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Current clinical decision support systems (CDSSs) typically base their predictions on correlation, not causation. In recent years, causal machine learning (ML) has emerged as a promising way to improve decision-making with CDSSs by offering…

Human-Computer Interaction · Computer Science 2026-04-17 Domenique Zipperling , Lukas Schmidt , Benedikt Hahn , Niklas Kühl , Steven Kimbrough

In a changing climate, sustainable agriculture is essential for food security and environmental health. However, it is challenging to understand the complex interactions among its biophysical, social, and economic components. Predictive…

Safety cases, structured arguments that a system is acceptably safe, are becoming central to the governance of AI systems. Yet, traditional safety-case practices from aviation or nuclear engineering rely on well-specified system boundaries,…

Software Engineering · Computer Science 2026-03-09 Sung Une Lee , Liming Zhu , Md Shamsujjoha , Liming Dong , Qinghua Lu , Jieshan Chen , Lionel Briand

Machine learning (ML) pervades an increasing number of academic disciplines and industries. Its impact is profound, and several fields have been fundamentally altered by it, autonomy and computer vision for example; reliability engineering…

Machine Learning · Computer Science 2020-08-20 Zhaoyi Xu , Joseph Homer Saleh

Objective: The growing availability of large-scale observational clinical datasets and challenges in conducting randomized controlled trials have spurred enthusiasm in using causal machine learning (ML) for causal inference in observational…

We observed that safety arguments are prone to stay too abstract, e.g. solutions refer to large packages, argument strategies to complex reasoning steps, contexts and assumptions lack traceability. These issues can reduce the confidence we…

Software Engineering · Computer Science 2025-03-21 Mario Gleirscher , Carmen Carlan

Causal Machine Learning (CausalML) is an umbrella term for machine learning methods that formalize the data-generation process as a structural causal model (SCM). This perspective enables us to reason about the effects of changes to this…

Machine Learning · Computer Science 2026-05-28 Jean Kaddour , Aengus Lynch , Qi Liu , Matt J. Kusner , Ricardo Silva

Machine learning (ML) has recently created many new success stories. Hence, there is a strong motivation to use ML technology in software-intensive systems, including safety-critical systems. This raises the issue of safety verification of…

Software Engineering · Computer Science 2020-07-01 Hermann Kaindl , Stefan Kramer

This paper describes a method for creating compelling safety cases. The method seeks to help improve safety case practice in order to address the weaknesses identified in current practice, in particular confirmation bias, after-the-fact…

Software Engineering · Computer Science 2025-02-04 Richard Hawkins

Machine learning algorithms are increasingly influencing our decisions and interacting with us in all parts of our daily lives. Therefore, just like for power plants, highways, and myriad other engineered sociotechnical systems, we must…

Machine Learning · Statistics 2016-01-19 Kush R. Varshney

Causal machine learning (ML) offers flexible, data-driven methods for predicting treatment outcomes including efficacy and toxicity, thereby supporting the assessment and safety of drugs. A key benefit of causal ML is that it allows for…

The safety of automated driving systems must be justified by convincing arguments and supported by compelling evidence to persuade certification agencies, regulatory entities, and the general public to allow the systems on public roads.…

Software Engineering · Computer Science 2024-10-28 Jonas Krook , Yuvaraj Selvaraj , Wolfgang Ahrendt , Martin Fabian

Machine learning (ML) systems are rapidly increasing in size, are acquiring new capabilities, and are increasingly deployed in high-stakes settings. As with other powerful technologies, safety for ML should be a leading research priority.…

Machine Learning · Computer Science 2022-06-20 Dan Hendrycks , Nicholas Carlini , John Schulman , Jacob Steinhardt

The European Machinery Directive and related harmonized standards do consider that software is used to generate safety-relevant behavior of the machinery but do not consider all kinds of software. In particular, software based on machine…

Software Engineering · Computer Science 2022-08-18 Rasmus Adler , Michael Klaes

As Automated Driving Systems (ADS) technology advances, ensuring safety and public trust requires robust assurance frameworks, with safety cases emerging as a critical tool toward such a goal. This paper explores an approach to assess how a…

Software Engineering · Computer Science 2025-06-12 Scott Schnelle , Francesca Favaro , Laura Fraade-Blanar , David Wichner , Holland Broce , Justin Miranda

Dependability assurance of systems embedding machine learning(ML) components---so called learning-enabled systems (LESs)---is a key step for their use in safety-critical applications. In emerging standardization and guidance efforts, there…

Software Engineering · Computer Science 2023-01-11 Erfan Asaadi , Ewen Denney , Ganesh Pai

Machine learning (ML) models are used in many safety- and security-critical applications nowadays. It is therefore important to measure the security of a system that uses ML as a component. This paper focuses on the field of ML,…

Cryptography and Security · Computer Science 2024-06-21 Jan Schröder , Jakub Breier

The paper reviews methods that seek to draw causal inference from observational data and demonstrates how they can be applied to empirical problems in engineering research. It presents a framework for causal identification based on the…

Applications · Statistics 2022-11-28 Daniel J Graham

Despite the extent of recent advances in Machine Learning (ML) and Neural Networks, providing formal guarantees on the behavior of these systems is still an open problem, and a crucial requirement for their adoption in regulated or…

Machine Learning · Computer Science 2024-10-01 Matteo Francobaldi , Michele Lombardi

Context: Machine Learning (ML) has been at the heart of many innovations over the past years. However, including it in so-called 'safety-critical' systems such as automotive or aeronautic has proven to be very challenging, since the shift…