Li , Niansheng Tang , Yingying Zhang , Hongtu Zhu

This paper describes PyOED, a highly extensible scientific package that enables developing and testing model-constrained optimal experimental design (OED) for inverse problems. Specifically, PyOED aims to be a comprehensive Python toolkit…

Mathematical Software · Computer Science 2023-12-20 Abhijit Chowdhary , Shady E. Ahmed , Ahmed Attia

Stochastic optimization is a widely used approach for optimization under uncertainty, where uncertain input parameters are modeled by random variables. Exact or approximation algorithms have been obtained for several fundamental problems in…

Machine Learning · Computer Science 2025-08-14 Arpit Agarwal , Rohan Ghuge , Viswanath Nagarajan , Zhengjia Zhuo

For paired comparison experiments involving competing options described by two-level attributes several different methods of constructing designs having block paired observations under the main effects model are presented. These designs are…

Methodology · Statistics 2019-10-16 Eric Nyarko

Online experiments %in which experimental units receive a sequence of treatments over time are frequently employed in many technological companies to evaluate the performance of a newly developed policy, product, or treatment relative to a…

Econometrics · Economics 2025-01-14 Ke Sun , Linglong Kong , Hongtu Zhu , Chengchun Shi

Within the framework of complex system design, it is often necessary to solve mixed variable optimization problems, in which the objective and constraint functions can depend simultaneously on continuous and discrete variables.…

Optimization and Control · Mathematics 2020-03-10 Julien Pelamatti , Loic Brevault , Mathieu Balesdent , El-Ghazali Talbi , Yannick Guerin

We consider the performance of the difference-in-means estimator in a two-arm randomized experiment under common experimental endpoints such as continuous (regression), incidence, proportion and survival. We examine performance under both…

Statistics Theory · Mathematics 2025-07-08 David Azriel , Abba M. Krieger , Adam Kapelner
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