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Background SAMtools and BCFtools are widely used programs for processing and analysing high-throughput sequencing data. Findings The first version appeared online twelve years ago and has been maintained and further developed ever since,…

There are numerous approaches to building analysis applications across the high-energy physics community. Among them are Python-based, or at least Python-driven, analysis workflows. We aim to ease the adoption of a Python-based analysis…

Computational Physics · Physics 2018-04-25 David Lange

The Herschel Interactive Processing Environment (HIPE) was developed by the European Space Agency (ESA) in collaboration with NASA and the Herschel Instrument Control Centres to provide the astronomical community a complete environment to…

Graphics · Computer Science 2012-07-18 Pasquale Panuzzo , Jinjing Li , Emmanuel Caux

High throughput sequencing (HTS) continues to expand our understanding of microbial communities, despite insufficient sequencing depths to detect all rare taxa. These low abundance taxa are not accounted for in existing methods for…

Applications · Statistics 2016-05-10 Amy Willis , John Bunge , Thea Whitman

As gene expression measurement technology is shifting from microarrays to sequencing, the statistical tools available for their analysis must be adapted since RNA-seq data are measured as counts. Recently, it has been proposed to tackle the…

Applications · Statistics 2022-11-10 Denis Agniel , Boris P Hejblum

Existing Python libraries and tools lack the ability to efficiently compute statistical test results for large datasets in the presence of missing values. This presents an issue as soon as constraints on runtime and memory availability…

Mathematical Software · Computer Science 2025-05-02 Fabian Woller , Lis Arend , Christian Fuchsberger , Markus List , David B. Blumenthal

Difficulty replicating baselines, high computational costs, and required domain expertise create persistent barriers to clinical AI research. To address these challenges, we introduce PyHealth 2.0, an enhanced clinical deep learning toolkit…

Helix is an open-source, extensible, Python-based software framework to facilitate reproducible and interpretable machine learning workflows for tabular data. It addresses the growing need for transparent experimental data analytics…

This paper was prepared by the HEP Software Foundation (HSF) PyHEP Working Group as input to the second phase of the LHCC review of High-Luminosity LHC (HL-LHC) computing, which took place in November, 2021. It describes the adoption of…

Data Analysis, Statistics and Probability · Physics 2022-02-09 Jim Pivarski , Eduardo Rodrigues , Kevin Pedro , Oksana Shadura , Benjamin Krikler , Graeme A. Stewart

This is the manual for the version 2 of HackAnalysis, a powerful, lightweight, versatile and, most importantly, hackable, recasting tool. New features in this version include: compressed event format storage for ultra-fast development;…

High Energy Physics - Phenomenology · Physics 2024-06-17 Mark D. Goodsell

HyperNetX (HNX) is an open source Python library for the analysis and visualization of complex network data modeled as hypergraphs. Initially released in 2019, HNX facilitates exploratory data analysis of complex networks using algebraic…

Mathematical Software · Computer Science 2023-10-19 Brenda Praggastis , Sinan Aksoy , Dustin Arendt , Mark Bonicillo , Cliff Joslyn , Emilie Purvine , Madelyn Shapiro , Ji Young Yun

High-throughput $ab$ $initio$ calculations are the indispensable parts of data-driven discovery of new materials with desirable properties, as reflected in the establishment of several online material databases. The accumulation of…

Computational Physics · Physics 2024-07-30 Niraj K. Nepal , Paul C. Canfield , Lin-Lin Wang

We introduce fairseq S2T, a fairseq extension for speech-to-text (S2T) modeling tasks such as end-to-end speech recognition and speech-to-text translation. It follows fairseq's careful design for scalability and extensibility. We provide…

Computation and Language · Computer Science 2022-06-15 Changhan Wang , Yun Tang , Xutai Ma , Anne Wu , Sravya Popuri , Dmytro Okhonko , Juan Pino

Motivation: Quality control of genomic data is an essential but complicated multi-step procedure, often requiring separate installation and expert familiarity with a combination of disparate bioinformatics tools. Results: To provide an…

Genomics · Quantitative Biology 2021-05-06 Christina Vasilopoulou , Benjamin Wingfield , Andrew P. Morris , William Duddy

This paper introduces Sparklen, a statistical learning toolkit for Hawkes processes in Python, designed to bring together efficiency and ease of use. The purpose of this package is to provide the Python community with a complete suite of…

Methodology · Statistics 2025-03-31 Romain Edmond Lacoste

Computational complexity is a key limitation of genomic analyses. Thus, over the last 30 years, researchers have proposed numerous fast heuristic methods that provide computational relief. Comparing genomic sequences is one of the most…

The analysis of experimental results with Python often requires writing many code scripts which all need access to the same set of functions. In a common field of research, this set will be nearly the same for many users. The qspec Python…

Computational Physics · Physics 2025-03-18 Patrick Müller , Wilfried Nörtershäuser

Semi-supervised classification leverages both labeled and unlabeled data to improve predictive performance, but existing software support remains fragmented across methods, learning settings, and data modalities. We introduce ModSSC, an…

Machine Learning · Computer Science 2026-02-17 Melvin Barbaux , Samia Boukir

This paper presents fairseq S^2, a fairseq extension for speech synthesis. We implement a number of autoregressive (AR) and non-AR text-to-speech models, and their multi-speaker variants. To enable training speech synthesis models with less…

Audio and Speech Processing · Electrical Eng. & Systems 2021-09-16 Changhan Wang , Wei-Ning Hsu , Yossi Adi , Adam Polyak , Ann Lee , Peng-Jen Chen , Jiatao Gu , Juan Pino

We consider the correction of errors from nucleotide sequences produced by next-generation targeted amplicon sequencing. The next-generation sequencing (NGS) platforms can provide a great deal of sequencing data thanks to their high…

Genomics · Quantitative Biology 2017-07-05 Byunghan Lee , Taesup Moon , Sungroh Yoon , Tsachy Weissman