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Early diagnosis of Alzheimer's disease (AD) is crucial in facilitating preventive care and to delay further progression. Speech based automatic AD screening systems provide a non-intrusive and more scalable alternative to other clinical…

Computation and Language · Computer Science 2023-04-03 Yi Wang , Jiajun Deng , Tianzi Wang , Bo Zheng , Shoukang Hu , Xunying Liu , Helen Meng

Early and accurate identification of parkinsonian syndromes (PS) involving presynaptic degeneration from non-degenerative variants such as Scans Without Evidence of Dopaminergic Deficit (SWEDD) and tremor disorders, is important for…

Applications · Statistics 2017-03-07 R. Prashanth , Sumantra Dutta Roy , Pravat K. Mandal , Shantanu Ghosh

Timely and accurate assessment of cognitive impairment remains a major unmet need. Speech biomarkers offer a scalable, non-invasive, cost-effective solution for automated screening. However, the clinical utility of machine learning (ML)…

Several machine learning algorithms have been developed for the prediction of Alzheimer's disease and related dementia (ADRD) from spontaneous speech. However, none of these algorithms have been translated for the prediction of broader…

This paper deals the combination of nonlinear predictive models with classical LPCC parameterization for speaker recognition. It is shown that the combination of both a measure defined over LPCC coefficients and a measure defined over…

Sound · Computer Science 2022-03-08 Marcos Faundez-Zanuy

Disease-modifying treatments are currently assessed in neurodegenerative diseases. Huntington's Disease represents a unique opportunity to design automatic sub-clinical markers, even in premanifest gene carriers. We investigated phonatory…

Audio and Speech Processing · Electrical Eng. & Systems 2020-08-03 Rachid Riad , Hadrien Titeux , Laurie Lemoine , Justine Montillot , Jennifer Hamet Bagnou , Xuan Nga Cao , Emmanuel Dupoux , Anne-Catherine Bachoud-Lévi

We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants…

Parkinsons Disease is a neurological disorder and prevalent in elderly people. Traditional ways to diagnose the disease rely on in-person subjective clinical evaluations on the quality of a set of activity tests. The high-resolution…

Machine Learning · Computer Science 2020-10-16 Weijian Li , Wei Zhu , E. Ray Dorsey , Jiebo Luo

This paper presents a new approach for classification of dysfluent and fluent speech using Mel-Frequency Cepstral Coefficient (MFCC). The speech is fluent when person's speech flows easily and smoothly. Sounds combine into syllable,…

Sound · Computer Science 2013-01-10 P. Mahesha , D. S. Vinod

This paper presents a study of the approaches in the state-of-the-art in the field of pathological speech signal analysis with a special focus on parametrization techniques. It provides a description of 92 speech features where some of them…

Lung diseases, including lung cancer and COPD, are significant health concerns globally. Traditional diagnostic methods can be costly, time-consuming, and invasive. This study investigates the use of semi supervised learning methods for…

Audio and Speech Processing · Electrical Eng. & Systems 2025-08-12 Xiaoran Xu , In-Ho Ra , Ravi Sankar

Falls are detrimental to people with Parkinson's Disease (PD) because of the potentially severe consequences to the patients' quality of life. While many studies have attempted to predict falls/non-falls, this study aimed to determine…

Applications · Statistics 2019-10-07 Sarini Abdullah , James McGree , Nicole White , Kerrie Mengersen , Graham Kerr

Parkinson's disease (PD) is a chronic neurodegenerative disease. It shows multiple motor symptoms such as tremor, bradykinesia, postural instability, freezing of gait (FoG). PD is currently diagnosed clinically through physical exam by…

Machine Learning · Computer Science 2026-04-21 Meheru Zannat

Multi-resolution spectro-temporal features of a speech signal represent how the brain perceives sounds by tuning cortical cells to different spectral and temporal modulations. These features produce a higher dimensional representation of…

Audio and Speech Processing · Electrical Eng. & Systems 2022-06-28 Rahil Parikh , Nadee Seneviratne , Ganesh Sivaraman , Shihab Shamma , Carol Espy-Wilson

Purpose: We introduce a novel methodology for voice pathology detection using the publicly available Saarbr\"ucken Voice Database (SVD) and a robust feature set combining commonly used acoustic handcrafted features with two novel ones:…

Atypical Parkinsonian Disorders (APD), also known as Parkinson-plus syndrome, are a group of neurodegenerative diseases that include progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). In the early stages, overlapping…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Mengyu Li , Ingibjörg Kristjánsdóttir , Thilo van Eimeren , Kathrin Giehl , Lotta M. Ellingsen , the ASAP Neuroimaging Initiative

Chronic Obstructive Pulmonary Disease (COPD) is a serious and debilitating disease affecting millions around the world. Its early detection using non-invasive means could enable preventive interventions that improve quality of life and…

Parkinson's Disease PD is a progressive neurodegenerative disorder that affects motor and cognitive functions with early diagnosis being critical for effective clinical intervention Electroencephalography EEG offers a noninvasive and…

We present our submission to the ICASSP-SPGC-2023 ADReSS-M Challenge Task, which aims to investigate which acoustic features can be generalized and transferred across languages for Alzheimer's Disease (AD) prediction. The challenge consists…

Computation and Language · Computer Science 2025-01-14 Xuchu Chen , Yu Pu , Jinpeng Li , Wei-Qiang Zhang

Perinatal depression (PND) affects 1 in 5 mothers, with 85% lacking support. Digital health tools offer early identification and prevention, potentially reducing PND risk by over 50% and improving engagement. Despite high interest, user…

Quantitative Methods · Quantitative Biology 2025-05-13 Rachel L. Wiley , Jim Schwoebel , Joel Shor , Bindu Chanagala , Matias Caccia , Adolfo M. García , Sheehan D. Fisher , Martin G. Frasch
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