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High-throughput electron microscopy allows recording of lar- ge stacks of neural tissue with sufficient resolution to extract the wiring diagram of the underlying neural network. Current efforts to automate this process focus mainly on the…

Computer Vision and Pattern Recognition · Computer Science 2018-07-17 Julia Buhmann , Renate Krause , Rodrigo Ceballos Lentini , Nils Eckstein , Matthew Cook , Srinivas Turaga , Jan Funke

We tackle a quantification of synchrony in a large ensemble of interacting neurons from the observation of spiking events. In a simulation study, we efficiently infer the synchrony level in a neuronal population from a point process…

Neurons and Cognition · Quantitative Biology 2025-03-25 Arkady Pikovsky , Michael Rosenblum

This paper deals with the problem of extracting the activity of individual neurons from multi-electrode recordings. Important aspects of this work are: 1) the sorting is done in two stages - a statistical model of the spikes from different…

Data Analysis, Statistics and Probability · Physics 2007-05-23 Dima Rinberg , William Bialek , Hanan Davidowitz , Naftali Tishby

Clustering large, mixed data is a central problem in data mining. Many approaches adopt the idea of k-means, and hence are sensitive to initialisation, detect only spherical clusters, and require a priori the unknown number of clusters. We…

Machine Learning · Statistics 2020-11-13 Joshua Tobin , Mimi Zhang

Spiking neuronal networks are usually simulated with three main simulation schemes: the classical time-driven and event-driven schemes, and the more recent hybrid scheme. All three schemes evolve the state of a neuron through a series of…

Neurons and Cognition · Quantitative Biology 2018-01-24 Jeyashree Krishnan , PierGianLuca Porta Mana , Moritz Helias , Markus Diesmann , Edoardo Di Napoli

Spike-sorting techniques attempt to classify a series of noisy electrical waveforms according to the identity of the neurons that generated them. Existing techniques perform this classification ignoring several properties of actual neurons…

Quantitative Methods · Quantitative Biology 2007-05-23 Christophe Pouzat

Human brain neuron activities are incredibly significant nowadays. Neuronal behavior is assessed by analyzing signal data such as electroencephalography (EEG), which can offer scientists valuable information about diseases and…

With the sensor scaling of next-generation Brain-Machine Interface (BMI) systems, the massive A/D conversion and analog multiplexing at the neural frontend poses a challenge in terms of power and data rates for wireless and implantable…

Signal Processing · Electrical Eng. & Systems 2024-05-15 Ye Ke , Arindam Basu

Spike sorting is a fundamental preprocessing step for many neuroscience studies which rely on the analysis of spike trains. In this paper, we present two unsupervised spike sorting algorithms based on discriminative subspace learning. The…

Computer Vision and Pattern Recognition · Computer Science 2014-08-25 Mohammad Reza Keshtkaran , Zhi Yang

Since the advent of mobile robots, obstacle detection has been a topic of great interest. It has also been a subject of study in neuroscience, where flying insects and bats could be considered two of the most interesting cases in terms of…

In electrophysiology, microelectrodes are the primary source for recording neural data of single neurons (single unit activity). These microelectrodes can be implanted individually, or in the form of microelectrodes arrays, consisting of…

Animal brains exhibit remarkable efficiency in perception and action, while being robust to both external and internal perturbations. The means by which brains accomplish this remains, for now, poorly understood, hindering our understanding…

Neurons and Cognition · Quantitative Biology 2026-03-11 André Urbano , Pablo Lanillos , Sander Keemink

Biological systems use neural circuits to integrate input information and produce outputs. Synaptic convergence, where multiple neurons converge their inputs onto a single downstream neuron, is common in natural neural circuits. However,…

Mesoscale and Nanoscale Physics · Physics 2026-02-04 Wendy Otieno , Alex Gabbitas , Debi Pattnaik , Pavel Borisov , Sergey Savel'ev , Alexander G. Balanov

A computational theory for classification of natural biosonar targets is developed based on the properties of an example stimulus ensemble. An extensive set of echoes (84 800) from four different foliages was transcribed into a spike code…

Biological Physics · Physics 2007-05-23 Rolf Mueller

Clustering algorithms are fundamental tools across many fields, with density-based methods offering particular advantages in identifying arbitrarily shaped clusters and handling noise. However, their effectiveness is often limited by the…

Machine Learning · Computer Science 2025-12-01 Meysam Shirdel Bilehsavar , Razieh Ghaedi , Samira Seyed Taheri , Xinqi Fan , Christian O'Reilly

Multi-swarm particle optimisation algorithms are gaining popularity due to their ability to locate multiple optimum points concurrently. In this family of algorithms, clustering-based multi-swarm algorithms are among the most effective…

Neural and Evolutionary Computing · Computer Science 2025-11-25 Yves Matanga , Yanxia Sun , Zenghui Wang

Spike detection plays a central role in neural data processing and brain-machine interfaces (BMIs). A challenge for future-generation implantable BMIs is to build a spike detector that features both low hardware cost and high performance.…

Signal Processing · Electrical Eng. & Systems 2022-08-30 Xiaorang Guo , MohammadAli Shaeri , Mahsa Shoaran

Much of studies on neural computation are based on network models of static neurons that produce analog output, despite the fact that information processing in the brain is predominantly carried out by dynamic neurons that produce discrete…

Neurons and Cognition · Quantitative Biology 2017-06-21 Dongsung Huh , Terrence J. Sejnowski

We consider a centralized detection problem where sensors experience noisy measurements and intermittent connectivity to a centralized fusion center. The sensors collaborate locally within predefined sensor clusters and fuse their noisy…

Signal Processing · Electrical Eng. & Systems 2022-08-23 Michal Yemini , Stephanie Gil , Andrea J. Goldsmith

The problem of clustering noisy and incompletely observed high-dimensional data points into a union of low-dimensional subspaces and a set of outliers is considered. The number of subspaces, their dimensions, and their orientations are…

Machine Learning · Statistics 2015-08-24 Reinhard Heckel , Helmut Bölcskei