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Modern deep neural networks have a large number of parameters, making them very hard to train. We propose DSD, a dense-sparse-dense training flow, for regularizing deep neural networks and achieving better optimization performance. In the…

Computer Vision and Pattern Recognition · Computer Science 2017-02-23 Song Han , Jeff Pool , Sharan Narang , Huizi Mao , Enhao Gong , Shijian Tang , Erich Elsen , Peter Vajda , Manohar Paluri , John Tran , Bryan Catanzaro , William J. Dally

Personalized medicine has gained much popularity recently as a way of providing better healthcare by tailoring treatments to suit individuals. Our research, motivated by the UK INTERVAL blood donation trial, focuses on estimating the…

Methodology · Statistics 2023-02-24 Yuejia Xu , Angela M. Wood , David J. Roberts , Brian D. M. Tom

Precision medicine aims to tailor therapeutic decisions to individual patient characteristics. This objective is commonly formalized through dynamic treatment regimes, which use statistical and machine learning methods to derive sequential…

Machine Learning · Statistics 2026-03-23 Sophia Yazzourh , Erica E. M. Moodie

The vision for precision medicine is to use individual patient characteristics to inform a personalized treatment plan that leads to the best healthcare possible for each patient. Mobile technologies have an important role to play in this…

To promote precision medicine, individualized treatment regimes (ITRs) are crucial for optimizing the expected clinical outcome based on patient-specific characteristics. However, existing ITR research has primarily focused on scenarios…

Methodology · Statistics 2024-02-20 Chang Wang , Lu Wang

In precision medicine, Dynamic Treatment Regimes (DTRs) are treatment protocols that adapt over time in response to a patient's observed characteristics. A DTR is a set of decision functions that takes an individual patient's information as…

Methodology · Statistics 2022-03-17 Cong Jiang , Michael Wallace , Mary Thompson

In precision medicine, one of the most important problems is estimating the optimal individualized treatment rules (ITR), which typically involves recommending treatment decisions based on fully observed individual characteristics of…

Methodology · Statistics 2025-10-15 Yue Zhang , Shanshan Luo , Zhi Geng , Yangbo He

Optimizing a deep neural network is a fundamental task in computer vision, yet direct training methods often suffer from over-fitting. Teacher-student optimization aims at providing complementary cues from a model trained previously, but…

Computer Vision and Pattern Recognition · Computer Science 2018-12-04 Chenglin Yang , Lingxi Xie , Chi Su , Alan L. Yuille

Estimates of individual treatment effects from networked observational data are attracting increasing attention these days. One major challenge in network scenarios is the violation of the stable unit treatment value assumption (SUTVA),…

Machine Learning · Computer Science 2024-01-26 Ziyu Zhao , Yuqi Bai , Kun Kuang , Ruoxuan Xiong , Fei Wu

The covariate shift is a challenging problem in supervised learning that results from the discrepancy between the training and test distributions. An effective approach which recently drew a considerable attention in the research community…

Machine Learning · Computer Science 2013-11-27 Yun-Qian Miao , Ahmed K. Farahat , Mohamed S. Kamel

Dynamic treatment regimes (DTR) are a statistical paradigm in precision medicine which aim to optimize patient outcomes by individualizing treatments. At its simplest, a DTR may require only a single decision to be made; this special case…

Applications · Statistics 2021-09-06 Larry Dong , Erica E. M. Moodie , Laura Villain , Rodolphe Thiébaut

The current learning process of deep learning, regardless of any deep neural network (DNN) architecture and/or learning algorithm used, is essentially a single resolution training. We explore multiresolution learning and show that…

Machine Learning · Computer Science 2023-09-29 Hongyan Zhou , Yao Liang

Power distribution networks are approaching their voltage stability boundaries due to the severe voltage violations and the inadequate reactive power reserves caused by the increasing renewable generations and dynamic loads. In the broad…

Optimization and Control · Mathematics 2022-08-18 Wanjun Huang , Changhong Zhao

Learning-to-defer is a framework to automatically defer decision-making to a human expert when ML-based decisions are deemed unreliable. Existing learning-to-defer frameworks are not designed for sequential settings. That is, they defer at…

Machine Learning · Computer Science 2022-12-06 Shalmali Joshi , Sonali Parbhoo , Finale Doshi-Velez

The optimal dynamic treatment rule (ODTR) framework offers an approach for understanding which kinds of patients respond best to specific treatments -- in other words, treatment effect heterogeneity. Recently, there has been a proliferation…

An individualized treatment rule (ITR) tailors treatments to a patient's specific characteristics. However, randomized controlled trials (RCTs) are often underpowered to detect the treatment effect heterogeneity needed for reliable ITR…

Methodology · Statistics 2026-04-14 Yuan Bian , Donglin Zeng , Hyun-Joon Yang , Leanne M. Williams , Yuanjia Wang

Medical treatments tailored to a patient's baseline characteristics hold the potential of improving patient outcomes while reducing negative side effects. Learning individualized treatment rules (ITRs) often requires aggregation of multiple…

Machine Learning · Statistics 2022-12-15 Jay Jojo Cheng , Jared D. Huling , Guanhua Chen

Distantly-Supervised Named Entity Recognition (DS-NER) is widely used in real-world scenarios. It can effectively alleviate the burden of annotation by matching entities in existing knowledge bases with snippets in the text but suffer from…

Computation and Language · Computer Science 2025-07-04 Shuzheng Si , Helan Hu , Haozhe Zhao , Shuang Zeng , Kaikai An , Zefan Cai , Baobao Chang

Foundation models in healthcare have largely adopted self supervised pretraining objectives inherited from natural language processing and computer vision, emphasizing reconstruction and large scale representation learning prior to…

Machine Learning · Computer Science 2026-03-24 Yang Zhang , Li Fan , Samuel Lawrence , Shi Li

Machine learning can help personalized decision support by learning models to predict individual treatment effects (ITE). This work studies the reliability of prediction-based decision-making in a task of deciding which action $a$ to take…

Machine Learning · Statistics 2019-06-07 Iiris Sundin , Peter Schulam , Eero Siivola , Aki Vehtari , Suchi Saria , Samuel Kaski