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Multiple Instance Learning (MIL) is a popular weakly-supervised method for various applications, with a particular interest in histological whole slide image (WSI) classification. Due to the gigapixel resolution of WSI, applications of MIL…

Computer Vision and Pattern Recognition · Computer Science 2025-05-21 Wenhui Zhu , Peijie Qiu , Xiwen Chen , Zhangsihao Yang , Aristeidis Sotiras , Abolfazl Razi , Yalin Wang

Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani

Digitizing pathological images into gigapixel Whole Slide Images (WSIs) has opened new avenues for Computational Pathology (CPath). As positive tissue comprises only a small fraction of gigapixel WSIs, existing Multiple Instance Learning…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Wenhao Tang , Sheng Huang , Heng Fang , Fengtao Zhou , Bo Liu , Qingshan Liu

This paper introduces MAD-MIL, a Multi-head Attention-based Deep Multiple Instance Learning model, designed for weakly supervised Whole Slide Images (WSIs) classification in digital pathology. Inspired by the multi-head attention mechanism…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Hassan Keshvarikhojasteh , Josien Pluim , Mitko Veta

Since machine learning model is often trained on a limited data set, the model is trained multiple times on the same data sample, which causes the model to memorize most of the training set data. Membership Inference Attacks (MIAs) exploit…

Machine Learning · Computer Science 2024-11-19 Depeng Chen , Xiao Liu , Jie Cui , Hong Zhong

Multiple Instance Learning (MIL) has emerged as a promising paradigm for Whole Slide Image (WSI) diagnosis, offering effective learning with limited annotations. However, existing MIL frameworks overlook diagnostic priorities and fail to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Sungrae Hong , Jiwon Jeong , Jisu Shin , Donghee Han , Sol Lee , Kyungeun Kim , Mun Yong Yi

Log anomaly detection is a critical task for system operations and security assurance. However, in networked systems at scale, log data are generated at massive scale while instance-level annotations are prohibitively expensive, posing…

Machine Learning · Computer Science 2026-05-13 Yutszyuk Wong , Wentai Wu , Yuen-Ying Yeung , Weiwei Lin

Standard deep neural networks (DNNs) are commonly trained in an end-to-end fashion for specific tasks such as object recognition, face identification, or character recognition, among many examples. This specificity often leads to…

Computer Vision and Pattern Recognition · Computer Science 2020-07-14 Raphaël Achddou , J. Matias di Martino , Guillermo Sapiro

Whole-slide image classification represents a key challenge in computational pathology and medicine. Attention-based multiple instance learning (MIL) has emerged as an effective approach for this problem. However, the effect of attention…

Quantitative Methods · Quantitative Biology 2025-03-14 Rajiv Krishnakumar , Julien Baglio , Frederik F. Flöther , Christian Ruiz , Stefan Habringer , Nicole H. Romano

Noise transition matrix (NTM) estimation is a promising approach for learning with label noise. It can infer clean posterior probabilities, known as Label Distribution (LD), based on noisy ones and reduce the impact of noisy labels.…

Computer Vision and Pattern Recognition · Computer Science 2024-11-05 Zehui Liao , Shishuai Hu , Yutong Xie , Yong Xia

In many pattern recognition problems, a single feature vector is not sufficient to describe an object. In multiple instance learning (MIL), objects are represented by sets (\emph{bags}) of feature vectors (\emph{instances}). This requires…

Computer Vision and Pattern Recognition · Computer Science 2018-06-22 Veronika Cheplygina , David M. J. Tax

In this paper, we propose an extension to an existing algorithm (instance-MIR) which tackles the multiple instance regression (MIR) problem, also known as distribution regression. The MIR setting arises when the data is a collection of…

Machine Learning · Statistics 2019-08-20 Thomas Uriot

This paper presents the first attempt to learn semantic boundary detection using image-level class labels as supervision. Our method starts by estimating coarse areas of object classes through attentions drawn by an image classification…

Computer Vision and Pattern Recognition · Computer Science 2022-12-16 Namyup Kim , Sehyun Hwang , Suha Kwak

Deep neural networks, including transformers and convolutional neural networks, have significantly improved multivariate time series classification (MTSC). However, these methods often rely on supervised learning, which does not fully…

Machine Learning · Computer Science 2024-05-28 Xiwen Chen , Peijie Qiu , Wenhui Zhu , Huayu Li , Hao Wang , Aristeidis Sotiras , Yalin Wang , Abolfazl Razi

With the rapid development of facial manipulation techniques, face forgery has received considerable attention in multimedia and computer vision community due to security concerns. Existing methods are mostly designed for single-frame…

Computer Vision and Pattern Recognition · Computer Science 2020-08-12 Xiaodan Li , Yining Lang , Yuefeng Chen , Xiaofeng Mao , Yuan He , Shuhui Wang , Hui Xue , Quan Lu

Various multi-instance learning (MIL) based approaches have been developed and successfully applied to whole-slide pathological images (WSI). Existing MIL methods emphasize the importance of feature aggregators, but largely neglect the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Yicheng Song , Tiancheng Lin , Die Peng , Su Yang , Yi Xu

Few-shot Multi-label Intent Detection (MID) is crucial for dialogue systems, aiming to detect multiple intents of utterances in low-resource dialogue domains. Previous studies focus on a two-stage pipeline. They first learn representations…

Computation and Language · Computer Science 2025-10-10 Shiman Zhao , Shangyuan Li , Wei Chen , Tengjiao Wang , Jiahui Yao , Jiabin Zheng , Kam Fai Wong

Multiple instance learning (MIL) is a powerful tool to solve the weakly supervised classification in whole slide image (WSI) based pathology diagnosis. However, the current MIL methods are usually based on independent and identical…

Computer Vision and Pattern Recognition · Computer Science 2021-11-02 Zhuchen Shao , Hao Bian , Yang Chen , Yifeng Wang , Jian Zhang , Xiangyang Ji , Yongbing Zhang

Sebocytes are lipid-secreting cells whose differentiation is marked by the accumulation of intracellular lipid droplets, making their quantification a key readout in sebocyte biology. Manual counting is labor-intensive and subjective,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Maryam Adelipour , Gustavo Carneiro , Jeongkwon Kim

Whole Slide Images (WSIs) are high-resolution digital scans widely used in medical diagnostics. WSI classification is typically approached using Multiple Instance Learning (MIL), where the slide is partitioned into tiles treated as…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Sharon Peled , Yosef E. Maruvka , Moti Freiman