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Diagnosing rare diseases presents a common challenge in clinical practice, necessitating the expertise of specialists for accurate identification. The advent of machine learning offers a promising solution, while the development of such…

Machine Learning · Computer Science 2024-03-12 Yifan Wu , Yang Liu , Yue Yang , Michael S. Yao , Wenli Yang , Xuehui Shi , Lihong Yang , Dongjun Li , Yueming Liu , James C. Gee , Xuan Yang , Wenbin Wei , Shi Gu

Medical coding, the translation of unstructured clinical text into standardized medical codes, is a crucial but time-consuming healthcare practice. Though large language models (LLM) could automate the coding process and improve the…

Computation and Language · Computer Science 2025-03-25 John Wu , David Wu , Jimeng Sun

Explainability has been a challenge in AI for as long as AI has existed. With the recently increased use of AI in society, it has become more important than ever that AI systems would be able to explain the reasoning behind their results…

Artificial Intelligence · Computer Science 2020-09-30 Kary Främling

Machine reasoning has made great progress in recent years owing to large language models (LLMs). In the clinical domain, however, most NLP-driven projects mainly focus on clinical classification or reading comprehension, and under-explore…

Computation and Language · Computer Science 2024-05-13 Taeyoon Kwon , Kai Tzu-iunn Ong , Dongjin Kang , Seungjun Moon , Jeong Ryong Lee , Dosik Hwang , Yongsik Sim , Beomseok Sohn , Dongha Lee , Jinyoung Yeo

We developed an inherently interpretable multilevel Bayesian framework for representing variation in regression coefficients that mimics the piecewise linearity of ReLU-activated deep neural networks. We used the framework to formulate a…

Computers and Society · Computer Science 2023-01-31 Joshua C. Chang , Ted L. Chang , Carson C. Chow , Rohit Mahajan , Sonya Mahajan , Joe Maisog , Shashaank Vattikuti , Hongjing Xia

Machines are being increasingly used in decision-making processes, resulting in the realization that decisions need explanations. Unfortunately, an increasing number of these deployed models are of a 'black-box' nature where the reasoning…

Artificial Intelligence · Computer Science 2023-11-07 Sopam Dasgupta

Human-annotated textual explanations are becoming increasingly important in Explainable Natural Language Processing. Rationale extraction aims to provide faithful (i.e., reflective of the behavior of the model) and plausible (i.e.,…

Computation and Language · Computer Science 2023-10-24 Mohammad Reza Ghasemi Madani , Pasquale Minervini

In a striking neuroscience study, the authors placed a dead salmon in an MRI scanner and showed it images of humans in social situations. Astonishingly, standard analyses of the time reported brain regions predictive of social emotions. The…

Artificial Intelligence · Computer Science 2025-12-23 Maxime Méloux , Giada Dirupo , François Portet , Maxime Peyrard

In recent years, cross-modal reasoning (CMR), the process of understanding and reasoning across different modalities, has emerged as a pivotal area with applications spanning from multimedia analysis to healthcare diagnostics. As the…

Artificial Intelligence · Computer Science 2023-09-15 Dizhan Xue , Shengsheng Qian , Zuyi Zhou , Changsheng Xu

The integration of artificial intelligence (AI) into medicine is remarkable, offering advanced diagnostic and therapeutic possibilities. However, the inherent opacity of complex AI models presents significant challenges to their clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Binbin Wen , Yihang Wu , Tareef Daqqaq , Ahmad Chaddad

Extracting structured information from clinical notes requires navigating a dense web of interdependent variables where the value of one attribute logically constrains others. Existing Large Language Model (LLM)-based extraction pipelines…

Clinical text provides essential information to estimate the acuity of a patient during hospital stays in addition to structured clinical data. In this study, we explore how clinical text can complement a clinical predictive learning task.…

Diagnosis prediction is a critical task in healthcare, where timely and accurate identification of medical conditions can significantly impact patient outcomes. Traditional machine learning and deep learning models have achieved notable…

Machine Learning · Computer Science 2025-01-09 Qiuhao Lu , Rui Li , Elham Sagheb , Andrew Wen , Jinlian Wang , Liwei Wang , Jungwei W. Fan , Hongfang Liu

Electronic health records (EHRs), digital collections of patient healthcare events and observations, are ubiquitous in medicine and critical to healthcare delivery, operations, and research. Despite this central role, EHRs are notoriously…

Patients increasingly rely on online reviews when choosing healthcare providers, yet the sheer volume of these reviews can hinder effective decision-making. This paper summarises a mixed-methods study aimed at evaluating a proposed…

Computers and Society · Computer Science 2026-03-03 Eman Alamoudi , Ellis Solaiman

Clinical AI adoption is hindered by the black-box/grey-box nature of high-performing models, which lack the ontological grounding and narrative transparency required for professional-level explainability. We present NEURON, a neuro-symbolic…

Artificial Intelligence · Computer Science 2026-05-05 Anuradha Chandrasekaran , Dimitrios Zikos , Mutlu Mete , Alan Pang , Brady D. Lund , Kewei Sha

The increasing use of machine learning in clinical decision support has been limited by the lack of transparency of many high-performing models. In clinical settings, predictions must be interpretable, auditable, and actionable. This study…

Electronic health records (EHRs) are long, noisy, and often redundant, posing a major challenge for the clinicians who must navigate them. Large language models (LLMs) offer a promising solution for extracting and reasoning over this…

Computation and Language · Computer Science 2025-08-21 Skatje Myers , Dmitriy Dligach , Timothy A. Miller , Samantha Barr , Yanjun Gao , Matthew Churpek , Anoop Mayampurath , Majid Afshar

Accurate prediction of clinical outcomes using Electronic Health Records (EHRs) is critical for early intervention, efficient resource allocation, and improved patient care. EHRs contain multimodal data, including both structured data and…

Machine Learning · Computer Science 2025-08-29 Rituparna Datta , Jiaming Cui , Zihan Guan , Vishal G. Reddy , Joshua C. Eby , Gregory Madden , Rupesh Silwal , Anil Vullikanti

Despite recent advances in machine learning and explainable AI, a gap remains in personalized preventive healthcare: predictions, interventions, and recommendations should be both understandable and verifiable for all stakeholders in the…