English
Related papers

Related papers: Explainable Artificial Intelligence for Pharmacovi…

200 papers

The growing capabilities of AI models are leading to their wider use, including in safety-critical domains. Explainable AI (XAI) aims to make these models safer to use by making their inference process more transparent. However, current…

Feature attribution XAI algorithms enable their users to gain insight into the underlying patterns of large datasets through their feature importance calculation. Existing feature attribution algorithms treat all features in a dataset…

Artificial Intelligence · Computer Science 2022-03-25 Veera Raghava Reddy Kovvuri , Siyuan Liu , Monika Seisenberger , Berndt Müller , Xiuyi Fan

Explainable Artificial Intelligence (XAI) is increasingly rec ognized as essential for deploying machine learning systems in safety critical environments. In Automatic Target Recognition (ATR), where models operate on image, video, radar,…

Artificial Intelligence · Computer Science 2026-05-08 Vanessa Buhrmester , David Muench , Dimitri Bulatov , Michael Arens

Deep learning models are one of the security strategies, trained on extensive datasets, and play a critical role in detecting and responding to these threats by recognizing complex patterns in malicious code. However, the opaque nature of…

Cryptography and Security · Computer Science 2025-08-15 Richa Dasila , Vatsala Upadhyay , Samo Bobek , Abhishek Vaish

An increasing ubiquity of machine learning (ML) motivates research on algorithms to explain ML models and their predictions -- so-called eXplainable Artificial Intelligence (XAI). Despite many survey papers and discussions, the goals and…

Machine Learning · Computer Science 2024-07-16 Moritz Renftle , Holger Trittenbach , Michael Poznic , Reinhard Heil

In the present paper we present the potential of Explainable Artificial Intelligence methods for decision-support in medical image analysis scenarios. With three types of explainable methods applied to the same medical image data set our…

Artificial Intelligence · Computer Science 2021-05-20 Samanta Knapič , Avleen Malhi , Rohit Saluja , Kary Främling

ProfileXAI is a model- and domain-agnostic framework that couples post-hoc explainers (SHAP, LIME, Anchor) with retrieval - augmented LLMs to produce explanations for different types of users. The system indexes a multimodal knowledge base,…

The present research tackles the difficulty of predicting osteoporosis risk via machine learning (ML) approaches, emphasizing the use of explainable artificial intelligence (XAI) to improve model transparency. Osteoporosis is a significant…

Machine Learning · Computer Science 2025-10-03 Farhana Elias , Md Shihab Reza , Muhammad Zawad Mahmud , Samiha Islam , Shahran Rahman Alve

Explainable AI (XAI) is an increasingly important area of machine learning research, which aims to make black-box models transparent and interpretable. In this paper, we propose a novel approach to XAI that uses the so-called counterfactual…

Artificial Intelligence · Computer Science 2023-08-02 Bastian Pfeifer , Mateusz Krzyzinski , Hubert Baniecki , Anna Saranti , Andreas Holzinger , Przemyslaw Biecek

Explainable Artificial Intelligence (XAI) techniques hold significant potential for enhancing the causal discovery process, which is crucial for understanding complex systems in areas like healthcare, economics, and artificial intelligence.…

Machine Learning · Computer Science 2025-10-20 Jesus Renero , Idoia Ochoa , Roberto Maestre

With the increasing interest in deploying Artificial Intelligence in medicine, we previously introduced HAIM (Holistic AI in Medicine), a framework that fuses multimodal data to solve downstream clinical tasks. However, HAIM uses data in a…

Artificial Intelligence · Computer Science 2025-07-02 Periklis Petridis , Georgios Margaritis , Vasiliki Stoumpou , Dimitris Bertsimas

Drug repositioning holds great promise because it can reduce the time and cost of new drug development. While drug repositioning can omit various R&D processes, confirming pharmacological effects on biomolecules is essential for application…

Machine Learning · Computer Science 2022-12-29 Atsuko Takagi , Mayumi Kamada , Eri Hamatani , Ryosuke Kojima , Yasushi Okuno

Artificial intelligence (AI) is increasingly used to support prognosis in Alzheimer's disease (AD), but adoption remains limited due to a lack of transparency and interpretability, particularly for long-term predictions where uncertainty is…

Human-Computer Interaction · Computer Science 2026-02-03 Jonatan Reyes , Mina Massoumi , Anil Ufuk Batmaz , Marta Kersten-Oertel

Predictive Process Monitoring (PPM) has been integrated into process mining tools as a value-adding task. PPM provides useful predictions on the further execution of the running business processes. To this end, machine learning-based…

Machine Learning · Computer Science 2022-02-18 Ghada Elkhawaga , Mervat Abuelkheir , Manfred Reichert

The increasing complexity of AI systems has led to the growth of the field of Explainable Artificial Intelligence (XAI), which aims to provide explanations and justifications for the outputs of AI algorithms. While there is considerable…

Artificial Intelligence · Computer Science 2024-06-21 Maryam Hashemi , Ali Darejeh , Francisco Cruz

Machine learning is an essential tool for optimizing industrial quality control processes. However, the complexity of machine learning models often limits their practical applicability due to a lack of interpretability. Additionally, many…

Artificial Intelligence · Computer Science 2025-11-12 Georg Rottenwalter , Marcel Tilly , Victor Owolabi

Context: In recent years, leveraging machine learning (ML) techniques has become one of the main solutions to tackle many software engineering (SE) tasks, in research studies (ML4SE). This has been achieved by utilizing state-of-the-art…

Software Engineering · Computer Science 2023-02-14 Ahmad Haji Mohammadkhani , Nitin Sai Bommi , Mariem Daboussi , Onkar Sabnis , Chakkrit Tantithamthavorn , Hadi Hemmati

Black-box nature of Artificial Intelligence (AI) models do not allow users to comprehend and sometimes trust the output created by such model. In AI applications, where not only the results but also the decision paths to the results are…

Artificial Intelligence · Computer Science 2024-10-28 Ibrahim Kok , Feyza Yildirim Okay , Ozgecan Muyanli , Suat Ozdemir

Deep neural networks have become increasingly popular for analyzing ECG data because of their ability to accurately identify cardiac conditions and hidden clinical factors. However, the lack of transparency due to the black box nature of…

Signal Processing · Electrical Eng. & Systems 2024-07-03 Patrick Wagner , Temesgen Mehari , Wilhelm Haverkamp , Nils Strodthoff

Chemical toxicity prediction using machine learning is important in drug development to reduce repeated animal and human testing, thus saving cost and time. It is highly recommended that the predictions of computational toxicology models…

Quantitative Methods · Quantitative Biology 2020-09-28 Kar Wai Lim , Bhanushee Sharma , Payel Das , Vijil Chenthamarakshan , Jonathan S. Dordick