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The characterization of exoplanet requires reliable determination of the fundamental parameters of their host stars. Spectral fitting plays an important role in this process. For the majority of stellar parameters matching synthetic spectra…

Solar and Stellar Astrophysics · Physics 2023-03-29 Ansgar Wehrhahn , Nikolai Piskunov , Tanja Ryabchikova

Machine learning models have found numerous successful applications in computational drug discovery. A large body of these models represents molecules as sequences since molecular sequences are easily available, simple, and informative. The…

Surface-enhanced Raman spectroscopy (SERS) is a potential fast and inexpensive method of analyte quantification, which can be combined with deep learning to discover biomarker-disease relationships. This study aims to address present…

Quantitative Methods · Quantitative Biology 2024-11-14 Jihan K. Zaki , Jakub Tomasik , Jade A. McCune , Sabine Bahn , Pietro Liò , Oren A. Scherman

Artificial intelligence (AI) and machine learning (ML) are expanding in popularity for broad applications to challenging tasks in chemistry and materials science. Examples include the prediction of properties, the discovery of new reaction…

Decoding fine-grained movement from non-invasive surface Electromyography (sEMG) is a challenge for prosthetic control due to signal non-stationarity and low signal-to-noise ratios. Generic self-supervised learning (SSL) frameworks often…

Human-Computer Interaction · Computer Science 2025-12-30 Zihan Weng , Chanlin Yi , Pouya Bashivan , Jing Lu , Fali Li , Dezhong Yao , Jingming Hou , Yangsong Zhang , Peng Xu

A proof-of-concept framework for identifying molecules of unknown elemental composition and structure using experimental rotational data and probabilistic deep learning is presented. Using a minimal set of input data determined…

Chemical Physics · Physics 2020-07-01 Michael C. McCarthy , Kin Long Kelvin Lee

Automatic extraction of chemical structures from scientific literature plays a crucial role in accelerating research across fields ranging from drug discovery to materials science. Patent documents, in particular, contain molecular…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Lucas Morin , Gerhard Ingmar Meijer , Valéry Weber , Luc Van Gool , Peter W. J. Staar

Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful and widely used tools for molecular structure elucidation in organic chemistry. However, the interpretation of NMR spectra to determine unknown molecular structures…

Chemical Physics · Physics 2025-09-03 Yongqi Jin , Jun-Jie Wang , Fanjie Xu , Xiaohong Ji , Zhifeng Gao , Linfeng Zhang , Guolin Ke , Rong Zhu , Weinan E

Stellar abundance analysis relies on flexible, high-performance spectral synthesis. To meet these needs, we present PySME v1.0, an updated Python implementation of Spectroscopy Made Easy (SME) designed for precise and survey-scale modelling…

Instrumentation and Methods for Astrophysics · Physics 2026-05-12 Mingjie Jian , Nikolai Piskunov , Jeff Valenti , Ella Xi Wang , Brian Thorsbro , Henrik Jönsson , Ansgar Wehrhahn

The extraction of molecular structures and reaction data from scientific documents is challenging due to their varied, unstructured chemical formats and complex document layouts. To address this, we introduce MolMole, a vision-based deep…

Spectropolarimetry, the observation of polarization and intensity as a function of wavelength, is a powerful tool in stellar astrophysics. It is particularly useful for characterizing stars and circumstellar material, and for tracing the…

Machine learning potentials are an important tool for molecular simulation, but their development is held back by a shortage of high quality datasets to train them on. We describe the SPICE dataset, a new quantum chemistry dataset for…

Machine learning (ML) offers powerful methods for detecting and modeling associations often in data with large feature spaces and complex associations. Many useful tools/packages (e.g. scikit-learn) have been developed to make the various…

Machine Learning · Computer Science 2022-06-27 Ryan J. Urbanowicz , Robert Zhang , Yuhan Cui , Pranshu Suri

In the computational prediction of chemical compound properties, molecular descriptors and fingerprints encoded to low dimensional vectors are used. The selection of proper molecular descriptors and fingerprints is both important and…

Machine Learning · Computer Science 2020-10-23 Sangrak Lim , Yong Oh Lee

The discovery and identification of molecules in biological and environmental samples is crucial for advancing biomedical and chemical sciences. Tandem mass spectrometry (MS/MS) is the leading technique for high-throughput elucidation of…

Context. A variety of laboratory ice spectra simulating different chemical environments, ice morphology as well as thermal and energetic processing are demanded to provide an accurate interpretation of the infrared spectra of protostars. To…

Instrumentation and Methods for Astrophysics · Physics 2021-10-27 Will R. M. Rocha , Giulia Perotti , Lars E. Kristensen , Jes K. Jørgensen

We introduce Group SELFIES, a molecular string representation that leverages group tokens to represent functional groups or entire substructures while maintaining chemical robustness guarantees. Molecular string representations, such as…

Machine Learning · Computer Science 2023-10-19 Austin Cheng , Andy Cai , Santiago Miret , Gustavo Malkomes , Mariano Phielipp , Alán Aspuru-Guzik

Motivation: The scalable identification of bioactive compounds is essential for contemporary drug discovery. This process faces a key trade-off: structural screening offers scalability but lacks biological context, whereas high-content…

Quantitative Methods · Quantitative Biology 2026-03-17 Xiaoqing Lian , Pengsen Ma , Tengfeng Ma , Zhonghao Ren , Xibao Cai , Zhixiang Cheng , Bosheng Song , He Wang , Xiang Pan , Yangyang Chen , Sisi Yuan , Chen Lin

Vibrational spectroscopy is an indispensable analytical tool that provides structural fingerprints for molecules, solids, and interfaces thereof. This study introduces THeSeuSS (THz Spectra Simulations Software) - an automated computational…

Materials Science · Physics 2024-09-11 Ariadni Boziki , Frédéric Ngono Mebenga , Philippe Fernandes , Alexandre Tkatchenko

Knowledge of mixtures' phase equilibria is crucial in nature and technical chemistry. Phase equilibria calculations of mixtures require activity coefficients. However, experimental data on activity coefficients is often limited due to high…

Chemical Physics · Physics 2023-09-22 Benedikt Winter , Clemens Winter , Johannes Schilling , André Bardow