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Analysis of genomics data is central to nearly all areas of modern biology. Despite significant progress in artificial intelligence (AI) and computational methods, these technologies require significant human oversight to generate novel and…

A monitor and control framework for quantum-key-distribution (QKD) networks equipped with switching capabilities was developed. On the one hand, this framework provides real-time visibility into operational metrics. Specifically, it…

The task of understanding and interpreting the complex information encoded within genomic sequences remains a grand challenge in biological research and clinical applications. In this context, recent advancements in large language model…

Genomics · Quantitative Biology 2024-09-25 Qihang Zhao , Chi Zhang , Weixiong Zhang

DNA is a promising medium for digital information storage for its exceptional density and durability. While prior studies advanced coding theory, workflow design, and simulation tools, challenges such as synthesis costs, sequencing errors,…

Emerging Technologies · Computer Science 2025-10-06 Rakesh Thakur , Lavanya Singh , Yashika , Manomay Bundawala , Aruna Kumar

There is an increasing need in our society to achieve faster advances in Science to tackle urgent problems, such as climate changes, environmental hazards, sustainable energy systems, pandemics, among others. In certain domains like…

Artificial Intelligence (AI) incorporating genetic and medical information have been applied in disease risk prediction, unveiling disease mechanism, and advancing therapeutics. However, AI training relies on highly sensitive and private…

While often assumed a gold standard, effective human evaluation of text generation remains an important, open area for research. We revisit this problem with a focus on producing consistent evaluations that are reproducible -- over time and…

Computation and Language · Computer Science 2022-11-02 Daniel Khashabi , Gabriel Stanovsky , Jonathan Bragg , Nicholas Lourie , Jungo Kasai , Yejin Choi , Noah A. Smith , Daniel S. Weld

Similar to natural language models, pre-trained genome language models are proposed to capture the underlying intricacies within genomes with unsupervised sequence modeling. They have become essential tools for researchers and practitioners…

Genomics · Quantitative Biology 2024-06-04 Siyuan Li , Zedong Wang , Zicheng Liu , Di Wu , Cheng Tan , Jiangbin Zheng , Yufei Huang , Stan Z. Li

The lack of high-quality data for content-grounded generation tasks has been identified as a major obstacle to advancing these tasks. To address this gap, we propose Genie, a novel method for automatically generating high-quality…

Computation and Language · Computer Science 2024-01-26 Asaf Yehudai , Boaz Carmeli , Yosi Mass , Ofir Arviv , Nathaniel Mills , Assaf Toledo , Eyal Shnarch , Leshem Choshen

Advances in genome sequencing technologies generate massive amounts of sequence data that are increasingly analyzed and shared through public repositories. On-demand infrastructure services on cloud computing platforms enable the processing…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-03-20 Junseok Park , Eduardo A. Maury , Changhoon Oh , Donghoon Shin , Danielle Denisko , Eunjung Alice Lee

Gene finding is the task of identifying the locations of coding sequences within the vast amount of genetic code contained in the genome. With an ever increasing quantity of raw genome sequences, gene finding is an important avenue towards…

Genomics · Quantitative Biology 2025-05-07 Frederikke I. Marin , Dennis Pultz , Wouter Boomsma

We describe the first DNA-based storage architecture that enables random access to data blocks and rewriting of information stored at arbitrary locations within the blocks. The newly developed architecture overcomes drawbacks of existing…

Information Theory · Computer Science 2015-05-12 S. M. Hossein Tabatabaei Yazdi , Yongbo Yuan , Jian Ma , Huimin Zhao , Olgica Milenkovic

Cancer is a complex disease driven by genomic alterations, and tumor sequencing is becoming a mainstay of clinical care for cancer patients. The emergence of multi-institution sequencing data presents a powerful resource for learning…

Genomics · Quantitative Biology 2024-10-31 Yuan Chen , Ronglai Shen , Xiwen Feng , Katherine Panageas

Gene expression profiling provides profound insights into molecular mechanisms, but its time-consuming and costly nature often presents significant challenges. In contrast, whole-slide hematoxylin and eosin (H&E) stained histological images…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Ying Xiong , Linjing Liu , Yufei Cui , Shangyu Wu , Xue Liu , Antoni B. Chan , Chun Jason Xue

Data is the most powerful decision-making tool at our disposal. However, despite the exponentially growing volumes of data generated in the world, putting it to effective use still presents many challenges. Relevant data seems to be never…

Databases · Computer Science 2021-11-12 Sergii Mikhtoniuk , Ozge Nilay Yalcin

The cost of DNA sequencing has resulted in a surge of genetic data being utilised to improve scientific research, clinical procedures, and healthcare delivery in recent years. Since the human genome can uniquely identify an individual, this…

Cryptography and Security · Computer Science 2022-02-11 Sara Jafarbeiki , Raj Gaire , Amin Sakzad , Shabnam Kasra Kermanshahi , Ron Steinfeld

We present a framework for the unification and standardization of quantum network protocols, making their realization easier and expanding their use cases to a broader range of communities interested in quantum technologies. Our framework…

Deep neural networks (DNNs) have been ubiquitously applied in many applications, and accelerators are emerged as an enabler to support the fast and efficient inference tasks of these applications. However, to achieve high model coverage…

Machine Learning · Computer Science 2021-05-10 Zhi Chen , Cody Hao Yu , Trevor Morris , Jorn Tuyls , Yi-Hsiang Lai , Jared Roesch , Elliott Delaye , Vin Sharma , Yida Wang

Quantum effects are mainly used for the determination of molecular shapes in molecular biology, but quantum information theory may be a more useful tool to understand the physics of life. Organic molecules and quantum circuits/protocols can…

Quantum Physics · Physics 2011-04-01 Onur Pusuluk , Cemsinan Deliduman

DNA sequencing is revolutionising the field of medicine. DNA sequencers, the machines which perform DNA sequencing, have evolved from the size of a fridge to that of a mobile phone over the last two decades. The cost of sequencing a human…

Genomics · Quantitative Biology 2021-01-14 Hasindu Gamaarachchi