Disease-modifying treatments are currently assessed in neurodegenerative diseases. Huntington's Disease represents a unique opportunity to design automatic sub-clinical markers, even in premanifest gene carriers. We investigated phonatory impairments as potential clinical markers and propose them for both diagnosis and gene carriers follow-up. We used two sets of features: Phonatory features and Modulation Power Spectrum Features. We found that phonation is not sufficient for the identification of sub-clinical disorders of premanifest gene carriers. According to our regression results, Phonatory features are suitable for the predictions of clinical performance in Huntington's Disease.
@article{arxiv.2006.05365,
title = {Vocal markers from sustained phonation in Huntington's Disease},
author = {Rachid Riad and Hadrien Titeux and Laurie Lemoine and Justine Montillot and Jennifer Hamet Bagnou and Xuan Nga Cao and Emmanuel Dupoux and Anne-Catherine Bachoud-Lévi},
journal= {arXiv preprint arXiv:2006.05365},
year = {2020}
}
Comments
To appear at INTERSPEECH 2020. 1 pages of supplementary material appear only in the arxiv version. Code to replicate https://github.com/bootphon/sustained-phonation-features