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Accurate drug-target interaction (DTI) prediction is essential for computational drug discovery, yet existing models often rely on single-modality predefined molecular descriptors or sequence-based embeddings with limited…
Contrastive Learning (CL) has emerged as a powerful method for training feature extraction models using unlabeled data. Recent studies suggest that incorporating a linear projection head post-backbone significantly enhances model…
Contrastive learning is a family of self-supervised methods where a model is trained to solve a classification task constructed from unlabeled data. It has recently emerged as one of the leading learning paradigms in the absence of labels…
Contrastive divergence is a popular method of training energy-based models, but is known to have difficulties with training stability. We propose an adaptation to improve contrastive divergence training by scrutinizing a gradient term that…
Contrastive learning has emerged as a competitive pretraining method for object detection. Despite this progress, there has been minimal investigation into the robustness of contrastively pretrained detectors when faced with domain shifts.…
Deep neural networks excel at comprehending complex visual signals, delivering on par or even superior performance to that of human experts. However, ad-hoc visual explanations of model decisions often reveal an alarming level of reliance…
Peptides play a pivotal role in a wide range of biological activities through participating in up to 40% protein-protein interactions in cellular processes. They also demonstrate remarkable specificity and efficacy, making them promising…
Mixture models are well-established learning approaches that, in computer vision, have mostly been applied to inverse or ill-defined problems. However, they are general-purpose divide-and-conquer techniques, splitting the input space into…
Background:Typically, proteins perform key biological functions by interacting with each other. As a consequence, predicting which protein pairs interact is a fundamental problem. Experimental methods are slow, expensive, and may be error…
Contrastive learning is a cornerstone underlying recent progress in multi-view and multimodal learning, e.g., in representation learning with image/caption pairs. While its effectiveness is not yet fully understood, a line of recent work…
Contrastive representation learning has emerged as a promising technique for continual learning as it can learn representations that are robust to catastrophic forgetting and generalize well to unseen future tasks. Previous work in…
Recently supervised machine learning has been ascending in providing new predictive approaches for chemical, biological and materials sciences applications. In this Perspective we focus on the interplay of machine learning algorithm with…
Protein contacts provide key information for the understanding of protein structure and function, and therefore contact prediction from sequences is an important problem. Recent research shows that some correctly predicted long-range…
Contrastive learning, a dominant self-supervised technique, emphasizes similarity in representations between augmentations of the same input and dissimilarity for different ones. Although low contrastive loss often correlates with high…
To reach human performance on complex tasks, a key ability for artificial systems is to understand physical interactions between objects, and predict future outcomes of a situation. This ability, often referred to as intuitive physics, has…
A data augmentation module is utilized in contrastive learning to transform the given data example into two views, which is considered essential and irreplaceable. However, the predetermined composition of multiple data augmentations brings…
Learnable keypoint detectors and descriptors are beginning to outperform classical hand-crafted feature extraction methods. Recent studies on self-supervised learning of visual representations have driven the increasing performance of…
Salient objects attract human attention and usually stand out clearly from their surroundings. In contrast, camouflaged objects share similar colors or textures with the environment. In this case, salient objects are typically…
Creating representations of shapes that are invari-ant to isometric or almost-isometric transforma-tions has long been an area of interest in shape anal-ysis, since enforcing invariance allows the learningof more effective and robust shape…
Predicting human interaction is challenging as the on-going activity has to be inferred based on a partially observed video. Essentially, a good algorithm should effectively model the mutual influence between the two interacting subjects.…