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Machine learning methods are increasingly applied in medical imaging, yet many reported improvements lack statistical robustness: recent works have highlighted that small but significant performance gains are highly likely to be false…

Machine Learning · Computer Science 2025-11-05 Thomas Sanchez , Pedro M. Gordaliza , Meritxell Bach Cuadra

A third of adults in America use the Internet to diagnose medical concerns, and online symptom checkers are increasingly part of this process. These tools are powered by diagnosis models similar to clinical decision support systems, with…

Machine Learning · Computer Science 2019-12-18 Anitha Kannan , Jason Alan Fries , Eric Kramer , Jen Jen Chen , Nigam Shah , Xavier Amatriain

Machine learning models provide statistically impressive results which might be individually unreliable. To provide reliability, we propose an Epistemic Classifier (EC) that can provide justification of its belief using support from the…

Machine Learning · Computer Science 2020-10-20 Chitresh Bhushan , Zhaoyuan Yang , Nurali Virani , Naresh Iyer

Model explainability is essential for the creation of trustworthy Machine Learning models in healthcare. An ideal explanation resembles the decision-making process of a domain expert and is expressed using concepts or terminology that is…

Machine Learning · Computer Science 2021-07-14 Sumedha Singla , Stephen Wallace , Sofia Triantafillou , Kayhan Batmanghelich

Consistency models have emerged as a promising alternative to diffusion models, offering high-quality generative capabilities through single-step sample generation. However, their application to multi-domain image translation tasks, such as…

Computer Vision and Pattern Recognition · Computer Science 2025-01-06 Amil Bhagat , Milind Jain , A. V. Subramanyam

Machine learning (ML) models show strong promise for new biomedical prediction tasks, but concerns about trustworthiness have hindered their clinical adoption. In particular, it is often unclear whether a model relies on true clinical cues…

Machine Learning · Computer Science 2026-01-13 Dushan N. Wadduwage , Dineth Jayakody , Leonidas Zimianitis

Deep learning has played a major role in the interpretation of dermoscopic images for detecting skin defects and abnormalities. However, current deep learning solutions for dermatological lesion analysis are typically limited in providing…

Computer Vision and Pattern Recognition · Computer Science 2021-07-20 Gun-Hee Lee , Han-Bin Ko , Seong-Whan Lee

Complex systems can be modelled at various levels of detail. Ideally, causal models of the same system should be consistent with one another in the sense that they agree in their predictions of the effects of interventions. We formalise…

Explainability of black-box machine learning models is crucial, in particular when deployed in critical applications such as medicine or autonomous cars. Existing approaches produce explanations for the predictions of models, however, how…

Machine Learning · Computer Science 2021-11-18 Jonas Schulz , Rafael Poyiadzi , Raul Santos-Rodriguez

Electronic health records are an increasingly important resource for understanding the interactions between patient health, environment, and clinical decisions. In this paper we report an empirical study of predictive modeling of several…

Computers and Society · Computer Science 2019-03-29 William La Cava , Christopher Bauer , Jason H. Moore , Sarah A Pendergrass

Deep Learning of neural networks has progressively become more prominent in healthcare with models reaching, or even surpassing, expert accuracy levels. However, these success stories are tainted by concerning reports on the lack of model…

Machine Learning · Computer Science 2021-11-02 Matthew Watson , Bashar Awwad Shiekh Hasan , Noura Al Moubayed

Explaining the predictions made by complex machine learning models helps users to understand and accept the predicted outputs with confidence. One promising way is to use similarity-based explanation that provides similar instances as…

Machine Learning · Computer Science 2021-03-24 Kazuaki Hanawa , Sho Yokoi , Satoshi Hara , Kentaro Inui

Confidence estimation, a task that aims to evaluate the trustworthiness of the model's prediction output during deployment, has received lots of research attention recently, due to its importance for the safe deployment of deep models.…

Computer Vision and Pattern Recognition · Computer Science 2022-10-14 Haoxuan Qu , Yanchao Li , Lin Geng Foo , Jason Kuen , Jiuxiang Gu , Jun Liu

In spite of the strong performance of machine learning (ML) models in radiology, they have not been widely accepted by radiologists, limiting clinical integration. A key reason is the lack of explainability, which ensures that model…

Human-Computer Interaction · Computer Science 2026-04-14 Sara Ketabi , Matthias W. Wagner , Birgit Betina Ertl-Wagner , Greg A. Jamieson , Farzad Khalvati

Computer-aided diagnosis (CAD), a vibrant medical imaging research field, is expanding quickly. Because errors in medical diagnostic systems might lead to seriously misleading medical treatments, major efforts have been made in recent years…

Machine Learning · Computer Science 2023-08-04 Farzaneh Tajidini , Mohammad-Javad Kheiri

We consider a classifier whose test set is exposed to various perturbations that are not present in the training set. These test samples still contain enough features to map them to the same class as their unperturbed counterpart. Current…

Computer Vision and Pattern Recognition · Computer Science 2018-12-04 Yuchen Li , Safwan Hossain , Kiarash Jamali , Frank Rudzicz

Deep Learning sets the state-of-the-art in many challenging tasks showing outstanding performance in a broad range of applications. Despite its success, it still lacks robustness hindering its adoption in medical applications. Modeling…

Computer Vision and Pattern Recognition · Computer Science 2019-09-19 Agnieszka Tomczack , Nassir Navab , Shadi Albarqouni

Medical image classification is a critical problem for healthcare, with the potential to alleviate the workload of doctors and facilitate diagnoses of patients. However, two challenges arise when deploying deep learning models to real-world…

Computer Vision and Pattern Recognition · Computer Science 2023-10-06 An Yan , Yu Wang , Yiwu Zhong , Zexue He , Petros Karypis , Zihan Wang , Chengyu Dong , Amilcare Gentili , Chun-Nan Hsu , Jingbo Shang , Julian McAuley

Magnetic resonance spectroscopic imaging is a widely available imaging modality that can non-invasively provide a metabolic profile of the tissue of interest, yet is challenging to integrate clinically. One major reason is the expensive,…

Computer Vision and Pattern Recognition · Computer Science 2024-09-11 John LaMaster , Dhritiman Das , Florian Kofler , Jason Crane , Yan Li , Tobias Lasser , Bjoern H Menze

The adoption of machine learning in high-stakes applications such as healthcare and law has lagged in part because predictions are not accompanied by explanations comprehensible to the domain user, who often holds the ultimate…