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In this paper, we describe the numerical reconstruction method for quantitative photoacoustic tomography (QPAT) based on the radiative transfer equation (RTE), which models light propagation more accurately than diffusion approximation…

Quantitative Methods · Quantitative Biology 2017-10-25 Chao Wang , Tie Zhou

Photoacoustic computed tomography (PACT) is a rapidly emerging bioimaging modality that seeks to reconstruct an estimate of the absorbed optical energy density within an object. Conventional PACT image reconstruction methods assume a…

Medical Physics · Physics 2016-11-18 Chao Huang , Kun Wang , Robert W. Schoonover , Lihong V. Wang , Mark A. Anastasio

3D photoacoustic tomography (3D-PAT) using high-frequency hemispherical transducers offers near-omnidirectional reception and enhanced sensitivity to the finer structural details encoded in the high-frequency components of the broadband…

Image and Video Processing · Electrical Eng. & Systems 2025-07-29 I Gede Eka Sulistyawan , Takuro Ishii , Riku Suzuki , Yoshifumi Saijo

In photoacoustic tomography (PAT), the computation of the initial pressure distribution within an object from its time-dependent boundary measurements over time is considered. This problem can be approached from two well-established points…

Numerical Analysis · Mathematics 2025-07-04 Jaakko Kultima , Ronny Ramlau , Teemu Sahlström , Tanja Tarvainen

Photoacoustic imaging (PAI), by combining high optical contrast with ultrasonic resolution, offers a promising noninvasive approach for dynamic monitoring of cerebral vasculature. However, transcranial PAI still faces significant challenges…

Ultrasound computed tomography techniques have the potential to provide clinicians with 3D, quantitative and high-resolution information of both soft and hard tissues such as the breast or the adult human brain. Their practical application…

Signal Processing · Electrical Eng. & Systems 2022-05-19 Carlos Cueto , Lluis Guasch , Javier Cudeiro , Oscar Calderon Agudo , Oscar Bates , George Strong , Meng-Xing Tang

We study the inverse source problem in photoacoustic tomography (PAT) for mixed data, which denote a weighted linear combination of the acoustic pressure and its normal derivative on an observation surface. We consider in particular the…

Analysis of PDEs · Mathematics 2022-07-06 Florian Dreier , Markus Haltmeier

Significance: Dynamic photoacoustic computed tomography (PACT) is a valuable technique for monitoring physiological processes. However, current dynamic PACT techniques are often limited to 2D spatial imaging. While volumetric PACT imagers…

Signal Processing · Electrical Eng. & Systems 2023-10-03 Refik M. Cam , Chao Wang , Weylan Thompson , Sergey A. Ermilov , Mark A. Anastasio , Umberto Villa

Ultrasonic phased array technology, while versatile, often requires complex computing resources and numerous amplifier components. We present a Manually Reconfigurable Phased Array that physically controls transducer position and phase,…

Applied Physics · Physics 2025-05-22 Soma Mochizuki , Yoichi Ochiai , Tatsuki Fushimi

Pediatric medical imaging presents unique challenges due to significant anatomical and developmental differences compared to adults. Direct application of segmentation models trained on adult data often yields suboptimal performance,…

Image and Video Processing · Electrical Eng. & Systems 2025-07-09 Tristan Kirscher , Sylvain Faisan , Xavier Coubez , Loris Barrier , Philippe Meyer

Accurate segmentation of anatomical structures in ultrasound (US) images, particularly small ones, is challenging due to noise and variability in imaging conditions (e.g., probe position, patient anatomy, tissue characteristics and…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 Danielle L. Ferreira , Ahana Gangopadhyay , Hsi-Ming Chang , Ravi Soni , Gopal Avinash

Photoacoustic computed tomography (PACT) is a promising imaging modality that combines the advantages of optical contrast with ultrasound detection. Utilizing ultrasound transducers with larger surface areas can improve detection…

This work is concerned with uncertainty quantification problems for image reconstructions in quantitative photoacoustic imaging (PAT), a recent hybrid imaging modality that utilizes the photoacoustic effect to achieve high-resolution…

Numerical Analysis · Mathematics 2018-12-10 Kui Ren , Sarah Vallélian

Quantitative photoacoustic tomography is an emerging imaging technique aimed at estimating the distribution of optical parameters inside tissues from photoacoustic images, which are formed by combining optical information and ultrasonic…

Numerical Analysis · Mathematics 2016-06-02 Antti Hannukainen , Nuutti Hyvönen , Helle Majander , Tanja Tarvainen

Optical coherence tomography (OCT) and photoacoustic tomography (PAT) are emerging non-invasive biological and medical imaging techniques. It is a recent trend in experimental science to design experiments that perform PAT and OCT imaging…

Analysis of PDEs · Mathematics 2016-04-19 Peter Elbau , Leonidas Mindrinos , Otmar Scherzer

Synthetic PET images are valuable for quantitative imaging workflow development, scalable virtual imaging trials, and deep learning model training, but conventional physics-based simulation approaches are computationally intensive, limited…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Suya Li , Kaushik Dutta , Debojyoti Pal , Jingqin Luo , Kooresh I. Shoghi

Photoacoustic imaging (PAI) is a promising emerging imaging modality that enables spatially resolved imaging of optical tissue properties up to several centimeters deep in tissue, creating the potential for numerous exciting clinical…

Medical Physics · Physics 2021-04-15 Janek Gröhl , Melanie Schellenberg , Kris Dreher , Lena Maier-Hein

We investigate resolution in photoacoustic tomography (PAT). Using Shannon theory, we investigate the theoretical resolution limit of sparse view PAT theoretically, and empirically demonstrate that all reconstruction methods used exceed…

Numerical Analysis · Mathematics 2023-10-17 Markus Haltmeier , Daniel Obmann , Karoline Felbermayer , Florian Hinterleitner , Peter Burgholzer

Photoacoustic computed tomography (PACT) is a proven technology for imaging hemodynamics in deep brain of small animal models. PACT is inherently compatible with ultrasound (US) imaging, providing complementary contrast mechanisms. While…

Instrumentation and Detectors · Physics 2023-07-28 Yuqi Tang , Zhijie Dong , Nanchao Wang , Angela del Aguila , Natalie Johnston , Tri Vu , Chenshuo Ma , Yirui Xu , Wei Yang , Pengfei Song , Junjie Yao

Photoacoustic computed tomography (PACT) is an emerging imaging modality that exploits optical contrast and ultrasonic detection principles to form images of the photoacoustically induced initial pressure distribution within tissue. The…

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