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Improving performance on complex tasks and enabling interpretable decision making in large language models (LLMs), especially for clinical applications, requires effective reasoning. Yet this remains challenging without supervised…

Computation and Language · Computer Science 2025-05-26 Che Liu , Haozhe Wang , Jiazhen Pan , Zhongwei Wan , Yong Dai , Fangzhen Lin , Wenjia Bai , Daniel Rueckert , Rossella Arcucci

The selection of appropriate medical imaging procedures is a critical and complex clinical decision, guided by extensive evidence-based standards such as the ACR Appropriateness Criteria (ACR-AC). However, the underutilization of these…

Quantitative Methods · Quantitative Biology 2025-10-07 Satrio Pambudi , Filippo Menolascina

Adverse drug reactions (ADRs) are a major barrier to safe and effective pharmacotherapy and increasingly reflect higher order interactions between drugs, genetic background, and clinical phenotypes. Existing graph based approaches usually…

Quantitative Methods · Quantitative Biology 2025-12-02 Ze Cai , Haotian Tang , Shuai Gao , Binbin Zhou , Junhan Zhao , Jun Wen

The process of electronic approach to writing and sending medical prescription promises to improve patient safety, health outcomes, maintaining patients privacy, promoting clinician acceptance and prescription security when compared with…

Computers and Society · Computer Science 2015-06-12 Adebayo Omotosho , Emuoyibofarhe Justice

Hypergraphs model higher-order relations that drive real-world decisions, from drug prescriptions to recommendations. A central structural signal in such data, beyond what pairwise relations can express, is interaction compositionality:…

Machine Learning · Computer Science 2026-05-19 Kyrie Zhao , Zehong Wang , Tianyi Ma , Fang Wu , Xiangru Tang , Pietro Lio , Sheng Wang , Yanfang Ye

Medical coding translates professionally written medical reports into standardized codes, which is an essential part of medical information systems and health insurance reimbursement. Manual coding by trained human coders is time-consuming…

Computation and Language · Computer Science 2021-09-27 Wei Sun , Shaoxiong Ji , Erik Cambria , Pekka Marttinen

It is crucial to provide compatible treatment schemes for a disease according to various symptoms at different stages. However, most classification methods might be ineffective in accurately classifying a disease that holds the…

Machine Learning · Computer Science 2019-11-26 Jianguo Chen , Kenli Li , Huigui Rong , Kashif Bilal , Nan Yang , Keqin Li

Recipe is a set of instructions that describes how to make food. It can help people from the preparation of ingredients, food cooking process, etc. to prepare the food, and increasingly in demand on the Web. To help users find the vast…

Multimedia · Computer Science 2023-10-25 Jialiang Shi , Takahiro Komamizu , Keisuke Doman , Haruya Kyutoku , Ichiro Ide

Adverse drug reactions (ADRs) induced from high-order drug-drug interactions (DDIs) due to polypharmacy represent a significant public health problem. In this paper, we formally formulate the to-avoid and safe (with respect to ADRs) drug…

Information Retrieval · Computer Science 2018-03-09 Wen-Hao Chiang , Li Shen , Lang Li , Xia Ning

Prediction of medical codes from clinical notes is both a practical and essential need for every healthcare delivery organization within current medical systems. Automating annotation will save significant time and excessive effort spent by…

Computation and Language · Computer Science 2021-07-23 Byung-Hak Kim , Varun Ganapathi

Objective: Retrieval-based Clinical Decision Support (ReCDS) can aid clinical workflow by providing relevant literature and similar patients for a given patient. However, the development of ReCDS systems has been severely obstructed by the…

Computation and Language · Computer Science 2023-12-21 Zhengyun Zhao , Qiao Jin , Fangyuan Chen , Tuorui Peng , Sheng Yu

Side effects of prescribed medications are a common occurrence. Electronic healthcare databases present the opportunity to identify new side effects efficiently but currently the methods are limited due to confounding (i.e. when an…

Databases · Computer Science 2016-11-17 Jenna M. Reps , Uwe Aickelin , Jiangang Ma , Yanchun Zhang

Medical coding is the task of assigning medical codes to clinical free-text documentation. Healthcare professionals manually assign such codes to track patient diagnoses and treatments. Automated medical coding can considerably alleviate…

Machine Learning · Computer Science 2023-04-24 Joakim Edin , Alexander Junge , Jakob D. Havtorn , Lasse Borgholt , Maria Maistro , Tuukka Ruotsalo , Lars Maaløe

Training medical image analysis models requires large amounts of expertly annotated data which is time-consuming and expensive to obtain. Images are often accompanied by free-text radiology reports which are a rich source of information. In…

Recommendation Systems (RS) are often used to address the issue of medical doctor referrals. However, these systems require access to patient feedback and medical records, which may not always be available in real-world scenarios. Our…

Machine Learning · Computer Science 2023-08-23 Filipa Valdeira , Stevo Racković , Valeria Danalachi , Qiwei Han , Cláudia Soares

Personalized cancer treatment requires a thorough understanding of complex interactions between drugs and cancer cell lines in varying genetic and molecular contexts. To address this, high-throughput screening has been used to generate…

Machine Learning · Computer Science 2023-07-03 Vishal Dey , Xia Ning

Reasoning-based large language models have excelled in mathematics and programming, yet their potential in knowledge-intensive medical question answering remains underexplored and insufficiently validated in clinical contexts. To bridge…

Computation and Language · Computer Science 2025-10-10 Yu Sun , Xingyu Qian , Weiwen Xu , Hao Zhang , Chenghao Xiao , Long Li , Deli Zhao , Wenbing Huang , Tingyang Xu , Qifeng Bai , Yu Rong

Introduction: This article is part of the Focus Theme of METHODS of Information in Medicine on "Managing Interoperability and Complexity in Health Systems". Background: The proliferation of archetypes as a means to represent information of…

Quantitative Methods · Quantitative Biology 2024-02-21 Idoia Berges , Jesús Bermúdez , Arantza Illarramendi

In this work, we propose Oph-Guid-RAG, a multimodal visual RAG system for ophthalmology clinical question answering and decision support. We treat each guideline page as an independent evidence unit and directly retrieve page images,…

Artificial Intelligence · Computer Science 2026-03-24 Shuying Chen , Sen Cui , Zhong Cao

The widespread use of the internet has led to an overwhelming amount of data, which has resulted in the problem of information overload. Recommender systems have emerged as a solution to this problem by providing personalized…

Information Retrieval · Computer Science 2024-08-15 Hui Fang , Xu Feng , Lu Qin , Zhu Sun