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Individual-based model (IBM) has been used to simulate and to design control strategies for dynamic systems that are subject to stochasticity and heterogeneity, such as infectious diseases. In the IBM, an individual is represented by a set…

Populations and Evolution · Quantitative Biology 2019-02-11 E. G. Nepomuceno , D. F. Resende , M. J. Lacerda

We develop a general dynamical model as a framework for possible causal interpretation. We first state a criterion of local independence in terms of measurability of processes involved in the Doob-Meyer decomposition of stochastic…

Statistics Theory · Mathematics 2007-10-25 Daniel Commenges , Anne Gegout-Petit

We consider a spatially-heterogeneous generalization of a well-established model for the dynamics of the Human Immunodeficiency Virus-type 1 (HIV) within a susceptible host. The model consists of a nonlinear system of three coupled…

Analysis of PDEs · Mathematics 2016-04-18 Stephen Pankavich , Christian Parkinson

Hepatitis type B is one of the most common infectious disease worldwide that can pose severe threats to human health up to the point that may contribute to severe liver damage or cancer. Over the past two decades a large number of dynamic…

Quantitative Methods · Quantitative Biology 2020-04-22 SeyedMehdi Abtahi , Mojtaba Sharifi

This technical report describes a dynamic causal model of the spread of coronavirus through a population. The model is based upon ensemble or population dynamics that generate outcomes, like new cases and deaths over time. The purpose of…

This study presents an improved mathematical model for Hepatitis B Virus (HBV) transmission dynamics by investigating autonomous and nonautonomous cases. The novel model incorporates the effects of medical treatment, allowing for a more…

Dynamical Systems · Mathematics 2025-05-15 Abdallah Alsammani

Infectious diseases are caused by pathogenic microorganisms and can spread through different ways. Mathematical models and computational simulation have been used extensively to investigate the transmission and spread of infectious…

In this paper we describe a framework for model-based diagnosis of dynamic systems, which extends previous work in this field by using and expressing temporal uncertainty in the form of qualitative interval relations a la Allen. Based on a…

Artificial Intelligence · Computer Science 2013-02-28 Wolfgang Nejdl , Johann Gamper

Mathematical models of glucose, insulin, and pancreatic $\beta$-cell mass dynamics are essential for understanding the physiological basis of type 2 diabetes. This paper investigates the Topp model's discrete-time dynamics to represent…

Dynamical Systems · Mathematics 2024-05-02 Z. S. Boxonov , U. A. Rozikov

In this paper, we first propose a diffusive pathogen infection model with general incidence rate which incorporates cell-to-cell transmission. By applying the theory of monotone dynamical systems, we prove that the model admits the global…

Analysis of PDEs · Mathematics 2026-02-24 Shohel Ahmed

The majority of research on epidemics relies on models which are formulated in continuous-time. However, real-world epidemic data is gathered and processed in a digital manner, which is more accurately described by discrete-time epidemic…

Optimization and Control · Mathematics 2021-07-23 Bastian Prasse , Piet Van Mieghem

The aims of this work is to analyse of the global stability of the extended model of hepatitis C virus(HCV) infection with cellular proliferation, spontaneous cure and hepatocyte homeostasis. We first give general information about…

Dynamical Systems · Mathematics 2019-05-08 Alexis Nangue , Cyprien Fokoue , Raoue Poumeni

Mathematical modeling of biological systems is crucial to effectively and efficiently developing treatments for medical conditions that plague humanity. Often, systems of ordinary differential equations are a traditional tool used to…

Classical Analysis and ODEs · Mathematics 2015-09-01 Eric Jones , Peter Roemer , Mrinal Raghupathi , Stephen Pankavich

There has been interest in the interactions between infectious disease dynamics and behaviour for most of the history of mathematical epidemiology. This has included consideration of which mathematical models best capture each phenomenon,…

Populations and Evolution · Quantitative Biology 2025-12-09 Matthew Ryan , Roslyn I. Hickson , Edward M. Hill , Thomas House , Valerie Isham , Dongni Zhang , Mick G. Roberts

In this review, we recall the concepts of Identifiability and Observability of dynamical systems, and analyse them in the framework of Mathematical Epidemiology. We show that, even for simple and well known models of the literature, these…

Dynamical Systems · Mathematics 2023-05-23 Nik Cunniffe , Frédéric Hamelin , Abderrahman Iggidr , Alain Rapaport , Gauthier Sallet

In this manuscript we consider an age structured epidemic system modelling the dynamics of transmission of immunizing disease like Hepatitis B virus. Our model takes into account age as well as two classes of infected individuals (chronic…

Analysis of PDEs · Mathematics 2016-05-17 Yannick Tchaptchie Kouakep

We investigate an epidemic model based on Bailey's continuous differential system. In the continuous time domain, we extend the classical model to time-dependent coefficients and present an alternative solution method to Gleissner's…

Classical Analysis and ODEs · Mathematics 2019-01-01 Martin Bohner , Sabrina Streipert , Delfim F. M. Torres

Although modeling studies are focused on the control of SIR-based systems describing epidemic data sets (particularly the COVID-19), few of them present a formal dynamic characterization in terms of equilibrium sets and stability. Such…

Optimization and Control · Mathematics 2021-06-03 A. H. González , A. L. Anderson , A. Ferramosca , E. A. Hernandez-Vargas

The aim of this paper is to present an, admittedly somewhat subjective, bird's eye view of the mathematical theory concerning the spread of an infectious disease in a susceptible host population with static structure, culminating in a…

Populations and Evolution · Quantitative Biology 2025-08-06 Odo Diekmann , Hisashi Inaba , Horst R. Thieme

In order to model an epidemic, different approaches can be adopted. Mainly, the deterministic approach and the stochastic one. Recently, a large amount of literature has been published using the two approaches. The aim of this paper is to…

Populations and Evolution · Quantitative Biology 2023-01-30 Mohamed Mehdaoui