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The diagnosis and prognosis of cancer are typically based on multi-modal clinical data, including histology images and genomic data, due to the complex pathogenesis and high heterogeneity. Despite the advancements in digital pathology and…

Quantitative Methods · Quantitative Biology 2024-04-15 Zeyu Zhang , Yuanshen Zhao , Jingxian Duan , Yaou Liu , Hairong Zheng , Dong Liang , Zhenyu Zhang , Zhi-Cheng Li

Cervical cancer is a crucial global health concern for women, and the persistent infection of High-risk HPV mainly triggers this remains a global health challenge, with young women diagnosis rates soaring from 10\% to 40\% over three…

Image and Video Processing · Electrical Eng. & Systems 2024-08-21 Tatsuhiro Baba , Abu Saleh Musa Miah , Jungpil Shin , Md. Al Mehedi Hasan

Microscopic histology image analysis is a cornerstone in early detection of breast cancer. However these images are very large and manual analysis is error prone and very time consuming. Thus automating this process is in high demand. We…

Computer Vision and Pattern Recognition · Computer Science 2018-10-23 Ismaël Koné , Lahsen Boulmane

Breast cancer is one of the main causes of cancer death worldwide. Early diagnostics significantly increases the chances of correct treatment and survival, but this process is tedious and often leads to a disagreement between pathologists.…

Computer Vision and Pattern Recognition · Computer Science 2018-06-26 Alexander Rakhlin , Alexey Shvets , Vladimir Iglovikov , Alexandr A. Kalinin

The improved diagnostic accuracy of ultrasound breast examinations remains an important goal. In this study, we propose a biophysical feature based machine learning method for breast cancer detection to improve the performance beyond a…

Image and Video Processing · Electrical Eng. & Systems 2022-07-15 Jihye Baek , Avice M. O'Connell , Kevin J. Parker

Skin cancer holds the highest incidence rate among all cancers globally. The importance of early detection cannot be overstated, as late-stage cases can be lethal. Classifying skin lesions, however, presents several challenges due to the…

Machine Learning · Computer Science 2023-06-14 Asim Naveed , Syed S. Naqvi , Tariq M. Khan , Imran Razzak

The annotated medical images are usually expensive to be collected. This paper proposes a deep learning method on small data to classify Common Imaging Signs of Lung diseases (CISL) in computed tomography (CT) images. We explore both the…

Computer Vision and Pattern Recognition · Computer Science 2019-03-04 Guocai He

This work proposes a novel approach beyond supervised learning for effective pathological image analysis, addressing the challenge of limited robust labeled data. Pathological diagnosis of diseases like cancer has conventionally relied on…

Computer Vision and Pattern Recognition · Computer Science 2024-10-23 Joonhyeon Song , Seohwan Yun , Seongho Yoon , Joohyeok Kim , Sangmin Lee

Large-scale pre-training models have promoted the development of histopathology image analysis. However, existing self-supervised methods for histopathology images primarily focus on learning patch features, while there is a notable gap in…

Computer Vision and Pattern Recognition · Computer Science 2024-12-09 Kun Wu , Zhiguo Jiang , Kunming Tang , Jun Shi , Fengying Xie , Wei Wang , Haibo Wu , Yushan Zheng

Automatic pathological pulmonary lobe segmentation(PPLS) enables regional analyses of lung disease, a clinically important capability. Due to often incomplete lobe boundaries, PPLS is difficult even for experts, and most prior art requires…

Computer Vision and Pattern Recognition · Computer Science 2017-08-16 Kevin George , Adam P. Harrison , Dakai Jin , Ziyue Xu , Daniel J. Mollura

Histology images with multi-gigapixel of resolution yield rich information for cancer diagnosis and prognosis. Most of the time, only slide-level label is available because pixel-wise annotation is labour intensive task. In this paper, we…

Computer Vision and Pattern Recognition · Computer Science 2022-09-08 Made Satria Wibawa , Kwok-Wai Lo , Lawrence Young , Nasir Rajpoot

Currently, a central challenge and bottleneck in the deployment and validation of computer-aided diagnosis (CAD) models within the field of medical imaging is data scarcity. For lung cancer, one of the most prevalent types worldwide,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-25 António Cardoso , Pedro Sousa , Tania Pereira , Hélder P. Oliveira

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with lung metastases being the most common site of distant spread and significantly worsening prognosis. Despite the growing availability of clinical and…

Tissues and Organs · Quantitative Biology 2025-01-22 Jeff J. H. Kim , George R. Nahass , Yang Dai , Theja Tulabandhula

Graphical models are commonly used to discover associations within gene or protein networks for complex diseases such as cancer. Most existing methods estimate a single graph for a population, while in many cases, researchers are interested…

Image segmentation is a fundamental problem in medical image analysis. In recent years, deep neural networks achieve impressive performances on many medical image segmentation tasks by supervised learning on large manually annotated data.…

Computer Vision and Pattern Recognition · Computer Science 2018-01-26 Ling Zhang , Vissagan Gopalakrishnan , Le Lu , Ronald M. Summers , Joel Moss , Jianhua Yao

A number of studies on lung nodule classification lack clinical/biological interpretations of the features extracted by convolutional neural network (CNN). The methods like class activation mapping (CAM) and gradient-based CAM (Grad-CAM)…

Computer Vision and Pattern Recognition · Computer Science 2019-12-18 Yiming Lei , Yukun Tian , Hongming Shan , Junping Zhang , Ge Wang , Mannudeep Kalra

Histopathological assessments, including surgical resection and core needle biopsy, are the standard procedures in the diagnosis of the prostate cancer. Current interpretation of the histopathology images includes the determination of the…

Computer Vision and Pattern Recognition · Computer Science 2017-05-12 Naiyun Zhou , Andrey Fedorov , Fiona Fennessy , Ron Kikinis , Yi Gao

Segmentation of lymphoma lesions is challenging due to their varied sizes and locations in whole-body PET scans. This work presents a fully-automated segmentation technique using a multi-center dataset of diffuse large B-cell lymphoma…

We propose a method to incorporate the intensity information of a target lesion on CT scans in training segmentation and detection networks. We first build an intensity-based lesion probability (ILP) function from an intensity histogram of…

Image and Video Processing · Electrical Eng. & Systems 2023-07-13 Seung Yeon Shin , Thomas C. Shen , Ronald M. Summers

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He