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The field of clinical natural language processing has been advanced significantly since the introduction of deep learning models. The self-supervised representation learning and the transfer learning paradigm became the methods of choice in…

Computation and Language · Computer Science 2020-04-27 Andrey Kormilitzin , Nemanja Vaci , Qiang Liu , Alejo Nevado-Holgado

Background: Widespread adoption of electronic health records (EHRs) has enabled secondary use of EHR data for clinical research and healthcare delivery. Natural language processing (NLP) techniques have shown promise in their capability to…

Information Retrieval · Computer Science 2021-06-15 Sijia Liu , Yanshan Wang , Andrew Wen , Liwei Wang , Na Hong , Feichen Shen , Steven Bedrick , William Hersh , Hongfang Liu

The objective of our work is to demonstrate the feasibility of utilizing deep learning models to extract safety signals related to the use of dietary supplements (DS) in clinical text. Two tasks were performed in this study. For the named…

Information Retrieval · Computer Science 2020-11-24 Yadan Fan , Sicheng Zhou , Yifan Li , Rui Zhang

Motivation: Unanticipated drug-drug interactions (DDIs) pose significant risks in polypharmacy, emphasizing the need for predictive methods. Recent advancements in computational techniques aim to address this challenge. Methods: We…

Machine Learning · Computer Science 2024-06-04 Katayoun Kobraei , Mehrdad Baradaran , Seyed Mohsen Sadeghi , Raziyeh Masumshah , Changiz Eslahchi

User-generated texts available on the web and social platforms are often long and semantically challenging, making them difficult to annotate. Obtaining human annotation becomes increasingly difficult as problem domains become more…

Computation and Language · Computer Science 2023-09-19 Joseph Gatto , Sarah M. Preum

Hypoglycemia is common and potentially dangerous among those treated for diabetes. Electronic health records (EHRs) are important resources for hypoglycemia surveillance. In this study, we report the development and evaluation of deep…

Computation and Language · Computer Science 2018-11-30 Yonghao Jin , Fei Li , Hong Yu

Adverse Drug Reactions (ADRs) are characterized within randomized clinical trials and postmarketing pharmacovigilance, but their molecular mechanism remains unknown in most cases. Aside from clinical trials, many elements of knowledge about…

Opioid related aberrant behaviors (ORABs) present novel risk factors for opioid overdose. This paper introduces a novel biomedical natural language processing benchmark dataset named ODD, for ORAB Detection Dataset. ODD is an…

Computation and Language · Computer Science 2024-03-26 Sunjae Kwon , Xun Wang , Weisong Liu , Emily Druhl , Minhee L. Sung , Joel I. Reisman , Wenjun Li , Robert D. Kerns , William Becker , Hong Yu

While word error rates of automatic speech recognition (ASR) systems have consistently fallen, natural language understanding (NLU) applications built on top of ASR systems still attribute significant numbers of failures to low-quality…

Audio and Speech Processing · Electrical Eng. & Systems 2024-01-05 David M. Chan , Shalini Ghosh , Hitesh Tulsiani , Ariya Rastrow , Björn Hoffmeister

Alzheimer's Disease (AD) is an irreversible neurodegenerative disease affecting 50 million people worldwide. Low-cost, accurate identification of key markers of AD is crucial for timely diagnosis and intervention. Language impairment is one…

Computation and Language · Computer Science 2025-05-27 Tingyu Mo , Jacqueline C. K. Lam , Victor O. K. Li , Lawrence Y. L. Cheung

Adverse drug events (ADEs) are a serious health problem that can be life-threatening. While a lot of studies have been performed on detect correlation between a drug and an AE, limited studies have been conducted on personalized ADE risk…

Machine Learning · Computer Science 2021-04-20 Jinhe Shi , Xiangyu Gao , Chenyu Ha , Yage Wang , Guodong Gao , Yi Chen

Scaling inference-time computation has substantially improved the reasoning capabilities of language models. However, existing methods have significant limitations: serialized chain-of-thought approaches generate overly long outputs,…

Artificial Intelligence · Computer Science 2025-08-19 Jiayi Pan , Xiuyu Li , Long Lian , Charlie Snell , Yifei Zhou , Adam Yala , Trevor Darrell , Kurt Keutzer , Alane Suhr

Combination pharmacotherapy offers substantial therapeutic advantages but also poses substantial risks of adverse drug reactions (ADRs). The accurate prediction of ADRs with interpretable computational methods is crucial for clinical safety…

Machine Learning · Computer Science 2026-03-17 Y. Cheung

Delirium is an acute decline or fluctuation in attention, awareness, or other cognitive function that can lead to serious adverse outcomes. Despite the severe outcomes, delirium is frequently unrecognized and uncoded in patients' electronic…

Drug repurposing identifies new therapeutic uses for existing drugs, reducing the time and costs compared to traditional de novo drug discovery. Most existing drug repurposing studies using real-world patient data often treat the entire…

Machine Learning · Computer Science 2024-12-31 Seungyeon Lee , Ruoqi Liu , Feixiong Cheng , Ping Zhang

In Biomedical Natural Language Processing (BioNLP) tasks, such as Relation Extraction, Named Entity Recognition, and Text Classification, the scarcity of high-quality data remains a significant challenge. This limitation poisons large…

Computation and Language · Computer Science 2025-04-01 Zhengyi Zhao , Shubo Zhang , Bin Liang , Binyang Li , Kam-Fai Wong

With the advent of artificial intelligence (AI), many researchers are attempting to extract structured information from document-level biomedical literature by fine-tuning large language models (LLMs). However, they face significant…

Neural and Evolutionary Computing · Computer Science 2026-02-26 Lei Zhao , Ling Kang , Quan Guo

Automatically extracting the relationships between chemicals and diseases is significantly important to various areas of biomedical research and health care. Biomedical experts have built many large-scale knowledge bases (KBs) to advance…

Computation and Language · Computer Science 2019-12-24 Huiwei Zhou , Yunlong Yang , Shixian Ning , Zhuang Liu , Chengkun Lang , Yingyu Lin , Degen Huang

Natural language inference (NLI), also known as Recognizing Textual Entailment (RTE), is an important aspect of natural language understanding. Most research now uses machine learning and deep learning to perform this task on specific…

Artificial Intelligence · Computer Science 2024-05-03 Xuyao Feng , Anthony Hunter

Side effects of prescribed medications are a common occurrence. Electronic healthcare databases present the opportunity to identify new side effects efficiently but currently the methods are limited due to confounding (i.e. when an…

Databases · Computer Science 2016-11-17 Jenna M. Reps , Uwe Aickelin , Jiangang Ma , Yanchun Zhang
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