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Nitrogen-vacancy (NV) centers in diamond are a leading modality for magnetic sensing and imaging under ambient conditions. However, these sensors suffer from degraded performance due to paramagnetic impurities and regions of stress in the…

Quantum Physics · Physics 2024-04-22 Connor Roncaioli , Connor Hart , Ronald Walsworth , Donald P. Fahey

The detection of individual molecules and their dynamics has been a long-standing challenge in the field of nanotechnology. In this work, we present a method that utilizes a nitrogen vacancy (NV) center and a dangling-bond on the diamond…

Quantum Physics · Physics 2023-12-15 A. Biteri-Uribarren , P. Alsina-Bolívar , C. Munuera-Javaloy , R. Puebla , J. Casanova

A key challenge in cardiology is the non-invasive imaging of electric current propagation occurring in the cardiovascular system at an intra-cardiac scale. A promising approach for directly mapping the current dynamics is to monitor the…

Brain-wide recordings of large-scale networks of neurons now provide an unprecedented view into how the brain drives behavior. However, brain activity contains both information directly related to behavior as well as the potential for many…

Neurons and Cognition · Quantitative Biology 2026-05-06 Eva Yezerets , En Yang , Misha B. Ahrens , Adam S. Charles

Sensors that are able to detect and track single unlabelled biomolecules are an important tool both to understand biomolecular dynamics and interactions at nanoscale, and for medical diagnostics operating at their ultimate detection limits.…

Optics · Physics 2016-11-15 N. P. Mauranyapin , L. S. Madsen , M. A. Taylor , M. Waleed , W. P. Bowen

Magnetic sensing and imaging instruments are important tools in biological and material sciences. There is an increasing demand for attaining higher sensitivity and spatial resolution, with implementations using a single qubit offering…

Paramagnetic magnetic resonance, a powerful technique for characterizing and identifying chemical targets, is increasingly used for imaging; however, low spin polarization at room temperature and moderate magnetic fields poses challenges…

Mesoscale and Nanoscale Physics · Physics 2019-09-04 C. M. Purser , V. P. Bhallamudi , C. S. Wolfe , H. Yusuf , B. A. McCullian , C. Jayaprakash , M. E. Flatté , P. C. Hammel

Several centimeters below the skin lie multiple biomarkers, such as glucose, oxygenation, and blood flow. Monitoring these biomarkers regularly and in a non-invasive manner would enable early insight into metabolic status and vascular…

Medical Physics · Physics 2025-10-30 Talia Xu , Caitlin Smith , Charles Lo , Jami Shepherd , Gijs van Soest , Marco Zuniga

Color centers in diamond are promising candidates for quantum nanosensing applications. The efficient collection of the optical signal is the key to achieving high sensitivity and resolution, but it is limited by the collection optics.…

Optics · Physics 2020-09-07 Sumin Choi , Victor Leong , Gandhi Alagappan , Leonid Krivitsky

Interaction of electric fields with biological cells is indispensable for many physiological processes. Thermal electrical noise in the cellular environment has long been considered as the minimum threshold for detection of electrical…

Soft Condensed Matter · Physics 2026-02-24 Anand Mathew , Yashashree Kulkarni

Interfacing artificial functional materials and living neuronal tissues is at the forefront of bio-nano-technology. Attempts have been so far based onto microscale processing of metals and inorganic semiconductors as electrodes or…

Droplet microlasers, as promising tools for biophotonics and biomedical sciences, have witnessed rapid advances due to their flexible reconfigurability, high sensitivity to stimuli, and label-free biosensing ability. However, designing…

Deep learning methods for classifying medical images have demonstrated impressive accuracy in a wide range of tasks but often these models are hard to interpret, limiting their applicability in clinical practice. In this work we introduce a…

Image and Video Processing · Electrical Eng. & Systems 2019-08-13 James R. Clough , Ilkay Oksuz , Esther Puyol-Anton , Bram Ruijsink , Andrew P. King , Julia A. Schnabel

Biomonitoring wearable sensors based on two-dimensional nanomaterials have lately elicited keen research interest and potential for a new range of flexible nanoelectronic devices. Practical nanomaterial-based devices suited for real-world…

Diamond has long been identified as a potential host material for laser applications. This potential arises due to its exceptional thermal properties, ultra-wide bandgap, and color centers which promise gain across the visible spectrum.…

Photoacoustic imaging has emerged as a powerful, non-invasive modality for various biomedical applications. Conventional photoacoustic systems require contact-based ultrasound detection and expensive and bulky high-power lasers for the…

Applied Physics · Physics 2025-01-06 Emiel Dieussaert , Roel Baets , Hilde Jans , Xavier Rottenberg , Yanlu Li

Relaxometry schemes employing nitrogen-vacancy (NV) centers in diamonds are essential in biology and physics to detect a reduction of the color centers' characteristic spin relaxation ($T_1$) time caused by, e.g., paramagnetic molecules in…

Quantum Physics · Physics 2024-11-05 Isabel Cardoso Barbosa , Jonas Gutsche , Artur Widera

Micro- and nanothermometry enable precise temperature monitoring and control at the micro- and nanoscale, and have become essential diagnostic tools in applications ranging from high-power microelectronics to biosensing and nanomedicine.…

Materials Science · Physics 2025-10-28 Md Shakhawath Hossain , Dylan G. Stone , G. Landry , Xiaoxue Xu , Carlo Bradac , Toan Trong Tran

We present a new magnetometry method integrating an ensemble of nitrogen-vacancy (NV) centers in a single-crystal diamond with an extended dynamic range for monitoring the fast changing magnetic-field. The NV-center spin resonance frequency…

Probing electrical and magnetic properties in aqueous environments remains a frontier challenge in nanoscale sensing. Our inability to do so with quantitative accuracy imposes severe limitations, for example, on our understanding of the…