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External beam X-ray therapy (XRT) and proton therapy (PT) are effective and widely accepted forms of treatment for many types of cancer. However, the procedures require extensive computerized planning. Current planning systems for both XRT…

Graphics · Computer Science 2018-11-30 Felix G. Hamza-Lup , Shane Farrar , Erik Leon

The proton radiography diagnostic is widely used in laser-plasma experiments to make magnetic field measurements. Recent developments in analysis have enabled quantitative reconstruction of path-integrated magnetic field values, but making…

Recent developments for the delivery of proton and ion beam therapy have been significant, and a number of technological solutions now exist for the creation and utilisation of these particles for the treatment of cancer. In this paper we…

Accelerator Physics · Physics 2015-06-17 Hywel Owen , David Holder , Jose Alonso , Ranald MacKay

Stereotactic body radiation therapy (SBRT) and hypofractionation using pencil-beam scanning (PBS) proton therapy (PBSPT) is an attractive option for thoracic malignancies. Combining the advantages of target coverage conformity and critical…

Proton radiography has proved increasingly successful as a diagnostic for electric and magnetic fields in high energy density physics experiments. Most experiments use target-normal-sheath-acceleration sources with a wide energy range in…

Plasma Physics · Physics 2021-07-16 Christopher Arran , Christopher P. Ridgers , Nigel C. Woolsey

Treating cancer is one of the most challenging task in medical sciences. Only limited types of cancer treatments are available as their study is still ongoing. The earlier therapies like radiotherapy with x-rays, chemotherapy are associated…

Accelerator Physics · Physics 2024-06-06 R. Kanishka

We summarize recent results and ongoing activities in mathematical algorithms and computer science methods related to proton computed tomography (pCT) and intensity-modulated particle therapy (IMPT) treatment planning. Proton therapy…

Medical Physics · Physics 2021-08-24 Yair Censor , Keith E. Schubert , Reinhard W. Schulte

We developed a novel gamma-ray detection system (TIARA) for range monitoring in Particle Therapy. The system employs Cherenkov-based gamma-ray detection modules arranged around the target or patient, operated in time coincidence with a fast…

Proton (and ion) cancer therapy has proven to be an extremely effective even supe-rior method of treatment for some tumors 1-4. A major problem, however, lies in the cost of the particle accelerator facilities; high procurement costs…

Proton radiography combined with X-ray computed tomography (CT) has been proposed to obtain a patient-specific calibration curve and reduce range uncertainties in cancer treatment with charged particles. The main aim of this study was to…

The radiotherapy of malignant diseases has reached much progress during the past decade. Thus, intensity modulated radiation therapy (IMRT) and VMAT (Rapidarc) now belong to the standard modalities of tumor treatment with high energy…

Medical Physics · Physics 2016-11-15 W. Ulmer , A. Carabe-Fernandez

Proton radiography is a useful diagnostic of high energy density (HED) plasmas under active theoretical and experimental development. In this paper we describe a new simulation tool that interacts realistic laser-driven point-like proton…

Proton computed tomography (pCT) is a novel imaging modality developed for patients receiving proton radiation therapy. The purpose of this work was to investigate hull-detection algorithms used for preconditioning of the large and sparse…

Computer Vision and Pattern Recognition · Computer Science 2014-02-10 Blake Schultze , Micah Witt , Yair Censor , Reinhard Schulte , Keith Evan Schubert

Photons are exponentially attenuated in matter producing high doses close to the surface. Therefore they are not well suited for the treatment of deep seated tumours. Charged particles, in contrast, exhibit a sharp increase of ionisation…

Instrumentation and Detectors · Physics 2009-11-06 C. Grupen

Delineation of tumors and organs-at-risk permits detecting and correcting changes in the patients' anatomy throughout the treatment, making it a core step of adaptive proton therapy (APT). Although AI-based auto-contouring technologies have…

Background and Objective: Recent experimental studies using ultra-high dose rate radiation therapy (FLASH-RT) have shown improved normal tissue sparing and comparable tumor control compared to conventional dose rate RT. Pencil beam scanning…

Fast procedures for the beam quality assessment and for the monitoring of beam energy modulations during the irradiation are among the most urgent improvements in particle therapy. Indeed, the online measurement of the particle beam energy…

The distribution of the prompt gamma emissions induced by proton interactions in a target material carries information concerning the proton range and target composition. In order to image prompt gamma we present different approaches. The…

Uncertainties in the proton range in tissue during proton therapy limit the precision in treatment delivery. These uncertainties result in expanded treatment margins, thereby increasing radiation dose to healthy tissue. Real-time range…

Medical Physics · Physics 2018-10-17 Kristian Smeland Ytre-Hauge , Kyrre Skjerdal , John Mattingly , Ilker Meric

Proton radiography is used for advanced hydrotesting as a new type radiography technology due to its powerful penetration capability and high detection efficiency. A new proton radiography terminal will be developed to radiograph static…

Accelerator Physics · Physics 2015-01-28 Yan Yan , Li-Na Sheng , Zhi-Wu Huang , Jie Wang , Ze-En Yao , Jun-Run Wang , Zheng Wei , Jian-Cheng Yang , You-Jin Yuan