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In many settings, it is important that a model be capable of providing reasons for its predictions (i.e., the model must be interpretable). However, the model's reasoning may not conform with well-established knowledge. In such cases, while…

Machine Learning · Computer Science 2019-02-19 Jiaxuan Wang , Jeeheh Oh , Haozhu Wang , Jenna Wiens

Deep neural networks for medical image classification often fail to generalize consistently in clinical practice due to violations of the i.i.d. assumption and opaque decision-making. This paper examines interpretability in deep neural…

Computer Vision and Pattern Recognition · Computer Science 2025-04-09 Mohammad Hossein Najafi , Mohammad Morsali , Mohammadreza Pashanejad , Saman Soleimani Roudi , Mohammad Norouzi , Saeed Bagheri Shouraki

In this study, we present a novel clinical decision support system and discuss its interpretability-related properties. It combines a decision set of rules with a machine learning scheme to offer global and local interpretability. More…

Methodology · Statistics 2021-07-16 Francisco Valente , Simão Paredes , Jorge Henriques

The use of machine learning to develop intelligent software tools for interpretation of radiology images has gained widespread attention in recent years. The development, deployment, and eventual adoption of these models in clinical…

Machine Learning · Computer Science 2021-02-04 Viraj Kulkarni , Manish Gawali , Amit Kharat

Discriminative classifiers have become a foundational tool in deep learning for medical imaging, excelling at learning separable features of complex data distributions. However, these models often need careful design, augmentation, and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Gian Mario Favero , Parham Saremi , Emily Kaczmarek , Brennan Nichyporuk , Tal Arbel

In the field of medical image analysis, achieving high accuracy is not enough; ensuring well-calibrated predictions is also crucial. Confidence scores of a deep neural network play a pivotal role in explainability by providing insights into…

Computer Vision and Pattern Recognition · Computer Science 2023-12-05 Abhishek Singh Sambyal , Usma Niyaz , Narayanan C. Krishnan , Deepti R. Bathula

Machine learning plays an increasingly significant role in many aspects of our lives (including medicine, transportation, security, justice and other domains), making the potential consequences of false predictions increasingly devastating.…

Computer Vision and Pattern Recognition · Computer Science 2020-07-01 Yuval Bahat , Gregory Shakhnarovich

In this paper, for the first time, we propose an evaluation method for deep learning models that assesses the performance of a model not only in an unseen test scenario, but also in extreme cases of noise, outliers and ambiguous input data.…

Computer Vision and Pattern Recognition · Computer Science 2018-04-03 Magdalini Paschali , Sailesh Conjeti , Fernando Navarro , Nassir Navab

Various AI models are increasingly being considered as part of clinical decision-support tools. However, the trustworthiness of such models is rarely considered. Clinicians are more likely to use a model if they can understand and trust its…

Artificial Intelligence · Computer Science 2020-03-09 Evangelia Kyrimi , Somayyeh Mossadegh , Nigel Tai , William Marsh

Trust is a crucial factor affecting the adoption of machine learning (ML) models. Qualitative studies have revealed that end-users, particularly in the medical domain, need models that can express their uncertainty in decision-making…

Machine Learning · Computer Science 2023-04-21 Andrew Houston , Georgina Cosma

In clinical practice, decision-making relies heavily on established protocols, often formalised as rules. Concurrently, Machine Learning (ML) models, trained on clinical data, aspire to integrate into medical decision-making processes.…

Artificial Intelligence · Computer Science 2024-11-06 Christel Sirocchi , Muhammad Suffian , Federico Sabbatini , Alessandro Bogliolo , Sara Montagna

Existing interpretation algorithms have found that, even deep models make the same and right predictions on the same image, they might rely on different sets of input features for classification. However, among these sets of features, some…

Machine Learning · Computer Science 2021-09-03 Xuhong Li , Haoyi Xiong , Siyu Huang , Shilei Ji , Dejing Dou

In mission-critical domains such as law enforcement and medical diagnosis, the ability to explain and interpret the outputs of deep learning models is crucial for ensuring user trust and supporting informed decision-making. Despite…

Computer Vision and Pattern Recognition · Computer Science 2024-11-07 Bharat Chandra Yalavarthi , Nalini Ratha

Databases of electronic health records (EHRs) are increasingly used to inform clinical decisions. Machine learning methods can find patterns in EHRs that are predictive of future adverse outcomes. However, statistical models may be built…

Machine Learning · Statistics 2018-12-04 Andrew C. Miller , Ziad Obermeyer , Sendhil Mullainathan

Machine Learning (ML) models have gained popularity in medical imaging analysis given their expert level performance in many medical domains. To enhance the trustworthiness, acceptance, and regulatory compliance of medical imaging models…

Human-Computer Interaction · Computer Science 2025-06-06 Mischa Dombrowski , Andrea Prenner , Bernhard Kainz

Classification models are very sensitive to data uncertainty, and finding robust classifiers that are less sensitive to data uncertainty has raised great interest in the machine learning literature. This paper aims to construct robust…

Machine Learning · Statistics 2022-03-01 Vali Asimit , Ioannis Kyriakou , Simone Santoni , Salvatore Scognamiglio , Rui Zhu

Understanding why a classification model prefers one class over another for an input instance is the challenge of contrastive explanation. This work implements concept-based contrastive explanations for image classification by leveraging…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Yuliia Kaidashova , Bettina Finzel , Ute Schmid

Over the last decade, the development of deep image classification networks has mostly been driven by the search for the best performance in terms of classification accuracy on standardized benchmarks like ImageNet. More recently, this…

Computer Vision and Pattern Recognition · Computer Science 2021-08-20 Kalun Ho , Franz-Josef Pfreundt , Janis Keuper , Margret Keuper

To date, the instability of prognostic predictors in a sparse high dimensional model, which hinders their clinical adoption, has received little attention. Stable prediction is often overlooked in favour of performance. Yet, stability…

Machine Learning · Statistics 2016-09-29 Shivapratap Gopakumar , Truyen Tran , Dinh Phung , Svetha Venkatesh

In a data-scarce field such as healthcare, where models often deliver predictions on patients with rare conditions, the ability to measure the uncertainty of a model's prediction could potentially lead to improved effectiveness of decision…

Machine Learning · Statistics 2020-05-26 Lotta Meijerink , Giovanni Cinà , Michele Tonutti