High throughput sequencing (HTS) continues to expand our understanding of microbial communities, despite insufficient sequencing depths to detect all rare taxa. These low abundance taxa are not accounted for in existing methods for detecting changes in species richness. We address this with a new hierarchical model that permits rigorous testing for both heterogeneity and biodiversity changes, and simultaneously improves Type I & II error rates compared to existing methods.
@article{arxiv.1605.02082,
title = {Improved detection of changes in species richness in high-diversity microbial communities},
author = {Amy Willis and John Bunge and Thea Whitman},
journal= {arXiv preprint arXiv:1605.02082},
year = {2016}
}
Comments
arXiv admin note: text overlap with arXiv:1506.05710