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Spikes are the currency in central nervous systems for information transmission and processing. They are also believed to play an essential role in low-power consumption of the biological systems, whose efficiency attracts increasing…

Neural and Evolutionary Computing · Computer Science 2020-05-05 Qiang Yu , Shenglan Li , Huajin Tang , Longbiao Wang , Jianwu Dang , Kay Chen Tan

Spikes in the membrane electrical potentials of neurons play a major role in the functioning of nervous systems of animals. Obtaining the spikes from different neurons has been a challenging problem for decades. Several schemes have been…

Quantitative Methods · Quantitative Biology 2016-02-11 Anupam Mitra , Anagh Pathak , Kaushik Majumdar

Reliable spike detection and sorting, the process of assigning each detected spike to its originating neuron, is an essential step in the analysis of extracellular electrical recordings from neurons. The volume and complexity of the data…

Neurons and Cognition · Quantitative Biology 2018-09-05 Matthias H. Hennig , Cole Hurwitz , Martino Sorbaro

We present an algorithm to identify individual neural spikes observed on high-density multi-electrode arrays (MEAs). Our method can distinguish large numbers of distinct neural units, even when spikes overlap, and accounts for intrinsic…

Neurons and Cognition · Quantitative Biology 2013-08-01 Jason S. Prentice , Jan Homann , Kristina D. Simmons , Gašper Tkačik , Vijay Balasubramanian , Philip C. Nelson

Recent advancements in miniaturized fluorescence microscopy have made it possible to investigate neuronal responses to external stimuli in awake behaving animals through the analysis of intra-cellular calcium signals. An on-going challenge…

Applications · Statistics 2022-01-28 Laura D'Angelo , Antonio Canale , Zhaoxia Yu , Michele Guindani

Patchwork learning arises as a new and challenging data collection paradigm where both samples and features are observed in fragmented subsets. Due to technological limits, measurement expense, or multimodal data integration, such patchwork…

Methodology · Statistics 2024-06-21 Lili Zheng , Andersen Chang , Genevera I. Allen

Developing electrophysiological recordings of brain neuronal activity and their analysis provide a basis for exploring the structure of brain function and nervous system investigation. The recorded signals are typically a combination of…

Neurons and Cognition · Quantitative Biology 2019-11-01 Sahar Hojjatinia , Constantino M. Lagoa

In the last decade, there have been major advances in clusterless decoding algorithms for neural data analysis. These algorithms use the theory of marked point processes to describe the joint activity of many neurons simultaneously, without…

Neurons and Cognition · Quantitative Biology 2025-12-09 Azar Ghahari , Uri T. Eden

Spike sorting plays an irreplaceable role in understanding brain codes. Traditional spike sorting technologies perform feature extraction and clustering separately after spikes are well detected. However, it may often cause many additional…

Signal Processing · Electrical Eng. & Systems 2020-11-23 Libo Huang , Lu Gan , Bingo Wing-Kuen Ling

Estimating neuron location from extracellular recordings is essential for developing advanced brain-machine interfaces. Accurate neuron localization improves spike sorting, which involves detecting action potentials and assigning them to…

Neurons and Cognition · Quantitative Biology 2025-08-20 Hao Zhao , Xinhe Zhang , Arnau Marin-Llobet , Xinyi Lin , Jia Liu

We formulate a novel technique for the detection of functional clusters in discrete event data. The advantage of this algorithm is that no prior knowledge of the number of functional groups is needed, as our procedure progressively combines…

Neurons and Cognition · Quantitative Biology 2015-05-13 S. Feldt , J. Waddell , V. L. Hetrick , J. D. Berke , M. Zochowski

Background: Current neuronal monitoring techniques, such as calcium imaging and multi-electrode arrays, enable recordings of spiking activity from hundreds of neurons simultaneously. Of primary importance in systems neuroscience is the…

Neurons and Cognition · Quantitative Biology 2014-11-11 Yazan N. Billeh , Michael T. Schaub , Costas A. Anastassiou , Mauricio Barahona , Christof Koch

A Magnetoencephalography (MEG) time-series recording consists of multi-channel signals collected by superconducting sensors, with each signal's intensity reflecting magnetic field changes over time at the sensor location. Automating…

Signal Processing · Electrical Eng. & Systems 2025-01-22 Hanyang Dong , Shurong Sheng , Xiongfei Wang , Jiahong Gao , Yi Sun , Wanli Yang , Kuntao Xiao , Pengfei Teng , Guoming Luan , Zhao Lv

Spike-based neuromorphic hardware promises to reduce the energy consumption of image classification and other deep learning applications, particularly on mobile phones or other edge devices. However, direct training of deep spiking neural…

Neural and Evolutionary Computing · Computer Science 2021-01-27 Christoph Stöckl , Wolfgang Maass

DBSCAN is an algorithm that performs clustering in the presence of noise. In this paper, we provide two constructions that allow DBSCAN to be implemented neuromorphically, using spiking neural networks. The first construction is termed…

Neural and Evolutionary Computing · Computer Science 2024-09-24 Charles P. Rizzo , James S. Plank

Active dendrites are the basis for biologically plausible neural networks possessing many desirable features of the biological brain including flexibility, dynamic adaptability, and energy efficiency. A formulation for active dendrites…

Neural and Evolutionary Computing · Computer Science 2025-06-17 James E. Smith

With advances in neural recording techniques, neuroscientists are now able to record the spiking activity of many hundreds of neurons simultaneously, and new statistical methods are needed to understand the structure of this large-scale…

Neurons and Cognition · Quantitative Biology 2023-03-03 Ganchao Wei , Ian H. Stevenson , Xiaojing Wang

Modern neural recording techniques allow neuroscientists to obtain spiking activity of multiple neurons from different brain regions over long time periods, which requires new statistical methods to be developed for understanding structure…

Applications · Statistics 2023-12-29 Ganchao Wei

Information processing in the brain is conducted by a concerted action of multiple neural populations. Gaining insights in the organization and dynamics of such populations can best be studied with broadband intracranial recordings of…

Spike sorting algorithms are used to separate extracellular recordings of neuronal populations into single-unit spike activities. The development of customized hardware implementing spike sorting algorithms is burgeoning. However, there is…

Machine Learning · Computer Science 2025-01-30 Tim Zhang , Corey Lammie , Mostafa Rahimi Azghadi , Amirali Amirsoleimani , Majid Ahmadi , Roman Genov
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