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The quantitative detection, segmentation, and characterization of glomeruli from high-resolution whole slide imaging (WSI) play essential roles in the computer-assisted diagnosis and scientific research in digital renal pathology.…

Computer Vision and Pattern Recognition · Computer Science 2022-06-02 Tianyuan Yao , Yuzhe Lu , Jun Long , Aadarsh Jha , Zheyu Zhu , Zuhayr Asad , Haichun Yang , Agnes B. Fogo , Yuankai Huo

Due to the large size and lack of fine-grained annotation, Whole Slide Images (WSIs) analysis is commonly approached as a Multiple Instance Learning (MIL) problem. However, previous studies only learn from training data, posing a stark…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Weiqin Zhao , Ziyu Guo , Yinshuang Fan , Yuming Jiang , Maximus Yeung , Lequan Yu

Accurately predicting and detecting interstitial lung disease (ILD) patterns given any computed tomography (CT) slice without any pre-processing prerequisites, such as manually delineated regions of interest (ROIs), is a clinically…

Computer Vision and Pattern Recognition · Computer Science 2017-01-23 Mingchen Gao , Ziyue Xu , Le Lu , Adam P. Harrison , Ronald M. Summers , Daniel J. Mollura

Introduction: Multiple Sclerosis (MS) is a chronic disease that affects millions of people across the globe. MS can critically affect different organs of the central nervous system such as the eyes, the spinal cord, and the brain.…

Image and Video Processing · Electrical Eng. & Systems 2023-02-21 Atif Shah , Maged S. Al-Shaibani , Moataz Ahmad , Reem Bunyan

This paper presents an autoencoder-based neural network architecture to compress histopathological images while retaining the denser and more meaningful representation of the original images. Current research into improving compression…

Image and Video Processing · Electrical Eng. & Systems 2023-05-15 Agnes Barsi , Suvendu Chandan Nayak , Sasmita Parida , Raj Mani Shukla

Cortical lesions (CLs) have emerged as valuable biomarkers in multiple sclerosis (MS), offering high diagnostic specificity and prognostic relevance. However, their routine clinical integration remains limited due to subtle magnetic…

Multiple sclerosis is an inflammatory autoimmune demyelinating disease that is characterized by lesions in the central nervous system. Typically, magnetic resonance imaging (MRI) is used for tracking disease progression. Automatic image…

Image and Video Processing · Electrical Eng. & Systems 2020-08-06 Nils Gessert , Julia Krüger , Roland Opfer , Ann-Christin Ostwaldt , Praveena Manogaran , Hagen H. Kitzler , Sven Schippling , Alexander Schlaefer

Diabetic Retinopathy (DR) refers to a barrier that takes place in diabetes mellitus damaging the blood vessel network present in the retina. This may endanger the subjects' vision if they have diabetes. It can take some time to perform a DR…

Computer Vision and Pattern Recognition · Computer Science 2023-05-02 V. Banupriya , S. Anusuya

Kidney volume is greatly affected in several renal diseases. Precise and automatic segmentation of the kidney can help determine kidney size and evaluate renal function. Fully convolutional neural networks have been used to segment organs…

Image and Video Processing · Electrical Eng. & Systems 2020-09-02 Omid Bazgir , Kai Barck , Richard A. D. Carano , Robby M. Weimer , Luke Xie

While microscopic analysis of histopathological slides is generally considered as the gold standard method for performing cancer diagnosis and grading, the current method for analysis is extremely time consuming and labour intensive as it…

Computer Vision and Pattern Recognition · Computer Science 2018-06-25 Rene Bidart , Alexander Wong

Histopathology image analysis can be considered as a Multiple instance learning (MIL) problem, where the whole slide histopathology image (WSI) is regarded as a bag of instances (i.e, patches) and the task is to predict a single class label…

Computer Vision and Pattern Recognition · Computer Science 2019-06-28 Meng Li , Lin Wu , Arnold Wiliem , Kun Zhao , Teng Zhang , Brian C. Lovell

Diagnostic pathology, which is the basis and gold standard of cancer diagnosis, provides essential information on the prognosis of the disease and vital evidence for clinical treatment. Tumor region detection, subtype and grade…

Image and Video Processing · Electrical Eng. & Systems 2021-10-27 Jialun Wu , Haichuan Zhang , Zeyu Gao , Xinrui Bao , Tieliang Gong , Chunbao Wang , Chen Li

Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Wei-Wen Hsu , Yongfang Wu , Chang Hao , Yu-Ling Hou , Xiang Gao , Yun Shao , Xueli Zhang , Tao He , Yanhong Tai

Fine-grained glomerular subtyping is central to kidney biopsy interpretation, but clinically valuable labels are scarce and difficult to obtain. Existing computational pathology approaches instead tend to evaluate coarse diseased…

For diagnosing melanoma, hematoxylin and eosin (H&E) stained tissue slides remains the gold standard. These images contain quantitative information in different magnifications. In the present study, we investigated whether deep…

Tissues and Organs · Quantitative Biology 2019-04-15 Peizhen Xie , Ke Zuo , Yu Zhang , Fangfang Li , Mingzhu Yin , Kai Lu

The emergence of foundation models in computational pathology has transformed histopathological image analysis, with whole slide imaging (WSI) diagnosis being a core application. Traditionally, weakly supervised fine-tuning via multiple…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Jiawen Li , Jiali Hu , Qiehe Sun , Renao Yan , Minxi Ouyang , Tian Guan , Anjia Han , Chao He , Yonghong He

In this paper, we propose a novel interpretation method tailored to histological Whole Slide Image (WSI) processing. A Deep Neural Network (DNN), inspired by Bag-of-Features models is equipped with a Multiple Instance Learning (MIL) branch…

Computer Vision and Pattern Recognition · Computer Science 2019-04-17 Magdalini Paschali , Muhammad Ferjad Naeem , Walter Simson , Katja Steiger , Martin Mollenhauer , Nassir Navab

Large medical image data sets with high dimensionality require substantial amount of computation time for data creation and data processing. This paper presents a novel generalized method that finds optimal image-based feature sets that…

Computer Vision and Pattern Recognition · Computer Science 2016-10-25 Sohini Roychowdhury

Crop diseases present a significant barrier to agricultural productivity and global food security, especially in large-scale farming where early identification is often delayed or inaccurate. This research introduces a Convolutional Neural…

Computer Vision and Pattern Recognition · Computer Science 2025-07-15 Sourish Suri , Yifei Shao

Diabetic retinopathy (DR) is the most common form of diabetic eye disease. Retinopathy can affect all diabetic patients and becomes particularly dangerous, increasing the risk of blindness, if it is left untreated. The success rate of its…

Computer Vision and Pattern Recognition · Computer Science 2019-02-11 Oindrila Saha , Rachana Sathish , Debdoot Sheet
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