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Trustworthy interpretation of deep learning models is critical for neuroimaging applications, yet commonly used Explainable AI (XAI) methods lack rigorous validation, risking misinterpretation. We performed the first large-scale, systematic…

Machine Learning · Computer Science 2025-08-07 Nys Tjade Siegel , James H. Cole , Mohamad Habes , Stefan Haufe , Kerstin Ritter , Marc-André Schulz

Explainable AI (XAI) methods focus on explaining what a neural network has learned - in other words, identifying the features that are the most influential to the prediction. In this paper, we call them "distinguishing features". However,…

Computer Vision and Pattern Recognition · Computer Science 2021-04-19 Kaili Wang , Jose Oramas , Tinne Tuytelaars

As deep learning models gain attraction in medical data, ensuring transparent and trustworthy decision-making is essential. In skin cancer diagnosis, while advancements in lesion detection and classification have improved accuracy, the…

Computer Vision and Pattern Recognition · Computer Science 2025-01-14 Sadia Kamal , Tim Oates

Deep Learning (DL) models processing images to recognize the health state of large infrastructure components can exhibit biases and rely on non-causal shortcuts. eXplainable Artificial Intelligence (XAI) can address these issues but…

Computer Vision and Pattern Recognition · Computer Science 2025-03-20 Giovanni Floreale , Piero Baraldi , Enrico Zio , Olga Fink

Explainable AI (XAI) methods provide explanations of AI models, but our understanding of how they compare with human explanations remains limited. In image classification, we found that humans adopted more explorative attention strategies…

Human-Computer Interaction · Computer Science 2023-04-11 Ruoxi Qi , Yueyuan Zheng , Yi Yang , Caleb Chen Cao , Janet H. Hsiao

The growing adoption of artificial intelligence in healthcare has raised concerns about the transparency and trustworthiness of AI-driven medical diagnosis systems. Many existing models operate as black boxes, limiting clinicians' ability…

Human-Computer Interaction · Computer Science 2026-04-21 Altynbek Seitenov , Ainur Nurzhanova , Azhar Bekbussinova , Yerassyl Bolatkan

Industrial Cyber-Physical Systems (CPS) are sensitive infrastructure from both safety and economics perspectives, making their reliability critically important. Machine Learning (ML), specifically deep learning, is increasingly integrated…

Machine Learning · Computer Science 2026-04-09 Annemarie Jutte , Uraz Odyurt

Skin lesions are an increasingly significant medical concern, varying widely in severity from benign to cancerous. Accurate diagnosis is essential for ensuring timely and appropriate treatment. This study examines the implementation of deep…

Computer Vision and Pattern Recognition · Computer Science 2024-09-09 Xiaoyi Liu , Zhou Yu , Lianghao Tan , Yafeng Yan , Ge Shi

The adoption of intelligent systems creates opportunities as well as challenges for medical work. On the positive side, intelligent systems have the potential to compute complex data from patients and generate automated diagnosis…

Human-Computer Interaction · Computer Science 2019-02-19 Yao Xie , Ge Gao , Xiang 'Anthony' Chen

We examine progress in the use of AI for detecting skin lesions, with particular emphasis on the erythema migrans rash of acute Lyme disease, and other lesions, such as those from conditions like herpes zoster (shingles), tinea corporis,…

Image and Video Processing · Electrical Eng. & Systems 2020-10-12 Philippe M. Burlina , William Paul , Phil A. Mathew , Neil J. Joshi , Alison W. Rebman , John N. Aucott

Skin cancer detection is challenging since different types of skin lesions share high similarities. This paper proposes a computer-based deep learning approach that will accurately identify different kinds of skin lesions. Deep learning…

Computer Vision and Pattern Recognition · Computer Science 2023-03-15 Mst Shapna Akter , Hossain Shahriar , Sweta Sneha , Alfredo Cuzzocrea

Deep learning models have recently demonstrated remarkable results in a variety of tasks, which is why they are being increasingly applied in high-stake domains, such as industry, medicine, and finance. Considering that automatic…

Machine Learning · Computer Science 2021-08-19 Ilija Šimić , Vedran Sabol , Eduardo Veas

The field of "explainable artificial intelligence" (XAI) seemingly addresses the desire that decisions of machine learning systems should be human-understandable. However, in its current state, XAI itself needs scrutiny. Popular methods…

Machine Learning · Computer Science 2026-04-09 Stefan Haufe , Rick Wilming , Benedict Clark , Rustam Zhumagambetov , Ahcène Boubekki , Jörg Martin , Danny Panknin

Skin lesion datasets consist predominantly of normal samples with only a small percentage of abnormal ones, giving rise to the class imbalance problem. Also, skin lesion images are largely similar in overall appearance owing to the low…

Image and Video Processing · Electrical Eng. & Systems 2020-07-29 Hasib Zunair , A. Ben Hamza

This study explores the integration of multiple Explainable AI (XAI) techniques to enhance the interpretability of deep learning models for brain tumour detection. A custom Convolutional Neural Network (CNN) was developed and trained on the…

Artificial Intelligence · Computer Science 2026-02-06 Patrick McGonagle , William Farrelly , Kevin Curran

Explainability plays a crucial role in providing a more comprehensive understanding of deep learning models' behaviour. This allows for thorough validation of the model's performance, ensuring that its decisions are based on relevant visual…

Machine Learning · Computer Science 2023-06-16 E. Zhixuan Zeng , Hayden Gunraj , Sheldon Fernandez , Alexander Wong

Nowadays Artificial Intelligence (AI) has become a fundamental component of healthcare applications, both clinical and remote, but the best performing AI systems are often too complex to be self-explaining. Explainable AI (XAI) techniques…

Machine Learning · Computer Science 2022-09-15 Flavio Di Martino , Franca Delmastro

Recent advances in deep learning and on-device inference could transform routine screening for skin cancers. Along with the anticipated benefits of this technology, potential dangers arise from unforeseen and inherent biases. A significant…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Ko Watanabe , Stanislav Frolov , Aya Hassan , David Dembinsky , Adriano Lucieri , Andreas Dengel

Black-box nature of Artificial Intelligence (AI) models do not allow users to comprehend and sometimes trust the output created by such model. In AI applications, where not only the results but also the decision paths to the results are…

Artificial Intelligence · Computer Science 2024-10-28 Ibrahim Kok , Feyza Yildirim Okay , Ozgecan Muyanli , Suat Ozdemir

The rising global prevalence of skin conditions, some of which can escalate to life-threatening stages if not timely diagnosed and treated, presents a significant healthcare challenge. This issue is particularly acute in remote areas where…

Computer Vision and Pattern Recognition · Computer Science 2024-02-19 Mahapara Khurshid , Mayank Vatsa , Richa Singh