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The segmentation of kidney layer structures, including cortex, outer stripe, inner stripe, and inner medulla within human kidney whole slide images (WSI) plays an essential role in automated image analysis in renal pathology. However, the…

Image and Video Processing · Electrical Eng. & Systems 2023-09-07 Muhao Liu , Chenyang Qi , Shunxing Bao , Quan Liu , Ruining Deng , Yu Wang , Shilin Zhao , Haichun Yang , Yuankai Huo

Automatic detection of lymphocyte in H&E images is a necessary first step in lots of tissue image analysis algorithms. An accurate and robust automated lymphocyte detection approach is of great importance in both computer science and…

Computer Vision and Pattern Recognition · Computer Science 2016-12-13 Jianxu Chen , Chukka Srinivas

Stain variability is a pervasive source of distribution shift and potential shortcut learning in renal pathology AI. We ask whether lupus nephritis glomerular lesion classifiers exploit stain as a shortcut, and how to mitigate such bias…

Computer Vision and Pattern Recognition · Computer Science 2026-04-13 Mohammad Daouk , Jan Ulrich Becker , Neeraja Kambham , Anthony Chang , Hien Van Nguyen , Chandra Mohan

Acute lymphoblastic leukemia (ALL) severity is determined by the presence and ratios of blast cells (abnormal white blood cells) in both bone marrow and peripheral blood. Manual diagnosis of this disease is a tedious and time-consuming…

Computer Vision and Pattern Recognition · Computer Science 2024-08-13 Amir Masoud Rahmani , Parisa Khoshvaght , Hamid Alinejad-Rokny , Samira Sadeghi , Parvaneh Asghari , Zohre Arabi , Mehdi Hosseinzadeh

In all developing and developed countries in the world, skin diseases are becoming a very frequent health problem for the humans of all age groups. Skin problems affect mental health, develop addiction to alcohol and drugs and sometimes…

Computer Vision and Pattern Recognition · Computer Science 2020-04-09 Arnab Banerjee , Nibaran Das , Mita Nasipuri

We propose a new method for cancer subtype classification from histopathological images, which can automatically detect tumor-specific features in a given whole slide image (WSI). The cancer subtype should be classified by referring to a…

Computer Vision and Pattern Recognition · Computer Science 2020-04-03 Noriaki Hashimoto , Daisuke Fukushima , Ryoichi Koga , Yusuke Takagi , Kaho Ko , Kei Kohno , Masato Nakaguro , Shigeo Nakamura , Hidekata Hontani , Ichiro Takeuchi

Renal cell carcinoma (RCC) is the most common renal cancer in adults. The histopathologic classification of RCC is essential for diagnosis, prognosis, and management of patients. Reorganization and classification of complex histologic…

Image and Video Processing · Electrical Eng. & Systems 2020-11-02 Mengdan Zhu , Bing Ren , Ryland Richards , Matthew Suriawinata , Naofumi Tomita , Saeed Hassanpour

Accurate classification of focal liver lesions is crucial for diagnosis and treatment in hepatology. However, traditional supervised deep learning models depend on large-scale annotated datasets, which are often limited in medical imaging.…

Computer Vision and Pattern Recognition · Computer Science 2025-05-07 Song Jian , Hu Yuchang , Wang Hui , Chen Yen-Wei

Whole slide imaging (WSI) refers to the digitization of a tissue specimen which enables pathologists to explore high-resolution images on a monitor rather than through a microscope. The formation of tissue folds occur during tissue…

Image and Video Processing · Electrical Eng. & Systems 2019-03-19 Morteza Babaie , H. R. Tizhoosh

Examining blood microscopic images for leukemia is necessary when expensive equipment for flow cytometry is unavailable. Automated systems can ease the burden on medical experts for performing this examination and may be especially helpful…

Computer Vision and Pattern Recognition · Computer Science 2020-04-02 Jonas Prellberg , Oliver Kramer

Segmentation of microvascular structures, such as arterioles, venules, and capillaries, from human kidney whole slide images (WSI) has become a focal point in renal pathology. Current manual segmentation techniques are time-consuming and…

Image and Video Processing · Electrical Eng. & Systems 2023-08-14 Franklin Hu , Ruining Deng , Shunxing Bao , Haichun Yang , Yuankai Huo

Objective: This article presents an automatic image processing framework to extract quantitative high-level information describing the micro-environment of glomeruli in consecutive whole slide images (WSIs) processed with different staining…

Computer Vision and Pattern Recognition · Computer Science 2021-05-04 Odyssee Merveille , Thomas Lampert , Jessica Schmitz , Germain Forestier , Friedrich Feuerhake , Cédric Wemmert

The motivation of this work is the use of non-invasive and low cost techniques to obtain a faster and more accurate diagnosis of systemic sclerosis (SSc), rheumatic, autoimmune, chronic and rare disease. The technique in question is Near…

Graves' disease is a common condition that is diagnosed clinically by determining the smoothness of the thyroid texture and its morphology in ultrasound images. Currently, the most widely used approach for the automated diagnosis of Graves'…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Su-Xi Yu , Jing-Yuan He , Yi Wang , Yu-Jiao Cai , Jun Yang , Bo Lin , Wei-Bin Yang , Jian Ruan

Comprehensive semantic segmentation on renal pathological images is challenging due to the heterogeneous scales of the objects. For example, on a whole slide image (WSI), the cross-sectional areas of glomeruli can be 64 times larger than…

Image and Video Processing · Electrical Eng. & Systems 2023-01-20 Ruining Deng , Quan Liu , Can Cui , Tianyuan Yao , Jun Long , Zuhayr Asad , R. Michael Womick , Zheyu Zhu , Agnes B. Fogo , Shilin Zhao , Haichun Yang , Yuankai Huo

Histopathology slides are routinely marked by pathologists using permanent ink markers that should not be removed as they form part of the medical record. Often tumour regions are marked up for the purpose of highlighting features or other…

Computer Vision and Pattern Recognition · Computer Science 2019-05-14 Sharib Ali , Nasullah Khalid Alham , Clare Verrill , Jens Rittscher

Glomerulosclerosis, interstitial fibrosis, and tubular atrophy (IFTA) are histologic indicators of irrecoverable kidney injury. In standard clinical practice, the renal pathologist visually assesses, under the microscope, the percentage of…

Tissues and Organs · Quantitative Biology 2021-06-23 Brandon Ginley , Kuang-Yu Jen , Avi Rosenberg , Felicia Yen , Sanjay Jain , Agnes Fogo , Pinaki Sarder

Vision-language models (VLMs) have shown considerable potential in digital pathology, yet their effectiveness remains limited for fine-grained, disease-specific classification tasks such as distinguishing between glomerular subtypes. The…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Zhenhao Guo , Rachit Saluja , Tianyuan Yao , Quan Liu , Yuankai Huo , Benjamin Liechty , David J. Pisapia , Kenji Ikemura , Mert R. Sabuncu , Yihe Yang , Ruining Deng

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

With the development of medical imaging technology and machine learning, computer-assisted diagnosis which can provide impressive reference to pathologists, attracts extensive research interests. The exponential growth of medical images and…

Computer Vision and Pattern Recognition · Computer Science 2020-10-08 Xiao Kang , Xingbo Liu , Xiushan Nie , Yilong Yin