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Biological systems are characterized by the ubiquitous roles of weak, that is, non-covalent molecular interactions, small, often very small, numbers of specific molecules per cell, and Brownian motion. These combine to produce stochastic…

Cell Behavior · Quantitative Biology 2023-04-27 Michael W. Klymkowsky

Chiral active matter is predicted to exhibit odd elasticity, with nontraditional elastic response arising from a combination of chirality, being out of equilibrium, and the presence of nonreciprocal interactions. One of the resulting…

Soft Condensed Matter · Physics 2025-11-10 Sang Hyun Choi , Zhi-Feng Huang , Nigel Goldenfeld

Nonlinear oscillations are commonly observed in complex systems far from equilibrium, such as living organisms. These oscillations are essential for sustaining vital processes, like neuronal firing, circadian rhythms, and heartbeats. In…

Statistical Mechanics · Physics 2026-04-15 Daiki Sekizawa , Sosuke Ito , Masafumi Oizumi

Traditionally, physical models of associative memory assume conditions of equilibrium. Here, we consider a prototypical oscillator model of associative memory and study how active noise sources that drive the system out of equilibrium, as…

Disordered Systems and Neural Networks · Physics 2023-07-26 Matthew Du , Agnish Kumar Behera , Suriyanarayanan Vaikuntanathan

This paper presents an algorithm for approximating certain types of dynamical systems given by a system of ordinary delay differential equations by a Boolean network model. Often Boolean models are much simpler to understand than complex…

Molecular Networks · Quantitative Biology 2011-05-10 Franziska Hinkelmann , Reinhard Laubenbacher

In this paper we study how to shape temporal pulses to switch a bistable system between its stable steady states. Our motivation for pulse-based control comes from applications in synthetic biology, where it is generally difficult to…

Optimization and Control · Mathematics 2015-10-05 Aivar Sootla , Diego Oyarzun , David Angeli , Guy-Bart Stan

A stochastic model of intracellular calcium oscillations is analytically studied. The governing master equation is expanded under the linear noise approximation and a closed prediction for the power spectrum of fluctuations analytically…

Statistical Mechanics · Physics 2013-07-15 Laura Cantini , Claudia Cianci , Duccio Fanelli , Emma Massi , Luigi Barletti

Hybrid multiscale modelling has emerged as a useful framework for modelling complex biological phenomena. However, when accounting for stochasticity in the internal dynamics of agents, these models frequently become computationally…

Quantitative Methods · Quantitative Biology 2021-05-11 Daria Stepanova , Helen M. Byrne , Philip K. Maini , Tomás Alarcón

It is well known that conservative mechanical systems exhibit local oscillatory behaviours due to their elastic and gravitational potentials, which completely characterise these periodic motions together with the inertial properties of the…

Optimization and Control · Mathematics 2023-06-26 Yannik Wotte , Sven Dummer , Nicolò Botteghi , Christoph Brune , Stefano Stramigioli , Federico Califano

Hair cells, the sensory receptors of the internal ear, subserve different functions in various receptor organs: they detect oscillatory stimuli in the auditory system, but transduce constant and step stimuli in the vestibular and…

Neurons and Cognition · Quantitative Biology 2017-03-29 Joshua D. Salvi , Daibhid O Maoileidigh , Brian A. Fabella , Melanie Tobin , A. J. Hudspeth

We quantify the effect of Gaussian white noise on fast--slow dynamical systems with one fast and two slow variables, which display mixed-mode oscillations owing to the presence of a folded-node singularity. The stochastic system can be…

Dynamical Systems · Mathematics 2015-03-06 Nils Berglund , Barbara Gentz , Christian Kuehn

We introduce the concept of self-tuned criticality as a general mechanism for signal detection in sensory systems. In the case of hearing, we argue that active amplification of faint sounds is provided by a dynamical system which is…

Biological Physics · Physics 2009-11-06 Sebastien Camalet , Thomas Duke , Frank Julicher , Jacques Prost

This work proposes a general framework for capturing noise-driven transitions in spatially extended non-equilibrium systems and explains the emergence of coherent patterns beyond the instability onset. The framework relies on stochastic…

Dynamical Systems · Mathematics 2024-12-16 Mickaël D. Chekroun , Honghu Liu , James C. McWilliams

We consider simple stochastic climate models, described by slowly time-dependent Langevin equations. We show that when the noise intensity is not too large, these systems can spend substantial amounts of time in metastable equilibrium,…

Atmospheric and Oceanic Physics · Physics 2007-05-23 Nils Berglund , Barbara Gentz

The dynamics of an ensemble of bistable elements under the influence of noise and with global time-delayed coupling is studied numerically by using a Langevin description and analytically by using 1) a Gaussian approximation and 2) a…

Statistical Mechanics · Physics 2009-11-10 Daniel Huber , Lev S. Tsimring

Non-equilibrium processes which convert chemical energy into mechanical motion enable the motility of organisms. Bundles of inextensible filaments driven by energy transduction of molecular motors form essential components of micron-scale…

Soft Condensed Matter · Physics 2013-06-13 Abhrajit Laskar , Rajeev Singh , Somdeb Ghose , Gayathri Jayaraman , P. B. Sunil Kumar , R. Adhikari

This work is devoted to investigating a compressible fluid system with low stratification, which is driven by fast acoustic waves and internal waves. The approximation using a soundproof model is justified. More precisely, the soundproof…

Analysis of PDEs · Mathematics 2022-08-24 Didier Bresch , Rupert Klein , Xin Liu

The distinct timescales of synaptic plasticity and neural activity dynamics play an important role in the brain's learning and memory systems. Activity-dependent plasticity reshapes neural circuit architecture, determining spontaneous and…

Neurons and Cognition · Quantitative Biology 2023-06-30 Heather L Cihak , Zachary P Kilpatrick

Nonlinear oscillators are a key modelling tool in many applications. The influence of annealed noise on nonlinear oscillators has been studied intensively. It can induce effects in nonlinear oscillators not present in the deterministic…

Chaotic Dynamics · Physics 2018-12-24 C. Kuehn

Economic and financial time series can feature locally explosive behavior when a bubble is formed. The economic or financial bubble, especially its dynamics, is an intriguing topic that has been attracting longstanding attention. To…

Statistics Theory · Mathematics 2025-01-29 Xuanling Yang , Dong Li , Ting Zhang
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