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We consider large-scale studies in which thousands of significance tests are performed simultaneously. In some of these studies, the multiple testing procedure can be severely biased by latent confounding factors such as batch effects and…

Methodology · Statistics 2016-06-21 Jingshu Wang , Qingyuan Zhao , Trevor Hastie , Art B. Owen

Results in epidemiology and social science often require the removal of confounding effects from measurements of the pairwise correlation of variables in survey data. This is typically accomplished by some variant of linear regression…

Methodology · Statistics 2025-12-02 William H. Press

Motivated by the simultaneous association analysis with the presence of latent confounders, this paper studies the large-scale hypothesis testing problem for the high-dimensional confounded linear models with both non-asymptotic and…

Methodology · Statistics 2023-08-24 Yinrui Sun , Li Ma , Yin Xia

We consider functional linear regression models where functional outcomes are associated with scalar predictors by coefficient functions with shape constraints, such as monotonicity and convexity, that apply to sub-domains of interest. To…

Methodology · Statistics 2025-05-09 Kyunghee Han , Yeonjoo Park , Soo-Young Kim

This paper addresses the problem of measurement errors in causal inference and highlights several algebraic and graphical methods for eliminating systematic bias induced by such errors. In particulars, the paper discusses the control of…

Methodology · Statistics 2012-03-19 Judea Pearl

A common assumption in causal inference from observational data is that there is no hidden confounding. Yet it is, in general, impossible to verify this assumption from a single dataset. Under the assumption of independent causal mechanisms…

Methodology · Statistics 2023-11-07 Rickard K. A. Karlsson , Jesse H. Krijthe

This research addresses the challenge of conducting interpretable causal inference between a binary treatment and its resulting outcome when not all confounders are known. Confounders are factors that have an influence on both the treatment…

Machine Learning · Computer Science 2023-10-24 Sohaib Kiani , Jared Barton , Jon Sushinsky , Lynda Heimbach , Bo Luo

The assumption of no unmeasured confounders is a critical but unverifiable assumption required for causal inference yet quantitative sensitivity analyses to assess robustness of real-world evidence remains underutilized. The lack of use is…

Unmeasured confounding is a major challenge for identifying causal relationships from non-experimental data. Here, we propose a method that can accommodate unmeasured discrete confounding. Extending recent identifiability results in deep…

Machine Learning · Computer Science 2024-08-13 Patrick Burauel , Frederick Eberhardt , Michel Besserve

Hidden confounding remains a central challenge in estimating treatment effects from observational data, as unobserved variables can lead to biased causal estimates. While recent work has explored the use of large language models (LLMs) for…

Computation and Language · Computer Science 2025-07-08 Hao Yang , Haoxuan Li , Luyu Chen , Haoxiang Wang , Xu Chen , Mingming Gong

In health related machine learning applications, the training data often corresponds to a non-representative sample from the target populations where the learners will be deployed. In anticausal prediction tasks, selection biases often make…

Machine Learning · Statistics 2020-11-10 Elias Chaibub Neto , Phil Snyder , Solveig K Sieberts , Larsson Omberg

Recently, interest has grown in the use of proxy variables of unobserved confounding for inferring the causal effect in the presence of unmeasured confounders from observational data. One difficulty inhibiting the practical use is finding…

Machine Learning · Computer Science 2024-05-28 Feng Xie , Zhengming Chen , Shanshan Luo , Wang Miao , Ruichu Cai , Zhi Geng

Causal approaches to fairness have seen substantial recent interest, both from the machine learning community and from wider parties interested in ethical prediction algorithms. In no small part, this has been due to the fact that causal…

Machine Learning · Computer Science 2019-08-17 Niki Kilbertus , Philip J. Ball , Matt J. Kusner , Adrian Weller , Ricardo Silva

The measurement of bias in machine learning often focuses on model performance across identity subgroups (such as man and woman) with respect to groundtruth labels. However, these methods do not directly measure the associations that a…

Computer Vision and Pattern Recognition · Computer Science 2021-06-08 Osman Aka , Ken Burke , Alex Bäuerle , Christina Greer , Margaret Mitchell

Statistical learning on biological data can be challenging due to confounding variables in sample collection and processing. Confounders can cause models to generalize poorly and result in inaccurate prediction performance metrics if models…

Machine Learning · Computer Science 2018-12-13 Tzu-Yu Liu , Ajay Kannan , Adam Drake , Marvin Bertin , Nathan Wan

Machine learning (ML) approaches to data analysis are now widely adopted in many fields including epidemiology and medicine. To apply these approaches, confounds must first be removed as is commonly done by featurewise removal of their…

Survey weighting allows researchers to account for bias in survey samples, due to unit nonresponse or convenience sampling, using measured demographic covariates. Unfortunately, in practice, it is impossible to know whether the estimated…

Methodology · Statistics 2023-03-07 Erin Hartman , Melody Huang

Performing causal inference in observational studies requires we assume confounding variables are correctly adjusted for. G-computation methods are often used in these scenarios, with several recent proposals using Bayesian versions of…

Methodology · Statistics 2021-10-25 Daniel Daly-Grafstein , Paul Gustafson

Various methods have recently been proposed to estimate causal effects with confidence intervals that are uniformly valid over a set of data generating processes when high-dimensional nuisance models are estimated by post-model-selection or…

Methodology · Statistics 2025-10-07 Niloofar Moosavi , Tetiana Gorbach , Xavier de Luna

In observational studies, identification of ATEs is generally achieved by assuming that the correct set of confounders has been measured and properly included in the relevant models. Because this assumption is both strong and untestable, a…

Methodology · Statistics 2020-12-18 Matteo Bonvini , Edward H Kennedy