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Fully convolutional neural networks (FCNs), and in particular U-Nets, have achieved state-of-the-art results in semantic segmentation for numerous medical imaging applications. Moreover, batch normalization and Dice loss have been used…

Image and Video Processing · Electrical Eng. & Systems 2020-07-06 Alireza Mehrtash , William M. Wells , Clare M. Tempany , Purang Abolmaesumi , Tina Kapur

Deep-learning has proved in recent years to be a powerful tool for image analysis and is now widely used to segment both 2D and 3D medical images. Deep-learning segmentation frameworks rely not only on the choice of network architecture but…

Computer Vision and Pattern Recognition · Computer Science 2017-09-19 Carole H Sudre , Wenqi Li , Tom Vercauteren , Sébastien Ourselin , M. Jorge Cardoso

Deep neural networks for medical image segmentation are often overconfident, compromising both reliability and clinical utility. In this work, we propose differentiable formulations of marginal L1 Average Calibration Error (mL1-ACE) as an…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Theodore Barfoot , Luis C. Garcia-Peraza-Herrera , Samet Akcay , Ben Glocker , Tom Vercauteren

Neural networks for automated image segmentation are typically trained to achieve maximum accuracy, while less attention has been given to the calibration of their confidence scores. However, well-calibrated confidence scores provide…

Image and Video Processing · Electrical Eng. & Systems 2020-10-28 Axel-Jan Rousseau , Thijs Becker , Jeroen Bertels , Matthew B. Blaschko , Dirk Valkenborg

The development of automatic segmentation techniques for medical imaging tasks requires assessment metrics to fairly judge and rank such approaches on benchmarks. The Dice Similarity Coefficient (DSC) is a popular choice for comparing the…

Image and Video Processing · Electrical Eng. & Systems 2023-02-13 Vatsal Raina , Nataliia Molchanova , Mara Graziani , Andrey Malinin , Henning Muller , Meritxell Bach Cuadra , Mark Gales

The accuracy of deep learning methods for two foundational tasks in medical image analysis -- detection and segmentation -- can suffer from class imbalance. We propose a `switching loss' function that adaptively shifts the emphasis between…

Image and Video Processing · Electrical Eng. & Systems 2020-08-11 Deepak Anand , Gaurav Patel , Yaman Dang , Amit Sethi

Automatic segmentation methods are an important advancement in medical image analysis. Machine learning techniques, and deep neural networks in particular, are the state-of-the-art for most medical image segmentation tasks. Issues with…

Image and Video Processing · Electrical Eng. & Systems 2021-11-25 Michael Yeung , Evis Sala , Carola-Bibiane Schönlieb , Leonardo Rundo

Medical image segmentation is fundamental for computer-aided diagnostics, providing accurate delineation of anatomical structures and pathological regions. While common metrics such as Accuracy, DSC, IoU, and HD primarily quantify spatial…

Image and Video Processing · Electrical Eng. & Systems 2025-06-16 Wenhao Liang , Wei Zhang , Lin Yue , Miao Xu , Olaf Maennel , Weitong Chen

Miscalibration - a mismatch between a model's confidence and its correctness - of Deep Neural Networks (DNNs) makes their predictions hard to rely on. Ideally, we want networks to be accurate, calibrated and confident. We show that, as…

Machine Learning · Computer Science 2020-10-27 Jishnu Mukhoti , Viveka Kulharia , Amartya Sanyal , Stuart Golodetz , Philip H. S. Torr , Puneet K. Dokania

Deep neural networks for medical image segmentation often produce overconfident results misaligned with empirical observations. Such miscalibration, challenges their clinical translation. We propose to use marginal L1 average calibration…

Computer Vision and Pattern Recognition · Computer Science 2025-07-15 Theodore Barfoot , Luis Garcia-Peraza-Herrera , Ben Glocker , Tom Vercauteren

In semantic segmentation, even state-of-the-art deep learning models fall short of the performance required in certain high-stakes applications such as medical image analysis. In these cases, performance can be improved by allowing a model…

Machine Learning · Computer Science 2026-05-26 Bruno Laboissiere Camargos Borges , Bruno Machado Pacheco , Danilo Silva

Dice loss is widely used for medical image segmentation, and many improvement loss functions based on such loss have been proposed. However, further Dice loss improvements are still possible. In this study, we reconsidered the use of Dice…

Image and Video Processing · Electrical Eng. & Systems 2022-07-19 Sota Kato , Kazuhiro Hotta

We propose a generic framework to calibrate accuracy and confidence of a prediction in deep neural networks through stochastic inferences. We interpret stochastic regularization using a Bayesian model, and analyze the relation between…

Machine Learning · Computer Science 2019-04-25 Seonguk Seo , Paul Hongsuck Seo , Bohyung Han

Recent works have shown that deep neural networks can achieve super-human performance in a wide range of image classification tasks in the medical imaging domain. However, these works have primarily focused on classification accuracy,…

Computer Vision and Pattern Recognition · Computer Science 2020-09-10 Gongbo Liang , Yu Zhang , Xiaoqin Wang , Nathan Jacobs

Optimal decision making requires that classifiers produce uncertainty estimates consistent with their empirical accuracy. However, deep neural networks are often under- or over-confident in their predictions. Consequently, methods have been…

We propose two novel loss functions, Multiplicative Loss and Confidence-Adaptive Multiplicative Loss, for semantic segmentation in medical and cellular images. Although Cross Entropy and Dice Loss are widely used, their additive combination…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Yuto Yokoi , Kazuhiro Hotta

Segmentation is a fundamental task in medical image analysis. The clinical interest is often to measure the volume of a structure. To evaluate and compare segmentation methods, the similarity between a segmentation and a predefined ground…

Image and Video Processing · Electrical Eng. & Systems 2020-10-09 Jeroen Bertels , David Robben , Dirk Vandermeulen , Paul Suetens

In many medical imaging and classical computer vision tasks, the Dice score and Jaccard index are used to evaluate the segmentation performance. Despite the existence and great empirical success of metric-sensitive losses, i.e. relaxations…

Image and Video Processing · Electrical Eng. & Systems 2020-10-27 Tom Eelbode , Jeroen Bertels , Maxim Berman , Dirk Vandermeulen , Frederik Maes , Raf Bisschops , Matthew B. Blaschko

Calibration is crucial in deep learning applications, especially in fields like healthcare and autonomous driving, where accurate confidence estimates are vital for decision-making. However, deep neural networks often suffer from…

Machine Learning · Computer Science 2024-10-17 Linwei Tao , Haolan Guo , Minjing Dong , Chang Xu

The Dice score and Jaccard index are commonly used metrics for the evaluation of segmentation tasks in medical imaging. Convolutional neural networks trained for image segmentation tasks are usually optimized for (weighted) cross-entropy.…

Computer Vision and Pattern Recognition · Computer Science 2020-10-09 Jeroen Bertels , Tom Eelbode , Maxim Berman , Dirk Vandermeulen , Frederik Maes , Raf Bisschops , Matthew Blaschko
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