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In many tissues, cell type varies over single-cell length-scales, creating detailed spatial heterogeneities fundamental to physiological function. To gain understanding of this relationship between tissue function and detailed structure,…

We propose an end-to-end deep learning architecture that produces a 3D shape in triangular mesh from a single color image. Limited by the nature of deep neural network, previous methods usually represent a 3D shape in volume or point cloud,…

Computer Vision and Pattern Recognition · Computer Science 2018-08-06 Nanyang Wang , Yinda Zhang , Zhuwen Li , Yanwei Fu , Wei Liu , Yu-Gang Jiang

Numerical investigation of the interaction of electromagnetic fields with eukaryotic cells requires specifically adapted computer models. Virtual microdosimetry, used to investigate exposure, requires volumetric cell models, which are…

Conventional 2-D scanning electron microscopy (SEM) is commonly used to rapidly and qualitatively evaluate membrane pore structure. Quantitative 2-D analyses of pore sizes can be extracted from SEM, but without information about 3-D spatial…

The dynamics of suspended two-dimensional (2D) materials has received increasing attention during the last decade, yielding new techniques to study and interpret the physics that governs the motion of atomically thin layers. This has led to…

Mesoscale and Nanoscale Physics · Physics 2021-09-01 Peter G. Steeneken , Robin J. Dolleman , Dejan Davidovikj , Farbod Alijani , Herre S. J. van der Zant

We introduce GEM3D -- a new deep, topology-aware generative model of 3D shapes. The key ingredient of our method is a neural skeleton-based representation encoding information on both shape topology and geometry. Through a denoising…

Computer Vision and Pattern Recognition · Computer Science 2024-04-12 Dmitry Petrov , Pradyumn Goyal , Vikas Thamizharasan , Vladimir G. Kim , Matheus Gadelha , Melinos Averkiou , Siddhartha Chaudhuri , Evangelos Kalogerakis

Methods allowing the synthesis of realistic cell shapes could help generate training data sets to improve cell tracking and segmentation in biomedical images. Deep generative models for cell shape synthesis require a light-weight and…

Computer Vision and Pattern Recognition · Computer Science 2022-10-07 David Wiesner , Julian Suk , Sven Dummer , David Svoboda , Jelmer M. Wolterink

D shape generation is a fundamental operation in computer graphics. While significant progress has been made, especially with recent deep generative models, it remains a challenge to synthesize high-quality shapes with rich geometric…

Graphics · Computer Science 2022-05-31 Jie Yang , Kaichun Mo , Yu-Kun Lai , Leonidas J. Guibas , Lin Gao

The orientation of cell division is a major determinant of three-dimensional plant morphogenesis. Whether and how a simple division orientation rule explains the establishment of symmetric body plans is a fundamental question. Testing such…

Cell Behavior · Quantitative Biology 2026-05-14 Naoya Kamamoto , Koichi Fujimoto

We discuss the role coarse-grained models play in the investigation of the structure and thermodynamics of bilayer membranes, and we place them in the context of alternative approaches. Because they reduce the degrees of freedom and employ…

Soft Condensed Matter · Physics 2009-11-11 Marcus Mueller , Kirill Katsov , Michael Schick

Parametric 3D models have enabled a wide variety of computer vision and graphics tasks, such as modeling human faces, bodies and hands. In 3D face modeling, 3DMM is the most widely used parametric model, but can't generate fine geometric…

Computer Vision and Pattern Recognition · Computer Science 2024-06-17 Haitao Cao , Baoping Cheng , Qiran Pu , Haocheng Zhang , Bin Luo , Yixiang Zhuang , Juncong Lin , Liyan Chen , Xuan Cheng

Direct numerical simulation of microscale fluid--structure interactions in multicomponent and multiphase flows requires methods that can represent moving boundaries together with fields constrained to evolving interfaces. Diffuse-domain…

Biological Physics · Physics 2026-05-14 Xinpeng Xu

The Molecular Distance Geometry Problem (MDGP) is essential in structural biology, as it seeks to determine three-dimensional protein structures from partial interatomic distances. Its discretizable subclass (DMDGP) admits an exact…

Optimization and Control · Mathematics 2025-10-24 Leonardo D. Secchin , Wagner da Rocha , Mariana da Rosa , Leo Liberti , Carlile Lavor

Model-free data-driven computational mechanics (DDCM) is a new paradigm for simulations in solid mechanics. The modeling step associated to the definition of a material constitutive law is circumvented through the introduction of an…

Materials Science · Physics 2023-10-23 Sacha Wattel , Jean-François Molinari , Michael Ortiz , Joaquin Garcia-Suarez

Deep learning-based medical image segmentation and surface mesh generation typically involve a sequential pipeline from image to segmentation to meshes, often requiring large training datasets while making limited use of prior geometric…

Recent generative models can create visually plausible 3D representations of objects. However, the generation process often allows for implicit control signals, such as contextual descriptions, and rarely supports bold geometric distortions…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Changwoon Choi , Hyunsoo Lee , Clément Jambon , Yael Vinker , Young Min Kim

Deep generative models have shown success in generating 3D shapes with different representations. In this work, we propose Neural Volumetric Mesh Generator(NVMG) which can generate novel and high-quality volumetric meshes. Unlike the…

Computer Vision and Pattern Recognition · Computer Science 2022-10-10 Yan Zheng , Lemeng Wu , Xingchao Liu , Zhen Chen , Qiang Liu , Qixing Huang

Signal transduction and cell function are governed by the spatiotemporal organization of membrane-associated molecules. Despite significant advances in visualizing molecular distributions by 3D light microscopy, cell biologists still have…

Quantitative Methods · Quantitative Biology 2023-04-14 Felix Y. Zhou , Andrew Weems , Gabriel M. Gihana , Bingying Chen , Bo-Jui Chang , Meghan Driscoll , Gaudenz Danuser

Probabilistic denoising diffusion models (DDMs) have set a new standard for 2D image generation. Extending DDMs for 3D content creation is an active field of research. Here, we propose TetraDiffusion, a diffusion model that operates on a…

Computer Vision and Pattern Recognition · Computer Science 2024-08-12 Nikolai Kalischek , Torben Peters , Jan D. Wegner , Konrad Schindler

Computational methods that operate on three-dimensional molecular structure have the potential to solve important questions in biology and chemistry. In particular, deep neural networks have gained significant attention, but their…